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Update for recent allegations of reviewer and editorial misconduct.
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== Recognition ==
== Recognition ==
Chou's papers have been widely cited. According to [[Web of Science]], his [[h-index]] is over 134<ref>{{Cite web|url=https://publons.com/researcher/1332069/kuo-chen-chou/|title=Kuo-Chen Chou's Publons profile|website=publons.com}}</ref>. He has been continuously for 5 years (2014, 2015, 2016, 2017 and 2018) selected by [[Thomson Reuters]] and [[Clarivate Analytics]] as [[ISI Highly Cited Researcher]].<ref>{{Cite web|url=https://gordonlifescience.org/honors/11_2018_HiCi-certificate.pdf|title=Archived HCR Lists}}</ref><ref>{{Cite web|url=https://gordonlifescience.org/honors/10_2017_HiCi-certificate1.pdf|title=Archived HCR Lists}}</ref><ref>{{Cite web|url=https://gordonlifescience.org/honors/9_2017_HiCi-certificate2.pdf|title=Archived HCR Lists}}</ref><ref>{{Cite web|url=https://gordonlifescience.org/honors/8_2016_HiCiCertificate.pdf|title=Archived HCR Lists}}</ref><ref>{{Cite web|url=https://gordonlifescience.org/honors/6_2014_HiCiCeriticate.pdf|title=Archived HCR Lists}}</ref>
Chou's papers have been widely cited. According to [[Web of Science]], his [[h-index]] is over 134<ref>{{Cite web|url=https://publons.com/researcher/1332069/kuo-chen-chou/|title=Kuo-Chen Chou's Publons profile|website=publons.com}}</ref>. He has been continuously for 5 years (2014, 2015, 2016, 2017 and 2018) selected by [[Thomson Reuters]] and [[Clarivate Analytics]] as [[ISI Highly Cited Researcher]].<ref>{{Cite web|url=https://gordonlifescience.org/honors/11_2018_HiCi-certificate.pdf|title=Archived HCR Lists}}</ref><ref>{{Cite web|url=https://gordonlifescience.org/honors/10_2017_HiCi-certificate1.pdf|title=Archived HCR Lists}}</ref><ref>{{Cite web|url=https://gordonlifescience.org/honors/9_2017_HiCi-certificate2.pdf|title=Archived HCR Lists}}</ref><ref>{{Cite web|url=https://gordonlifescience.org/honors/8_2016_HiCiCertificate.pdf|title=Archived HCR Lists}}</ref><ref>{{Cite web|url=https://gordonlifescience.org/honors/6_2014_HiCiCeriticate.pdf|title=Archived HCR Lists}}</ref>

==Controversy==

In early 2020, allegations of reviewer-coerced citation came to light at the [[Bioinformatics_(journal)|Bioinformatics]] journal<ref>{{cite journal |last1=Wren |first1=Jonathan D |last2=Valencia |first2=Alfonso |last3=Kelso |first3=Janet |title=Reviewer-coerced citation: case report, update on journal policy and suggestions for future prevention |journal=Bioinformatics |date=15 September 2019 |volume=35 |issue=18 |pages=3217–3218 |doi=https://doi.org/10.1093/bioinformatics/btz071 |accessdate=31 January 2020}}</ref>. Following these allegations, Chou has been removed from the editorial board of [[Theoretical Population Biology]] effective March 2020 as announced in the advance online publication on 29 January 2020<ref>{{cite journal |title=Editorial Board |journal=Journal of Theoretical Biology |date=March 2020 |volume=488 |pages=110168 |doi=https://doi.org/10.1016/S0022-5193(20)30024-2 |accessdate=31 January 2020}}</ref> at the time of investigations into editorial malpractice at the journal<ref>{{cite journal |last1=Chaplain |first1=Mark |last2=Kirschner |first2=Denise |last3=Iwasa |first3=Yoh |title=JTB Editorial Malpractice: A Case Report |journal=Journal of Theoretical Biology |date=March 2020 |volume=488 |pages=110171 |doi=https://doi.org/10.1016/j.jtbi.2020.110171}}</ref>. Therefore Chou's proliferative publication rate and h-index have come under scrutiny as they may be a result of this academic misconduct.


