Central chromatolysis: Difference between revisions
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[[Image:Central chromatolysis - intermed mag - cropped.jpg|thumb|right|[[Micrograph]] of the [[anterior horn of spinal cord|anterior horn of the spinal cord]] showing [[motor neuron]]s with central chromatolysis. [[H&E stain]].]] |
[[Image:Central chromatolysis - intermed mag - cropped.jpg|thumb|right|[[Micrograph]] of the [[anterior horn of spinal cord|anterior horn of the spinal cord]] showing [[motor neuron]]s with central chromatolysis. [[H&E stain]].]] |
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[[Image:Central chromatolysis - nf - very high mag.jpg|thumb|right|[[Micrograph]] of the [[anterior horn of spinal cord|anterior horn of the spinal cord]] showing [[motor neuron]]s with central chromatolysis. [[w:Neurofilament|Neurofilament]] [[w:immunostain|immunostain]].]] |
[[Image:Central chromatolysis - nf - very high mag.jpg|thumb|right|[[Micrograph]] of the [[anterior horn of spinal cord|anterior horn of the spinal cord]] showing [[motor neuron]]s with central chromatolysis. [[w:Neurofilament|Neurofilament]] [[w:immunostain|immunostain]].]] |
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'''Central chromatolysis''' is a [[histopathology|histopathologic]] change seen in the cell body of a [[neuron]], where the [[chromatin]] and [[cell nucleus]] are pushed to the cell periphery, in response to [[axon]]al injury.<ref>Neuropathology - Basic Reactions. University of Vermont. URL: [http://www.uvm.edu/~jkessler/NP/neuropbr.htm http://www.uvm.edu/~jkessler/NP/neuropbr.htm]. Accessed on: 1 January 2011.</ref><ref name=pmid8909880>{{cite journal |author=Holland GR |title=Experimental trigeminal nerve injury |journal=Crit. Rev. Oral Biol. Med. |volume=7 |issue=3 |pages=237–58 |year=1996 |pmid=8909880 |doi= |url=}}</ref> |
'''Central chromatolysis''' is a [[histopathology|histopathologic]] change seen in the cell body of a [[neuron]], where the [[chromatin]] and [[cell nucleus]] are pushed to the cell periphery, in response to [[axon]]al injury.<ref>Neuropathology - Basic Reactions. University of Vermont. URL: [http://www.uvm.edu/~jkessler/NP/neuropbr.htm http://www.uvm.edu/~jkessler/NP/neuropbr.htm] {{wayback|url=http://www.uvm.edu/~jkessler/NP/neuropbr.htm |date=20100101150924 }}. Accessed on: 1 January 2011.</ref><ref name=pmid8909880>{{cite journal |author=Holland GR |title=Experimental trigeminal nerve injury |journal=Crit. Rev. Oral Biol. Med. |volume=7 |issue=3 |pages=237–58 |year=1996 |pmid=8909880 |doi= |url=}}</ref> |
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This response is associated with increased protein synthesis to accommodate for axonal sprouting. |
This response is associated with increased protein synthesis to accommodate for axonal sprouting. |
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In addition to traumatic injuries, central chromatolysis may be caused by [[vitamin deficiency]] ([[pellagra]]<ref name=pmid15577526>{{cite journal |vauthors=Piercecchi-Marti MD, Pélissier-Alicot AL, Leonetti G, Tervé JP, Cianfarani F, Pellissier JF |title=Pellagra: a rare disease observed in a victim of mental and physical abuse |journal=Am J Forensic Med Pathol |volume=25 |issue=4 |pages=342–4 |date=December 2004 |pmid=15577526 |doi= 10.1097/01.paf.0000136589.28903.e5|url=}}</ref>). |
In addition to traumatic injuries, central chromatolysis may be caused by [[vitamin deficiency]] ([[pellagra]]<ref name=pmid15577526>{{cite journal |vauthors=Piercecchi-Marti MD, Pélissier-Alicot AL, Leonetti G, Tervé JP, Cianfarani F, Pellissier JF |title=Pellagra: a rare disease observed in a victim of mental and physical abuse |journal=Am J Forensic Med Pathol |volume=25 |issue=4 |pages=342–4 |date=December 2004 |pmid=15577526 |doi= 10.1097/01.paf.0000136589.28903.e5|url=}}</ref>). |
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Revision as of 11:01, 18 November 2016
Central chromatolysis is a histopathologic change seen in the cell body of a neuron, where the chromatin and cell nucleus are pushed to the cell periphery, in response to axonal injury.[1][2] This response is associated with increased protein synthesis to accommodate for axonal sprouting. In addition to traumatic injuries, central chromatolysis may be caused by vitamin deficiency (pellagra[3]).
See also
References
- ^ Neuropathology - Basic Reactions. University of Vermont. URL: http://www.uvm.edu/~jkessler/NP/neuropbr.htm Template:Wayback. Accessed on: 1 January 2011.
- ^ Holland GR (1996). "Experimental trigeminal nerve injury". Crit. Rev. Oral Biol. Med. 7 (3): 237–58. PMID 8909880.
- ^ Piercecchi-Marti MD, Pélissier-Alicot AL, Leonetti G, Tervé JP, Cianfarani F, Pellissier JF (December 2004). "Pellagra: a rare disease observed in a victim of mental and physical abuse". Am J Forensic Med Pathol. 25 (4): 342–4. doi:10.1097/01.paf.0000136589.28903.e5. PMID 15577526.