# Respiratory system

Respiratory system
A complete, schematic view of the human respiratory system with their parts and functions.
Details
Identifiers
Latin systema respiratorium
TA 06.0.00.000
FMA 7158
Anatomical terminology

The respiratory system (called also respiratory apparatus, ventilatory system) is a biological system consisting of specific organs and structures used for the process of respiration in an organism. The respiratory system is involved in the intake and exchange of oxygen and carbon dioxide between an organism and the environment.

In air-breathing vertebrates like human beings, respiration takes place in the respiratory organs called lungs. The passage of air into the lungs to supply the body with oxygen is known as inhalation, and the passage of air out of the lungs to expel carbon dioxide is known as exhalation; this process is collectively called breathing or ventilation. In humans and other mammals, the anatomical features of the respiratory system include trachea, bronchi, bronchioles, lungs, and diaphragm. Molecules of oxygen and carbon dioxide are passively exchanged, by diffusion, between the gaseous external environment and the blood. This exchange process occurs in the alveoli (air sacs) in the lungs.[1]

In fish and many invertebrates, respiration takes place through the gills. Other animals, such as insects, have respiratory systems with very simple anatomical features, and in amphibians even the skin plays a vital role in gas exchange. Plants also have respiratory systems but the directionality of gas exchange can be opposite to that in animals. The respiratory system in plants also includes anatomical features such as holes on the undersides of leaves known as stomata.[2]

## Comparative anatomy and physiology

### Horses

Horses are obligate nasal breathers which means that they are different from many other mammals because they do not have the option of breathing through their mouths and must take in oxygen through their noses.

### Elephants

The elephant is the only animal known to have no pleural space. Rather, the parietal and visceral pleura are both composed of dense connective tissue and joined to each other via loose connective tissue.[3] This lack of a pleural space, along with an unusually thick diaphragm, are thought to be evolutionary adaptations allowing the elephant to remain underwater for long periods of time while breathing through its trunk which emerges as a snorkel.[4]

### Birds

The respiratory system of birds differs significantly from that found in mammals, containing unique anatomical features such as air sacs. The lungs of birds also do not have the capacity to inflate as birds lack a diaphragm and a pleural cavity. Gas exchange in birds occurs between air capillaries and blood capillaries, rather than in alveoli.

### Reptiles

X-ray video of a female American alligator while breathing.

The anatomical structure of the lungs is less complex in reptiles than in mammals, with reptiles lacking the very extensive airway tree structure found in mammalian lungs. Gas exchange in reptiles still occurs in alveoli however, reptiles do not possess a diaphragm. Thus, breathing occurs via a change in the volume of the body cavity which is controlled by contraction of intercostal muscles in all reptiles except turtles. In turtles, contraction of specific pairs of flank muscles governs inspiration or expiration.[5]

### Amphibians

Both the lungs and the skin serve as respiratory organs in amphibians. The skin of these animals is highly vascularized and moist, with moisture maintained via secretion of mucus from specialized cells. While the lungs are of primary importance to breathing control, the skin's unique properties aid rapid gas exchange when amphibians are submerged in oxygen-rich water.[6]

### Fish

In most fish, respiration takes place through gills. (See also aquatic respiration.) Lungfish, however, do possess one or two lungs. The labyrinth fish have developed a special organ that allows them to take advantage of the oxygen of the air.

## Anatomy in invertebrates

### Arthropods

Some species of crab use a respiratory organ called a branchiostegal lung.[7] Its gill tissue is formed so as to increase the surface area and the lung is more suited to taking oxygen from the air than from water. Some of the smallest spiders and mites can breathe simply by exchanging gas through the surface of the body. Larger spiders, scorpions and other arthropods use a primitive book lung.

#### Insects

Most insects breath passively through their spiracles (special openings in the exoskeleton) and the air reaches the body by means of a series of smaller and smaller pipes called 'trachaea' when their diameter is relatively large and 'tracheoles' when their diameter is very small. Diffusion of gases is effective over small distances but not over larger ones, this is one of the reasons insects are all relatively small. Insects which do not have spiracles and trachaea, such as some Collembola, breathe directly through their skins, also by diffusion of gases.[8] The number of spiracles an insect has is variable between species, however they always come in pairs, one on each side of the body, and usually one per segment. Some of the Diplura have eleven, with four pairs on the thorax, but in most of the ancient forms of insects, such as Dragonflies and Grasshoppers there are two thoracic and eight abdominal spiracles. However, in most of the remaining insects there are less. It is at this level of the tracheoles that oxygen is delivered to the cells for respiration. The trachea are water-filled due to the permeable membrane of the surrounding tissues. During exercise, the water level retracts due to the increase in concentration of lactic acid in the muscle cells. This lowers the water potential and the water is drawn back into the cells via osmosis and air is brought closer to the muscle cells. The diffusion pathway is then reduced and gases can be transferred more easily.