== References ==
== References ==

Revision as of 07:38, 31 January 2020

Kuo-Chen Chou
File:Kcchou.png
Born (1938-08-14) August 14, 1938 (age 86)
Guangdong, China[1]
NationalityAmerican
Alma mater
Scientific career
Fields
InstitutionsGordon Life Science Institute
ThesisLow-Frequency Motions of Protein Molecules (1984)
Websitegordonlifescience.org

Kuo-Chen Chou (周国城; born August 14, 1938) is a Chinese-American biophysicist and bioinformatician. Among other contributions, he is the developer of pseudo amino acid composition (PseAAC), widely used in computational biology for proteomics analysis and pseudo K-tuple nucleotide composition (PseKNC) for genome analysis.[citation needed] He is the father of James Chou.[2]

Chronology of research

In 1972, he and his co-workers, by taking into account the spatial factor and force field factor between the enzyme and its substrate, reported that the upper limit of diffusion-controlled reaction of enzyme or diffusion limited enzyme is one order of magnitude higher than the conventional estimation, and can be used to elucidate some surprisingly high reaction rates in molecular biology.[citation needed]

In 1977, he predicted the existence of low-frequency phonons in proteins, followed by developing the theory of low-frequency collective motion in proteins and DNA after it had been confirmed by Raman spectroscopy.[citation needed]

In 1995, he proposed and rigorously proved a theorem named as Chou's invariance theorem for addressing the problems often encountered in bioinformatics and cheminformatics.[citation needed]

In 1996, he proposed the distorted key theory for guiding how to design peptide drugs.[citation needed]

In 2011, he proposed the 5-step rules or 5-steps rule, that has been widely used for proteome and genome analyses as well as predicting posttranslational modification (PTM) sites in protein, RNA, and DNA sequences.[citation needed]

As of December 2019, Chou has published over 720 scientific papers in enzyme kinetics, graphical methods in biology, protein structure prediction and function, low-frequency collective motion in macromolecules, proteome and genome analyses, and identification of posttranslational modification sites in biological sequences.[3]

Recognition

Chou's papers have been widely cited. According to Web of Science, his h-index is over 134[4]. He has been continuously for 5 years (2014, 2015, 2016, 2017 and 2018) selected by Thomson Reuters and Clarivate Analytics as ISI Highly Cited Researcher.[5][6][7][8][9]

Controversy

In early 2020, allegations of reviewer-coerced citation came to light at the Bioinformatics journal[10]. Following these allegations, Chou has been removed from the editorial board of Theoretical Population Biology effective March 2020 as announced in the advance online publication on 29 January 2020[11] at the time of investigations into editorial malpractice at the journal[12]. Therefore Chou's proliferative publication rate and h-index have come under scrutiny as they may be a result of this academic misconduct.

References

  1. ^ Chou, Kuo Chen; Nemethy, George; Scheraga, Harold A. (May 30, 1990). "Energetics of interactions of regular structural elements in proteins". Accounts of Chemical Research. 23 (5): 134–141. doi:10.1021/ar00173a003.
  2. ^ "Flu-drug flap". The Scientist Magazine®.
  3. ^ "Kuo-Chen Chou - Google Scholar Citations". scholar.google.com.
  4. ^ "Kuo-Chen Chou's Publons profile". publons.com.
  5. ^ "Archived HCR Lists" (PDF).
  6. ^ "Archived HCR Lists" (PDF).
  7. ^ "Archived HCR Lists" (PDF).
  8. ^ "Archived HCR Lists" (PDF).
  9. ^ "Archived HCR Lists" (PDF).
  10. ^ Wren, Jonathan D; Valencia, Alfonso; Kelso, Janet (15 September 2019). "Reviewer-coerced citation: case report, update on journal policy and suggestions for future prevention". Bioinformatics. 35 (18): 3217–3218. doi:https://doi.org/10.1093/bioinformatics/btz071. {{cite journal}}: |access-date= requires |url= (help); Check |doi= value (help); External link in |doi= (help)
  11. ^ "Editorial Board". Journal of Theoretical Biology. 488: 110168. March 2020. doi:https://doi.org/10.1016/S0022-5193(20)30024-2. {{cite journal}}: |access-date= requires |url= (help); Check |doi= value (help); External link in |doi= (help)
  12. ^ Chaplain, Mark; Kirschner, Denise; Iwasa, Yoh (March 2020). "JTB Editorial Malpractice: A Case Report". Journal of Theoretical Biology. 488: 110171. doi:https://doi.org/10.1016/j.jtbi.2020.110171. {{cite journal}}: Check |doi= value (help); External link in |doi= (help)
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