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[[Image:Jonathan Rothberg.jpg|thumb|Rothberg, January 2008]]
[[Image:Jonathan Rothberg.jpg|thumb|Rothberg, January 2008]]
Jonathan M. Rothberg (born 1963) is an American scientist and entrepreneur. He is the founder of CuraGen<ref>{{Cite news|url=https://www.nytimes.com/2011/01/05/health/05gene.html|title=Rothberg Seeks to Make DNA Sequencing Common|last=Pollack|first=Andrew|access-date=2018-06-27|language=en}}</ref>, [[454 Life Sciences]], RainDance Technologies<ref>{{Cite web|url=https://www.weforum.org/about/list-of-technology-pioneers-2008|title=List of Technology Pioneers 2008|website=World Economic Forum|access-date=2018-06-27}}</ref>, [[Ion semiconductor sequencing|Ion Torrent Systems]],<ref name=":1">{{cite news|url=https://www.nytimes.com/2011/01/05/health/05gene.html|title=Taking DNA Sequencing to the Masses|last1=Pollack|first1=Andrew|date=2011|work=The New York Times|accessdate=May 20, 2018|publisher=The New York Times}}</ref> Butterfly Network,<ref name="lurye2018">{{Cite news|url=http://www.courant.com/business/hc-biz-guilford-butterfly-network-rothberg-20180412-story.html|title=Starting With Ultrasound, An Innovation Empire Is Growing In Guilford|last=Lurye|first=Rebecca|work=courant.com|access-date=2018-05-22|language=en-US}}</ref> and the medical device incubator 4Catalyzer.<ref name="hoffman2015">{{Cite news|url=https://www.nhregister.com/connecticut/article/Guilford-incubator-4Catalyzer-aims-for-11361050.php|title=Guilford incubator 4Catalyzer aims for game-changing medical products|last=Hoffman|first=Christopher|date=2015-02-01|work=New Haven Register|access-date=2018-06-05}}</ref> Rothberg is best known for his contributions to next-generation DNA sequencing. He was awarded the [[National Medal of Technology and Innovation]] by President [[Barack Obama]] in 2015 for his “pioneering inventions and commercialization of next-generation DNA sequencing technologies, making access to genomic information easier, faster and more cost-effective for researchers around the world."<ref>{{Cite web|url=https://www.nationalmedals.org/laureates/jonathan-marc-rothberg|title=NMTI Laureate|last=Rothberg|first=|date=|website=|archive-url=|archive-date=|dead-url=|access-date=}}</ref>
Jonathan M. Rothberg (born 1963) is an American scientist and entrepreneur. He is the founder of CuraGen<ref name="NYT2011" />, [[454 Life Sciences]], RainDance Technologies<ref>{{Cite web|url=https://www.weforum.org/about/list-of-technology-pioneers-2008|title=List of Technology Pioneers 2008|website=World Economic Forum|access-date=2018-06-27}}</ref>, [[Ion semiconductor sequencing|Ion Torrent Systems]],<ref name=":1">{{cite news|url=https://www.nytimes.com/2011/01/05/health/05gene.html|title=Taking DNA Sequencing to the Masses|last1=Pollack|first1=Andrew|date=2011|work=The New York Times|accessdate=May 20, 2018|publisher=The New York Times}}</ref> Butterfly Network,<ref name="lurye2018">{{Cite news|url=http://www.courant.com/business/hc-biz-guilford-butterfly-network-rothberg-20180412-story.html|title=Starting With Ultrasound, An Innovation Empire Is Growing In Guilford|last=Lurye|first=Rebecca|work=courant.com|access-date=2018-05-22|language=en-US}}</ref> and the medical device incubator 4Catalyzer.<ref name="hoffman2015">{{Cite news|url=https://www.nhregister.com/connecticut/article/Guilford-incubator-4Catalyzer-aims-for-11361050.php|title=Guilford incubator 4Catalyzer aims for game-changing medical products|last=Hoffman|first=Christopher|date=2015-02-01|work=New Haven Register|access-date=2018-06-05}}</ref> Rothberg is best known for his contributions to next-generation DNA sequencing. He was awarded the [[National Medal of Technology and Innovation]] by President [[Barack Obama]] in 2015 for his “pioneering inventions and commercialization of next-generation DNA sequencing technologies, making access to genomic information easier, faster and more cost-effective for researchers around the world."<ref>{{Cite web|url=https://www.nationalmedals.org/laureates/jonathan-marc-rothberg|title=NMTI Laureate|last=Rothberg|first=|date=|website=|archive-url=|archive-date=|dead-url=|access-date=}}</ref>


