Talk:Oncovirus

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DNA viruses

• Human papilloma virus (HPV), a DNA virus, causes transformation in cells through interfering with tumor suppressor proteins such as p53. Interfering with the action of p53 allows a cell infected with the virus to move into a different stage of the cell cycle allowing the virus genome to be replicated forcing the cell into the S phase of the cell cycle could cause the cell to become transformed.[2] It increases risk of, e.g., cervical cancer.

   * Human herpes virus 8 is associated with Kaposi’s sarcoma, a type of skin cancer.[3]
   * Epstein-Barr virus (EBV) is associated with four types of cancers
   * Merkel cell polyomavirus - a polyoma virus - is strongly associated with the development of Merkel cell cancer - a rare form of skin cancer.[4]

[edit] RNA viruses

It is not only DNA viruses that are associated with cancers some RNA viruses have also been associated such as the Hepatitis C Virus as well as Human T cell leukaemia virus-1 (HTLV-1)

[edit] Overview table Virus Associated cancer types Hepatitis viruses, including hepatitis B and hepatitis C Hepatocellular carcinoma (liver cancer).[5][6] Human T-lymphotropic virus Tropical spastic paraparesis and adult T-cell leukemia[7] Human papillomaviruses Cancers of cervix, skin, anus and penis.[8] mouth, throat and maybe lung cancer. Kaposi’s sarcoma-associated herpesvirus Kaposi’s sarcoma and Body cavity lymphoma Epstein–Barr virus Burkitt’s lymphoma, Hodgkin’s lymphoma, B lymphoproliferative disease and Nasopharyngeal carcinoma.[9] The first person to offer a viral theory of cancer origin was Russian scientist Lev Zilber. He did it at the time when the idea that cancer can be caused by viruses seemed ridiculous. The conditions under which he worked were marginal for survival. His contribution should be appreciated. http://www.sciencedirect.com/science?_ob=ArticleURL&_udi=B7CT1-4S0GJV5-5&_user=495826&_coverDate=12%2F31%2F1992&_rdoc=1&_fmt=high&_orig=gateway&_origin=gateway&_sort=d&_docanchor=&view=c&_searchStrId=1725640155&_rerunOrigin=google&_acct=C000024158&_version=1&_urlVersion=0&_userid=495826&md5=0a2e4044ebfd1540646fa3a8020e51b7&searchtype=a —Preceding unsigned comment added by 151.141.84.80 (talk) 21:08, 20 April 2011 (UTC)

Hepatitis A is not a oncovirus

Source: Hepatitis A infection and primary hepatocellular carcinoma. http://www.ncbi.nlm.nih.gov/pubmed/224967