Insects were once believed to exchange gases with the environment continuously by the simple diffusion of gases into the tracheal system. More recently, however, large variation in insect ventilatory patterns have been documented and insect respiration appears to be highly variable. Some small insects do demonstrate continuous respiration and may lack muscular control of the spiracles. Others, however, utilize muscular contraction of the abdomen along with coordinated spiracle contraction and relaxation to generate cyclical gas exchange patterns and to reduce water loss into the atmosphere. The most extreme form of these patterns is termed discontinuous gas exchange cycles (DGC).[9]

### Molluscs

Molluscs generally possess gills that allow exchange of oxygen from an aqueous environment into the circulatory system. These animals also possess a heart that pumps blood which contains hemocyaninine as its oxygen-capturing molecule. Hence, this respiratory system is similar to that of vertebrate fish. The respiratory system of gastropods can include either gills or a lung.

## Physiology in mammals

### Ventilation

In respiratory physiology, the ventilation rate is the rate at which gas enters or leaves the lung. It is categorized under the following definitions:

Measurement Equation Description
Minute ventilation tidal volume * respiratory rate[1][2] the total volume of gas entering the lungs per minute.
Alveolar ventilation (tidal volume – dead space) * respiratory rate [1] the volume of gas per unit time that reaches the alveoli, the respiratory portions of the lungs where gas exchange occurs.
Dead space ventilation dead space * respiratory rate[3] the volume of gas per unit time that does not reach these respiratory portions, but instead remains in the airways (trachea, bronchi, etc.).

#### Control

Ventilation occurs via the respiratory center in the medulla oblongata and the pons of the brainstem. These areas of the brain form a series of interconnected brain cells within the lower and middle brain stem which receive information about the arterial partial pressure of oxygen (${\displaystyle P_{{\mathrm {O} }_{2}}}$) and the arterial partial pressure of carbon dioxide (${\displaystyle P_{{\mathrm {CO} }_{2}}}$). This information determines the average medium term rate of ventilation of the alveoli of the lungs, to keep the arterial ${\displaystyle P_{{\mathrm {O} }_{2}}}$ and ${\displaystyle P_{{\mathrm {CO} }_{2}}}$ constant. The respiratory center does so via motor neurons which activate the skeletal muscles of respiration (in particular the diaphragm). Sections through the medulla oblongata and pons suggest that the respiratory center consists of a pneumotaxic center, an apneustic center, and a dorsal and ventral respiratory groups . This latter group is especially sensitive during infancy, and the neurons can be destroyed if the infant is dropped and/or shaken violently. The result can be death due to "shaken baby syndrome".[10]

The breathing rate increases when the ${\displaystyle P_{{\mathrm {CO} }_{2}}}$ in the blood increases. This is detected by peripheral chemoreceptors in the aorta and carotid artery and central chemoreceptors in the medulla. Exercise also increases the respiratory rate, due to the action of proprioceptors, an increase in body temperature, the release of epinephrine from the adrenal glands, and from motor impulses originating from the brain.[11] Information received from stretch receptors in the lungs limits tidal volume (i.e. the depth of inhalation and exhalation).

#### Inhalation

Inhalation is initiated by the diaphragm and supported by the external intercostal muscles. Normal resting respirations are 10 to 18 breaths per minute, with a time period of 2 seconds. During vigorous inhalation (at rates exceeding 35 breaths per minute), or in approaching respiratory failure, accessory muscles of respiration are recruited for support. These consist of sternocleidomastoid, platysma, and the scalene muscles of the neck. Pectoral muscles and latissimus dorsi are also accessory muscles.

Under normal conditions, the diaphragm is the primary driver of inhalation. When the diaphragm contracts, the ribcage expands and the contents of the abdomen are moved downward. This results in a larger thoracic volume and negative pressure (with respect to atmospheric pressure) inside the thorax. As the pressure in the chest falls, air moves into the conducting zone. Here, the air is filtered, warmed, and humidified as it flows to the lungs.

During forced inhalation, as when taking a deep breath, the external intercostal muscles and accessory muscles aid in further expanding the thoracic cavity. During inhalation the diaphragm contracts.

#### Exhalation

Exhalation is generally a passive process; however, active or forced exhalation is achieved by the abdominal and the internal intercostal muscles. During this process air is forced or exhaled out.