==Early Life and Education==
==Early Life and Education==
Rothberg was born in New Haven, CT<ref>{{Cite web|url=https://www.cmu.edu/cmtoday/issues/january-2012-issue/feature-stories/he-did-it/index.html|title=He Did It {{!}} Carnegie Mellon Today|last=Bails|first=Jennifer|date=2012|website=www.cmu.edu|language=en|archive-url=|archive-date=2012-01-02|dead-url=|access-date=2018-06-20}}</ref> to Lillian Rothberg and Henry Rothberg, a chemical engineer who invented a new way of laying ceramic tile and founded Laticrete International, Inc., to commercialize it.<ref name="NYT2011">{{Cite news|url=http://www.nytimes.com/2011/01/05/health/05gene.html|title=Rothberg Seeks to Make DNA Sequencing Common|last=Pollack|first=Andrew|access-date=2018-05-22|language=en}}</ref> Rothberg earned a [[Bachelor of Science|BS]] in [[Chemical engineering|Chemical Engineering]] with an option in [[Biomedical Engineering]] from [[Carnegie Mellon University]] in 1985<ref name="rothberg_bloomberg_profile">{{Cite web|url=https://www.bloomberg.com/research/stocks/private/person.asp?personId=382502&privcapId=275830634|title=Jonathan M. Rothberg Ph.D.: Executive Profile & Biography - Bloomberg|website=www.bloomberg.com|access-date=2018-05-25}}</ref> and went on to earn a [[Master of Science|MS]], [[Master of Philosophy|M.Phil.]], and [[Doctor of Philosophy|Ph.D.]] in biology at [[Yale University]].<ref name="rothberg_bloomberg_profile" /> His graduate work at Yale focused on sequencing the 9,000-base gene ''[[Slit (gene family)|Slit]]'', a project that took him six years and earned him the John Spangler Nicholas Prize for Outstanding Doctoral Candidate in 1991.<ref>{{Cite journal|last=Rothberg|first=Jonathan Marc|last2=Hartley|first2=David A.|last3=Walther|first3=Zenta|last4=Artavanis-Tsakonas|first4=Spyros|date=1988-12-23|title=slit: An EGF-homologous locus of D. melanogaster involved in the development of the embryonic central nervous system|url=https://www.cell.com/abstract/0092-8674(88)90249-8|journal=Cell|language=English|volume=55|issue=6|pages=1047–1059|doi=10.1016/0092-8674(88)90249-8|issn=0092-8674|via=}}</ref><ref>{{Cite journal|date=1992-09-20|title=Modularity of the slit protein: Characterization of a conserved carboxy-terminal sequence in secreted proteins and a motif implicated in extracellular protein interactions|url=https://www.sciencedirect.com/science/article/pii/002228369290891M|journal=Journal of Molecular Biology|language=en|volume=227|issue=2|pages=367–370|doi=10.1016/0022-2836(92)90891-M|issn=0022-2836}}</ref>
Rothberg was born in New Haven, CT<ref>{{Cite web|url=https://www.cmu.edu/cmtoday/issues/january-2012-issue/feature-stories/he-did-it/index.html|title=He Did It {{!}} Carnegie Mellon Today|last=Bails|first=Jennifer|date=2012|website=www.cmu.edu|language=en|archive-url=|archive-date=2012-01-02|dead-url=|access-date=2018-06-20}}</ref> to Lillian Rothberg and Henry Rothberg, a chemical engineer who invented a new way of laying ceramic tile and founded Laticrete International, Inc., to commercialize it.<ref name="NYT2011">{{Cite news|url=http://www.nytimes.com/2011/01/05/health/05gene.html|title=Rothberg Seeks to Make DNA Sequencing Common|last=Pollack|first=Andrew|date=2011-01-04|work=The New York Times|access-date=2018-05-22|language=en}}</ref> Rothberg earned a [[Bachelor of Science|BS]] in [[Chemical engineering|Chemical Engineering]] with an option in [[Biomedical Engineering]] from [[Carnegie Mellon University]] in 1985<ref name="rothberg_bloomberg_profile">{{Cite web|url=https://www.bloomberg.com/research/stocks/private/person.asp?personId=382502&privcapId=275830634|title=Jonathan M. Rothberg Ph.D.: Executive Profile & Biography - Bloomberg|website=www.bloomberg.com|access-date=2018-05-25}}</ref> and went on to earn a [[Master of Science|MS]], [[Master of Philosophy|M.Phil.]], and [[Doctor of Philosophy|Ph.D.]] in biology at [[Yale University]].<ref name="rothberg_bloomberg_profile" /> His graduate work at Yale focused on sequencing the 9,000-base gene ''[[Slit (gene family)|Slit]]'', a project that took him six years and earned him the John Spangler Nicholas Prize for Outstanding Doctoral Candidate in 1991.<ref>{{Cite journal|last=Rothberg|first=Jonathan Marc|last2=Hartley|first2=David A.|last3=Walther|first3=Zenta|last4=Artavanis-Tsakonas|first4=Spyros|date=1988-12-23|title=slit: An EGF-homologous locus of D. melanogaster involved in the development of the embryonic central nervous system|url=https://www.cell.com/abstract/0092-8674(88)90249-8|journal=Cell|language=English|volume=55|issue=6|pages=1047–1059|doi=10.1016/0092-8674(88)90249-8|issn=0092-8674|via=}}</ref><ref>{{Cite journal|date=1992-09-20|title=Modularity of the slit protein: Characterization of a conserved carboxy-terminal sequence in secreted proteins and a motif implicated in extracellular protein interactions|url=https://www.sciencedirect.com/science/article/pii/002228369290891M|journal=Journal of Molecular Biology|language=en|volume=227|issue=2|pages=367–370|doi=10.1016/0022-2836(92)90891-M|issn=0022-2836}}</ref>


