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Jennifer Prescher

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Jennifer Prescher
Born
Jennifer Ann Prescher
Alma materUniversity of Wisconsin–La Crosse (BS)
University of California, Berkeley (PhD)
AwardsNational Science Foundation CAREER Award (2014)
Sloan Research Fellowship (2015)
Scientific career
FieldsChemistry
InstitutionsStanford University
University of California, Irvine
ThesisProbing glycosylation in living animals with bioorthogonal chemistries (2006)
Doctoral advisorCarolyn Bertozzi[1]
Websitewww.chem.uci.edu/people/jennifer-prescher Edit this at Wikidata

Jennifer Ann Prescher is an American chemist who is a professor of chemistry at the University of California, Irvine. Her research considers the development of bioorthogonal, bioluminescent tools for the noninvasive, real-time imaging of immunometabolism.[2] She was recognized with the 2023 American Chemical Society Arthur C. Cope Scholar Award.[3]

Early life and education

Prescher was an undergraduate in chemistry at the University of Wisconsin–La Crosse. She moved to California as a doctoral researcher, and was appointed to the University of California, Berkeley as a Howard Hughes Medical Institute predoctoral fellow, where she worked with Carolyn Bertozzi on glycosylation.[1] She developed a strategy to visualize the glycosylation process, which allowed for the design and development of novel diagnostics. The strategy relied upon the use of bioorthogonal chemistries. Specifically, she showed that it was possible to incorporate metabolic precursor sugars with specific chemical functionalities into target glycans. For example, biologically inert azides can be incorporated into glycans and chemically modified with exogenously delivered probes.[1]

Research and career

In 2008, she joined Stanford University as a Susan Komen postdoctoral fellow.[citation needed] Prescher joined the University of California, Irvine in 2010, and was made a full professor in 2018. Her early work looked to design imaging techniques to better understand cell movements and metastatic disease.[4] She worked on bioluminescent tools; tools which luminesce when they come into close proximity to cancer cells.[4][5][6] She called the technique a biological flashlight, or phasor.[7]

Awards and honors

Selected publications

  • A Comparative Study of Bioorthogonal Reactions with Azides[17]
  • A strain-promoted [3 + 2] azide-alkyne cycloaddition for covalent modification of biomolecules in living systems[18]
  • Chemistry in living systems[19]

References

  1. ^ a b c Prescher, Jennifer Ann (2006). Probing glycosylation in living animals with bioorthogonal chemistries. berkeley.edu (PhD thesis). University of California, Berkeley. OCLC 892833679. ProQuest 305348554.
  2. ^ Jennifer Prescher publications from Europe PubMed Central
  3. ^ "ACS 2023 National Award winners". cen.acs.org. Retrieved 2022-11-04.
  4. ^ a b c "NSF Award Search: Award # 1351302 - CAREER: Engineered bioluminescent tools for visualizing metastatic disease". nsf.gov. Retrieved 2022-06-19.
  5. ^ "Bioluminescent tools for noninvasive, real-time imaging of immunometabolism". alleninstitute.org. Retrieved 2022-06-19.
  6. ^ "Research". chem.uci.edu. Retrieved 2022-06-19.
  7. ^ a b "Professor Prescher named a Paul G. Allen Frontiers Group Distinguished Investigator | UCI Department of Chemistry". chem.uci.edu. Retrieved 2022-06-19.
  8. ^ "2014 Kavli Fellows - News Release". nasonline.org. Retrieved 2022-06-19.
  9. ^ "2015 Sloan Research Fellowships go to two UCI chemistry faculty members". UCI News. 2015-02-28. Retrieved 2022-06-19.
  10. ^ "Novartis Early Career Award: B. L. Pentelute and J. A. Prescher / Biotrans Award: W. Kroutil / Carus Medal: H. J. Wörner". Angewandte Chemie International Edition. 54 (50): 15012. 2015-12-07. doi:10.1002/anie.201509775.
  11. ^ "Previous Winners - Thieme Chemistry - Georg Thieme Verlag". Thieme. Retrieved 2022-06-19.
  12. ^ "2016 News". chem.uci.edu. Retrieved 2022-06-19.
  13. ^ "Faculty Awards | UCI Department of Chemistry". chem.uci.edu. Retrieved 2022-06-19.
  14. ^ "Scialog Fellow (Research Corporation) | UCI Department of Chemistry". chem.uci.edu. Retrieved 2022-06-19.
  15. ^ "Investigators". alleninstitute.org. Retrieved 2022-06-19.
  16. ^ "ACS 2023 National Award winners". cen.acs.org. Retrieved 2022-11-04.
  17. ^ Nicholas J. Agard; Jeremy M. Baskin; Jennifer A. Prescher; Anderson Lo; Carolyn R. Bertozzi (November 2006). "A Comparative Study of Bioorthogonal Reactions with Azides". ACS Chemical Biology (in English and English). 1 (10): 644–648. doi:10.1021/CB6003228. ISSN 1554-8929. PMID 17175580. Wikidata Q54279492.
  18. ^ Nicholas J Agard; Jennifer A Prescher; Carolyn R Bertozzi (24 November 2004). "A strain-promoted [3 + 2] azide-alkyne cycloaddition for covalent modification of biomolecules in living systems". Journal of the American Chemical Society. 126 (46): 15046–7. doi:10.1021/JA044996F. ISSN 0002-7863. PMID 15547999. Wikidata Q28293869.
  19. ^ Jennifer A Prescher; Carolyn R Bertozzi (June 2005). "Chemistry in living systems". Nature Chemical Biology. 1 (1): 13–21. doi:10.1038/NCHEMBIO0605-13. ISSN 1552-4450. PMID 16407987. Wikidata Q28291334.
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