The lungs have a natural elasticity: as they recoil from the stretch of inhalation, air flows back out until the pressures in the chest and the atmosphere reach equilibrium.[12]

During forced exhalation, as when blowing out a candle, expiratory muscles including the abdominal muscles and internal intercostal muscles, generate abdominal and thoracic pressure, which forces air out of the lungs.

### Gas exchange

The major function of the respiratory system is the equilibration of the blood gases with those in the alveolar air. The lungs of an average person at rest, and breathing normally contain between about 2.5 and 3 liters of air. This semi-stagnant volume of air[nb 1] that always remains in the lung alveoli after a normal exhalation is termed the functional residual capacity.[13] With each breath only about 350 ml (i.e. less than 15%) of this alveolar air is expelled into the ambient air to be replaced with the same volume of fresh, but moistened, atmospheric air. It is therefore obvious that the composition of the alveolar air (or functional residual capacity) changes very little under normal circumstances: the alveolar partial pressure of oxygen (${\displaystyle P_{{\mathrm {O} }_{2}}}$) remains very close to 105 mmHg (14 kPa), and that of carbon dioxide (${\displaystyle P_{{\mathrm {CO} }_{2}}}$) varies minimally from 40 mmHg (5.3 kPa) throughout the respiratory cycle (of inhalation and exhalation).[13] The corresponding partial pressures of oxygen and carbon dioxide in the ambient (dry) air at sea level are 160 mmHg (21 kPa) and 0.3 mmHg (0.04 kPa) respectively.[13]

This marked difference between the composition of the alveolar air and that of the ambient air can be maintained because the functional residual capacity is contained in a dead-end sac connected to the outside air by a fairly narrow and relatively long tube (the airways: nose, pharynx, larynx, trachea, bronchi and their branches down to the bronchioles). This anatomy and the fact that the lungs are not emptied and re-inflated with each breath, provides the animal with a very special portable atmosphere, whose composition differs significantly from the present-day ambient air.[14] It is this portable atmosphere (the functional residual capacity) to which the blood and therefore the body tissues are exposed - not to the outside air.

All the blood returning from the body tissues to the right side of the heart flows through the pulmonary capillaries before being pumped around the body again. On its passage through the lungs the blood comes into close contact with the alveolar air, separated from it by a very thin diffusion membrane which is only about 0.5 μm thick.[13] The gas pressures in the blood will therefore rapidly equilibrate with those in the alveoli, ensuring that the arterial blood that circulates to all the tissues throughout the body has an oxygen tension of 105 mmHg (14 kPa), and a carbon dioxide tension of 40 mmHg (5.3 kPa). These arterial partial pressures of oxygen and carbon dioxide are homeostatically controlled. A rise in the arterial ${\displaystyle P_{{\mathrm {CO} }_{2}}}$, and, to a lesser extent, a fall in the arterial ${\displaystyle P_{{\mathrm {O} }_{2}}}$, will reflexly cause deeper and faster breathing till the blood gas tension return to normal. The converse happens when the carbon dioxide tension falls, or, again to a lesser extent, the oxygen tension rises: the rate and depth of breathing are reduced till blood gas normality is restored.

Since the blood arriving in the pulmonary capillaries has a ${\displaystyle P_{{\mathrm {O} }_{2}}}$ of, on average, 45 mmHg (6 kPa), while the pressure in the alveolar air is 105 mmHg, there will be a net diffusion of oxygen into the capillary blood, changing the composition of the 3 liters of alveolar air slightly. Similarly, since the blood arriving in the pulmonary capillaries has a ${\displaystyle P_{{\mathrm {CO} }_{2}}}$ of also about 45 mmHg, whereas that of the alveolar air is 40 mmHg (5.3 kPa), there is a net movement of carbon dioxide out of the capillaries into the alveoli. The changes brought about by these flows of individual gases into and out of the functional residual capacity necessitate the replacement of about 15% of the alveolar air with ambient air every 5 seconds or so. This is very tightly controlled not only by the monitoring of the arterial blood gases (which accurately reflect composition of the alveolar air) by the aortic and carotid bodies, but also by oxygen and carbon dioxide sensors in the lungs, though the latter primarily determine the diameters of the bronchioles and pulmonary capillaries, and are therefore responsible for directing the flow of air and blood to different parts of the lungs.