== Career and Research ==
== Career and Research ==

Revision as of 17:57, 2 July 2018

Rothberg, January 2008

Jonathan M. Rothberg (born 1963) is an American scientist and entrepreneur. He is the founder of CuraGen[1], 454 Life Sciences, RainDance Technologies[2], Ion Torrent Systems,[3] Butterfly Network,[4] and the medical device incubator 4Catalyzer.[5] Rothberg is best known for his contributions to next-generation DNA sequencing. He was awarded the National Medal of Technology and Innovation by President Barack Obama in 2015 for his “pioneering inventions and commercialization of next-generation DNA sequencing technologies, making access to genomic information easier, faster and more cost-effective for researchers around the world."[6]

Early Life and Education

Rothberg was born in New Haven, CT[7] to Lillian Rothberg and Henry Rothberg, a chemical engineer who invented a new way of laying ceramic tile and founded Laticrete International, Inc., to commercialize it.[1] Rothberg earned a BS in Chemical Engineering with an option in Biomedical Engineering from Carnegie Mellon University in 1985[8] and went on to earn a MS, M.Phil., and Ph.D. in biology at Yale University.[8] His graduate work at Yale focused on sequencing the 9,000-base gene Slit, a project that took him six years and earned him the John Spangler Nicholas Prize for Outstanding Doctoral Candidate in 1991.[9][10]

Career and Research

CuraGen

While a graduate student at Yale in 1991, he founded CuraGen, one of the first genomics companies. CuraGen focused on how the proteins encoded in a genome function together, and published the first global proteomic maps of a eukaryotic cell and a metazoan organism (featured on the covers of Nature and Science) and developed drugs for the treatment of metastatic skin and breast cancer. However, after never bringing a drug to market, CellDex Therapeutics acquired CuraGen in 2009 and reduced it to only five employees by October.[11]

454 Life Sciences

In 2000 454 Life Sciences was founded as a subsidiary of Curagen; Rothberg was the CEO of Curagen at the time.[12] It was acquired by Roche Diagnostics in 2007 then closed down by Roche in 2013 after other approaches to sequencing rendered the underlying technology noncompetitive.[13]

Rothberg brought to market a machine for massively parallel DNA sequencing. 454 Life Sciences and the Baylor College of Medicine Genome Center was the first to complete and make public the sequence of an individual human genome (James D. Watson[14][15]). Published in Nature magazine, that genome was made publicly on GenBank and browsable via the efforts of Lincoln Stein's group [16] contributing to personal genomics. Rothberg initiated the Neanderthal Genome Project in collaboration with Svante Pääbo's group.[17]

RainDance Technologies

Rothberg founded RainDance Technologies, which used droplet-based microfluidics.[citation needed]

Ion Torrent

Rothberg founded Ion Torrent in 2007, who developed ion semiconductor sequencing which is utilized by their PGM DNA sequencer.[18]

