Sink condition: Difference between revisions
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Sink condition means maintaining a volume of dissolution media |
Sink condition means maintaining a volume of [[dissolution media|solvent]] that is 5 to 10 times greater than the volume at the [[saturation point]] of the drug contained in the [[dosage form]] being tested.<ref name="Shear Rate & Sink Conditions LabHut">{{cite web|title=Shear Rate & Sink Conditions|url=http://www.labhut.com/education-centre/about-dissolution-testing/shear-rate-sink-conditions.html|website=LabHut|publisher=SMI-LabHut Ltd|accessdate=17 April 2016}}</ref> |
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During the [[dissolution testing]] of a chemical or [[drug]], "sink condition" must be maintained, otherwise when the concentration begins to get closer to the saturation point, the [[dissolution rate]] will decrease gradually, corrupting the test result, although the [[total soluble amount|solubility]] will remain unaffected.<ref name="Liu2008">{{cite book|author=Ron Liu|title=Water-Insoluble Drug Formulation, Second Edition|url=http://books.google.com/books?id=4cfzT2ZY8hUC&pg=PA73|date=18 January 2008|publisher=CRC Press|isbn=978-1-4200-0955-2|pages=73–4}}</ref><ref name="GhoshJasti2004">{{cite book|author1=Tapash K. Ghosh|author2=Bhaskara R. Jasti|title=Theory and Practice of Contemporary Pharmaceutics|url=http://books.google.com/books?id=whiC7aSFLY8C&pg=PA203|date=23 November 2004|publisher=CRC Press|isbn=978-0-203-64447-8|pages=203–4}}</ref><ref>{{cite book|title=Remington Essentials of Pharmaceutics - Felton, Linda 2012: Remington Essentials of Pharmaceutics - Felton, Linda 2012|url=http://books.google.com/books?id=xYvrAwAAQBAJ&pg=PA65|publisher=booksonline|pages=65–66|id=GGKEY:KQQLT3XT7H1}}</ref> |
During the [[dissolution testing]] of a chemical or [[drug]], "sink condition" must be maintained, otherwise when the concentration begins to get closer to the saturation point, the [[dissolution rate]] will decrease gradually, corrupting the test result, although the [[total soluble amount|solubility]] will remain unaffected.<ref name="Liu2008">{{cite book|author=Ron Liu|title=Water-Insoluble Drug Formulation, Second Edition|url=http://books.google.com/books?id=4cfzT2ZY8hUC&pg=PA73|date=18 January 2008|publisher=CRC Press|isbn=978-1-4200-0955-2|pages=73–4}}</ref><ref name="GhoshJasti2004">{{cite book|author1=Tapash K. Ghosh|author2=Bhaskara R. Jasti|title=Theory and Practice of Contemporary Pharmaceutics|url=http://books.google.com/books?id=whiC7aSFLY8C&pg=PA203|date=23 November 2004|publisher=CRC Press|isbn=978-0-203-64447-8|pages=203–4}}</ref><ref>{{cite book|title=Remington Essentials of Pharmaceutics - Felton, Linda 2012: Remington Essentials of Pharmaceutics - Felton, Linda 2012|url=http://books.google.com/books?id=xYvrAwAAQBAJ&pg=PA65|publisher=booksonline|pages=65–66|id=GGKEY:KQQLT3XT7H1}}</ref> |
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Revision as of 09:10, 18 April 2016
Sink condition means maintaining a volume of solvent that is 5 to 10 times greater than the volume at the saturation point of the drug contained in the dosage form being tested.[1]
During the dissolution testing of a chemical or drug, "sink condition" must be maintained, otherwise when the concentration begins to get closer to the saturation point, the dissolution rate will decrease gradually, corrupting the test result, although the solubility will remain unaffected.[2][3][4]
See also
References
- ^ "Shear Rate & Sink Conditions". LabHut. SMI-LabHut Ltd. Retrieved 17 April 2016.
- ^ Ron Liu (18 January 2008). Water-Insoluble Drug Formulation, Second Edition. CRC Press. pp. 73–4. ISBN 978-1-4200-0955-2.
- ^ Tapash K. Ghosh; Bhaskara R. Jasti (23 November 2004). Theory and Practice of Contemporary Pharmaceutics. CRC Press. pp. 203–4. ISBN 978-0-203-64447-8.
- ^ Remington Essentials of Pharmaceutics - Felton, Linda 2012: Remington Essentials of Pharmaceutics - Felton, Linda 2012. booksonline. pp. 65–66. GGKEY:KQQLT3XT7H1.
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