It is only as a result of maintaining the composition of the 3 liters alveolar air that with each breath some carbon dioxide is discharged into the atmosphere and some oxygen is taken up from the outside air. If more carbon dioxide than usual has been lost by a short period of hyperventilation, respiration will be slowed down or halted until the alveolar ${\displaystyle P_{{\mathrm {CO} }_{2}}}$ has returned to 40 mmHg (5.3 kPa). It is therefore strictly speaking untrue that the primary function of the respiratory system is to rid the body of carbon dioxide “waste”. The carbon dioxide that is breathed out with each breath could probably be more correctly be seen as a byproduct of the body’s extracellular fluid carbon dioxide and pH homeostats

If these homeostats are compromised, then a respiratory acidosis, or a respiratory alkalosis will occur. In the long run these can be compensated by renal adjustments to the H+ and HCO3- concentrations in the plasma; but since this takes time, the hyperventilation syndrome can, for instance, occur when agitation or anxiety cause a person to breathe fast and deeply thus causing a distressing respiratory alkalosis through the blowing off of too much CO2 from the blood into the outside air.

### Immune functions

Airway epithelial cells can secrete a variety of molecules that aid in the defense of lungs. Secretory immunoglobulins (IgA), collectins (including Surfactant A and D), defensins and other peptides and proteases, reactive oxygen species, and reactive nitrogen species are all generated by airway epithelial cells. These secretions can act directly as antimicrobials to help keep the airway free of infection. Airway epithelial cells also secrete a variety of chemokines and cytokines that recruit the traditional immune cells and others to site of infections.

Most of the respiratory system is lined with mucous membranes that contain mucosal-associated lymphoid tissue, which produces white blood cells such as lymphocytes.

### Metabolic and endocrine functions of the lungs

In addition to their functions in gas exchange, the lungs have a number of metabolic functions. They manufacture surfactant for local use, as noted above. They also contain a fibrinolytic system that lyses clots in the pulmonary vessels. They release a variety of substances that enter the systemic arterial blood and they remove other substances from the systemic venous blood that reach them via the pulmonary artery. Prostaglandins are removed from the circulation, but they are also synthesized in the lungs and released into the blood when lung tissue is stretched. The lungs also activate one hormone; the physiologically inactive decapeptide angiotensin I is converted to the pressor, aldosterone-stimulating octapeptide angiotensin II in the pulmonary circulation. The reaction occurs in other tissues as well, but it is particularly prominent in the lungs. Large amounts of the angiotensin-converting enzyme responsible for this activation are located on the surface of the endothelial cells of the pulmonary capillaries. The converting enzyme also inactivates bradykinin. Circulation time through the pulmonary capillaries is less than one second, yet 70% of the angiotensin I reaching the lungs is converted to angiotensin II in a single trip through the capillaries. Four other peptidases have been identified on the surface of the pulmonary endothelial cells.

#### Vocalization

The movement of gas through the larynx, pharynx and mouth allows humans to speak, or phonate. Vocalization, or singing, in birds occurs via the syrinx, an organ located at the base of the trachea. The vibration of air flowing across the larynx (vocal cords), in humans, and the syrinx, in birds, results in sound. Because of this, gas movement is extremely vital for communication purposes.

#### Temperature control

Panting in dogs, cats and some other animals provides a means of controlling body temperature. This physiological response is used as a cooling mechanism.

#### Coughing and sneezing

Irritation of nerves within the nasal passages or airways, can induce a cough reflex and sneezing. These responses cause air to be expelled forcefully from the trachea or nose, respectively. In this manner, irritants caught in the mucus which lines the respiratory tract are expelled or moved to the mouth where they can be swallowed. During coughing, contraction of the smooth muscle narrows the trachea by pulling the ends of the cartilage plates together and by pushing soft tissue out into the lumen. This increases the expired airflow rate to dislodge and remove any irritant particle or mucus.

## Development

### Humans and mammals

The respiratory system lies dormant in the human fetus during pregnancy. At birth, the respiratory system becomes fully functional upon exposure to air, although some lung development and growth continues throughout childhood.[15] Pre-term birth can lead to infants with under-developed lungs. These lungs show incomplete development of the alveolar type II cells, cells that produce surfactant. The lungs of pre-term infants may not function well because the lack of surfactant leads to increased surface tension within the alveoli. Thus, many alveoli collapse such that no gas exchange can occur within some or most regions of an infant's lungs, a condition termed respiratory distress syndrome. Basic scientific experiments, carried out using cells from chicken lungs, support the potential for using steroids as a means of furthering development of type II alveolar cells.[16] In fact, once a pre-mature birth is threatened, every effort is made to delay the birth, and a series of steroid shots is frequently administered to the mother during this delay in an effort to promote lung growth.[17]

## Disease

Disorders of the respiratory system can be classified into four general areas:

Coughing is of major importance, as it is the body's main method to remove dust, mucus, saliva, and other debris from the lungs. Inability to cough can lead to infection. Deep breathing exercises may help keep finer structures of the lungs clear from particulate matter, etc.