Rothberg Institute and Foundation for Childhood Diseases

Rothberg founded the Rothberg Institute for Childhood Diseases in 2002.[19] He and his wife Bonnie Gold-Rothberg have five children. One of them was affected by the rare genetic disease tuberous sclerosis, and the non-profit institute specialized in treating that disease.[20] The institute ran a distributed computing project called Community TSC until April 2009.[21] The TSC project was based on technology known as the Drug Design and Optimization Lab (D2OL), which the institute sponsored through 2009, to use volunteers' personal computers to model interactions of drug candidates with their target molecules.[22]

Recognition

  • 2015: The National Medal of Technology and Innovation for "pioneering inventions and commercialization of next generation DNA sequencing technologies, making access to genomic information easier, faster, and more cost-effective for researchers around the world."[23]
  • 2015: The World Economic Forum’s Technology Pioneer, for Butterfly Network Ultrasound on a chip[24]
  • 2014: John A. Quinn Lecture in Chemical Engineering, University of Pennsylvania[25]
  • 2012: Wilbur Cross Medal for most distinguished alumni, Yale University[26]
  • 2011: DGKL Biochemical Analysis Prize for development of massively parallel DNA sequencing
  • 2011: Doctor of Science Honoris Causa Mount Sinai School of Medicine for inventing massively parallel DNA sequencing[27]
  • 2010: The World Economic Forum’s Technology Pioneer, for the Ion Torrent Semiconductor Sequencing[28]
  • 2010: Connecticut Medal of Technology for inventing Next-Generation sequencing[29]
  • 2009: $2.2 Million NIH/NHGRI technology development award to ION for the $1,000 genome[30]
  • 2008: The World Economic Forum’s Technology Pioneer, for the Raindance microfluidics system[31]
  • 2007: The World Economic Forum’s Technology Pioneer, for 454 Life Sciences' invention of Next-Gen Sequencing[32]
  • 2006: R & D 100 Awards to 454 Life Sciences[33]
  • 2005: Wall Street Journal 2005 Technology Innovation Awards, Gold Medal Winner for inventing Next Generation sequencing[34]
  • 2005: Member Connecticut Academy of Science and Engineering[35]
  • 2004: National Academy of Engineering[36]
  • 2000: The Irvington Institute’s Corporate Leadership Award in Science[37]
  • 1998: Ernst and Young Entrepreneur of the Year[38]