The respiratory tract is constantly exposed to microbes due to the extensive surface area, which is why the respiratory system includes many mechanisms to defend itself and prevent pathogens from entering the body.

Disorders of the respiratory system are usually treated internally by a pulmonologist and Respiratory Therapist.

## Plants

Plants use carbon dioxide gas in the process of photosynthesis, and exhale oxygen gas as waste. The chemical equation of photosynthesis is 6 CO2 (carbon dioxide) and 6 H2O (water) and that makes 6 O2 (oxygen) and C6H12O6 (glucose). What is not expressed in the chemical equation is the capture of energy from sunlight which occurs. Photosynthesis uses electrons on the carbon atoms as the repository for that energy. Respiration is the opposite of photosynthesis. It reclaims the energy to power chemical reactions in cells. In so doing the carbon atoms and their electrons are combined with oxygen forming a gas which is easily removed from both the cells and the organism. Plants use both processes, photosynthesis to capture the energy and respiration to use it.

Plant respiration is limited by the process of diffusion. Plants take in carbon dioxide through holes on the undersides of their leaves known as stoma or pores. However, most plants require little air.[citation needed] Most plants have relatively few living cells outside of their surface because air (which is required for metabolic content) can penetrate only skin deep. However, most plants are not involved in highly aerobic activities, and thus have no need of these living cells.

## Foot note

1. ^ Although the functional residual capacity is described here as a “semi-stagnant” volume of air, this is only true in the sense that a lake of water with a small inlet and outlet seems “stagnant” compared with the rest of river. In the case of the “functional residual capacity” the entire volume of trapped air (or the “lake” in the river analogy) is always thoroughly mixed with the incoming inhaled air. This is brought about by the microscopic subdivisions of the “functional residual capacity” into many billions of smaller, minute air sacs, the alveoli, into which the inhaled air enters turbulently. Under normal circumstances the “functional residual capacity” is far from “stagnant” but always represents a thoroughly stirred large volume of the stored air with a small amount of diluted (with water vapor) fresh inhaled air, after each in-breath.

## References

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2. ^ West, John B. Respiratory physiology-- the essentials. Baltimore: Williams & Wilkins. pp. 1–10. ISBN 0-683-08937-4.
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5. ^ Respiratory system. Encyclopædia Britannica.
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7. ^ J. Halperin, M. Ansaldo, G. N. Pellerano & C. M. Luquet (2000). "Bimodal breathing in the estuarine crab Chasmagnathus granulatus Dana 1851 — physiological and morphological studies". Comparative Biochemistry and Physiology - Part A: Molecular & Integrative Physiology 126 (3): 341–349. doi:10.1016/S1095-6433(00)00216-6. PMID 10964029.
8. ^ The Earth Life Web, Insect Morphology and Anatomy. Earthlife.net. Retrieved on 2013-04-21.
9. ^ Lighton, JRB (January 1996). "Discontinuous gas exchange in insects". Annu Rev Entomology 41: 309–324. doi:10.1146/annurev.en.41.010196.001521.
10. ^ The combination of a crying baby and a frustrated parent or caregiver CAN BE DEADLY. Saskatchewan Prevention Institute. usask.ca.
11. ^ "Respiration". Harvey Project. Retrieved 27 July 2012.
12. ^ A simple model of how the lungs are inflated can be built from a bell jar
13. ^ a b c d Tortora, Gerard J.; Anagnostakos, Nicholas P. (1987). Principles of anatomy and physiology (Fifth ed.). New York: Harper & Row, Publishers. pp. 570–572. ISBN 0-06-350729-3.
14. ^ Lovelock, James (1991). Healing Gaia: Practical medicine for the Planet. New York: Harmony Books. pp. 21–34, 73–88. ISBN 0-517-57848-4.
15. ^ Michelle, Julia (March 7, 2011). "How Do Babies Breathe in the Womb?".
16. ^ Sullivan, LC; Orgeig, S (2001). "Dexamethasone and epinephrine stimulate surfactant secretion in type II cells of embryonic chickens". American Journal of Physiology. Regulatory, Integrative and Comparative Physiology 281 (3): R770–7. PMID 11506991.
17. ^ Premature Babies, Lung Development & Respiratory Distress Syndrome. Pregnancy-facts.com.