References

  1. ^ a b Pollack, Andrew (2011-01-04). "Rothberg Seeks to Make DNA Sequencing Common". The New York Times. Retrieved 2018-05-22.
  2. ^ "List of Technology Pioneers 2008". World Economic Forum. Retrieved 2018-06-27.
  3. ^ Pollack, Andrew (2011). "Taking DNA Sequencing to the Masses". The New York Times. The New York Times. Retrieved May 20, 2018.
  4. ^ Lurye, Rebecca. "Starting With Ultrasound, An Innovation Empire Is Growing In Guilford". courant.com. Retrieved 2018-05-22.
  5. ^ Hoffman, Christopher (2015-02-01). "Guilford incubator 4Catalyzer aims for game-changing medical products". New Haven Register. Retrieved 2018-06-05.
  6. ^ Rothberg. "NMTI Laureate". {{cite web}}: Cite has empty unknown parameter: |dead-url= (help)
  7. ^ Bails, Jennifer (2012). "He Did It | Carnegie Mellon Today". www.cmu.edu. Retrieved 2018-06-20. {{cite web}}: |archive-date= requires |archive-url= (help); Cite has empty unknown parameter: |dead-url= (help)
  8. ^ a b "Jonathan M. Rothberg Ph.D.: Executive Profile & Biography - Bloomberg". www.bloomberg.com. Retrieved 2018-05-25.
  9. ^ Rothberg, Jonathan Marc; Hartley, David A.; Walther, Zenta; Artavanis-Tsakonas, Spyros (1988-12-23). "slit: An EGF-homologous locus of D. melanogaster involved in the development of the embryonic central nervous system". Cell. 55 (6): 1047–1059. doi:10.1016/0092-8674(88)90249-8. ISSN 0092-8674.
  10. ^ "Modularity of the slit protein: Characterization of a conserved carboxy-terminal sequence in secreted proteins and a motif implicated in extracellular protein interactions". Journal of Molecular Biology. 227 (2): 367–370. 1992-09-20. doi:10.1016/0022-2836(92)90891-M. ISSN 0022-2836.
  11. ^ Eric Gerson (October 10, 2009). "A Smaller CuraGen Corp. To Stay Open In Branford". The Hartford Courant. Retrieved November 14, 2016.
  12. ^ "Curagen Form 10-K for the fiscal year ended December 31, 2000". SEC.
  13. ^ Hollmer, Mark (October 17, 2013). "Roche to close 454 Life Sciences as it reduces gene sequencing focus". Fierce Biotech.
  14. ^ Project Jim: Watson’s Personal Genome Goes Public at Bio-IT World.com
  15. ^ Nicholas Wade (May 31, 2007). "Genome of DNA Pioneer Is Deciphered". The New York Times. Retrieved November 14, 2016.
  16. ^ James Watson's Personal Genome Sequence Archived 2008-12-03 at the Wayback Machine
  17. ^ Analysis of one million base pairs of Neanderthal DNA at Nature.com
  18. ^ Ion Torrent Official Webpage. Archived 2012-11-06 at the Wayback Machine
  19. ^ "Sharing a home, a family and science—two alumni try to make a difference". Yale Medicine Alumni Notes. January 2007. Archived from the original on May 9, 2007. Retrieved November 14, 2016.
  20. ^ Andrew Pollack (January 4, 2011). "Taking DNA Sequencing to the Masses". The New York Times. Retrieved November 14, 2016.
  21. ^ "The End of an Era". Rothberg Institute for Childhood Diseases. April 9, 2009. Archived from the original on February 16, 2009. Retrieved November 14, 2016. {{cite web}}: Unknown parameter |deadurl= ignored (|url-status= suggested) (help)
  22. ^ "On April 15, 2009, the D2OL distributed computing project will officially end operations". D2OL web site. Archived from the original on April 19, 2009. Retrieved November 14, 2016. {{cite web}}: Unknown parameter |deadurl= ignored (|url-status= suggested) (help)
  23. ^ "President Obama to Honor Nation's Leading Scientists and Innovators". whitehouse.gov. 2015-12-22. Retrieved 2018-06-20.
  24. ^ "World Economic Forum's 2015 Tech Pioneers tackle energy, finance and health; US companies lead the charge". World Economic Forum. Retrieved 2018-06-04.
  25. ^ "CBE - Quinn Lecture Series". www.cbe.seas.upenn.edu. Retrieved 2018-06-04.
  26. ^ "Graduate School Honors Four Alumni with Wilbur Cross Medals | Yale Graduate School of Arts & Sciences". gsas.yale.edu. Retrieved 2018-06-04.
  27. ^ "Genomics and Precision Medicine Pioneer Jonathan Rothberg to Deliver Connected Health Conference Keynote on Transforming Healthcare with Semiconductors and Artificial Intelligence | Personal Connected Health Alliance". www.pchalliance.org. Retrieved 2018-06-04.
  28. ^ "World Economic Forum Technology Pioneers 2010". World Economic Forum. Retrieved 2018-06-04.
  29. ^ "Connecticut Medal of Science, Connecticut Medal of Technology". www.ctcase.org. Retrieved 2018-06-04.
  30. ^ "Advanced Sequencing Technology Awards 2009". National Human Genome Research Institute (NHGRI). Retrieved 2018-06-05.
  31. ^ "List of Technology Pioneers 2008". World Economic Forum. Retrieved 2018-06-04.
  32. ^ "List of Technology Pioneers 2007". World Economic Forum. Retrieved 2018-06-04.
  33. ^ "2006 R & D 100 Award Winners". Research & Development. 2006-08-31. Retrieved 2018-06-04.
  34. ^ Totty, Michael (2005-10-24). "A Better Idea". Wall Street Journal. ISSN 0099-9660. Retrieved 2018-06-04.
  35. ^ "Connecticut Academy of Science & Engineering - Member public profile". casemembers.wildapricot.org. Retrieved 2018-06-04.
  36. ^ "Dr. Jonathan M. Rothberg". NAE Website. Retrieved 2018-06-04.
  37. ^ "Jonathan Rothberg, PhD - World Medical Innovation Forum BOSTON". World Medical Innovation Forum BOSTON. Retrieved 2018-06-05.
  38. ^ Corporation, Life Technologies. "Ion Torrent CEO Jonathan Rothberg, Life Technologies Recognized by Wall Street Journal Technology Innovation Awards for the Ion Personal Genome Machine". www.prnewswire.com. Retrieved 2018-06-05.
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