Sayantani Ghosh as Satyavati: King Shantanu's second wife; Bhishma's step-mother; Ved Vyasa, Chitragada and Vichitravirya's mother
Atul Mishra as Ved Vyas: Satyavati and Maharishi Parashara's son; Dhritarashtra, Pandu and Vidura's surrogate father; Mahabharata's author
Aparna Dixit as Ambika: Vichitravirya's first wife and Dhritarashtra's mother
Thakur Anoop Singh as Dhritarashtra: Blind King of Hastinapur. Ved Vyasa and Ambika's son; Pandu and Vidura's elder half brother; Gandhari's husband; Kauravas and Dushala's father; Pandavas paternal uncle
Riya Deepsi as Gandhari: King Subala and Queen Sudharma's daughter; Princess of Gandhara; Shakuni's younger sister; Dhritarashtra's wife; Kauravas and Dushala's mother
Arpit Ranka as Duryodhan: Eldest Kaurava; King Dhritarashtra and Queen Gandhari's first son; Shakuni's nephew; Karna and Ashwathama's friend. Killed by Bheema on the 18th day
Nirbhay Wadhwa as Dushasana: Second Kaurava, King Dhritarashtra and Queen Gandhari's second son, Duryodhana's younger brother, 98 Kauravas and Dushala's elder brother, Killed by Bheema on the 16th day
Sandeep Arora as Vikarna: Third Kaurava prince, King Dhritarashtra and Queen Gandhari's third son and Duryodhan and Dushasna's younger brother, Dushala's elder brother
Garima Jain / Aditi Rathore as Dushala "Avni" "Ananya" "Nilanjana" - Owner at Sukoon house; King Dhritarashtra and Queen Gandhari's daughter, Pandavas and Kauravas' sister, Jayadrath's wife and Mishti and Mowgoli's mother
Arsheen Naamdaar as Child Avni Mehta (2016–2017)
Karam Rajpal as Vidyut "Jaydrath" Pandit – Ragini's son; Avni's husband; Mishti and Mowgoli's father (2017–2018)
Payal Bhojwani as Mishti "Sayesha" Pandit Kapoor– Avni and Vidyut's daughter; Mowgli's elder sister; Karan's wife (2018)
Aayesha Vindhara as Child Mishti Pandit (2017–2018)
Zaan Khan as Karan "KK" Kapoor – Film superstar; Kamini and Sharad's son; Mishti's husband (2018)
Kabir Shah as Mowgli "Pillu" Pandit – Avni and Neil's son; Mishti's younger brother (2018)
Mansi Sharma as Ambalika: Vichitravirya's second wife and Pandu's mother
Arun Singh Rana as Pandu: Ambalika and Vyasa's son, Kunti and Madri's husband, Pandavas's father, King of Hastinapur
Shafaq Naaz as Kunti: Shurasena's daughter; Kuntibhoj's foster daughter; Vasudev's sister; Balarama, Krishna, and Subhadra's paternal aunt; King Pandu's first wife; Karna, Yudhisthira, Bhima and Arjuna's mother; Nakula and Sahadeva's step mother; Dowager Queen of Hastinapur.
Rohit Bhardwaj as Yudhishthira: First Pandava Prince; A truthful King; Dharmaraj spiritual son; Pandu and Kunti's son; Karna's younger brother; Bheem, Arjun's elder brother; Nakula and Sahadeva's elder half brother; He ruled Indraprastha and later Hastinapur
Saurav Gurjar as Bhima: Second Pandava Prince; Vayu's spiritual son; a tremendous mace fighter Pandu and Kunti's son; Karna and Yudhishthira's younger brother; Arjuna's elder brother; Nakula and Sahadeva's elder half brother; Hidimbi and Valandhara's husband; Ghatothkacha and Sarvaga's father
Shaheer Sheikh as Arjuna "Paarth": Third Pandava prince; Supreme archer; Indra's spiritual son; Pandu and Kunti's son; Karna, Yudhishthir, Bheem's younger brother; Nakul and Sahadev's elder half brother; Draupadi, Ulupi, Chitrangadha and Subhadra's husband; Shrutakarma, Shrutakirti, Iravan, Babruvahana and Abhimanyu's father; Uttara's teacher and father in law; Parikshit's grandfather
Suhani Dhanki as Madri: Princess of Madra and King Pandu's second wife and Nakul and Sahadev's mother
Vin Rana as Nakula: Fourth Pandava Prince; Ashwini Kumar Nastya's spiritual son; Pandu and Madri's son; Sahadev's twin elder brother; Kunti's first step son; Karna, Yudhishthira, Bheema and Arjuna younger half brother
Lavanya Bhardwaj as Sahadeva: Fifth Pandava Prince; Ashwini Kumar Darsa's spiritual son; Pandu and Madri's son; Nakul's twin younger brother; Kunti's second step son; Karna, Yudhishthira, Bheema and Arjuna's younger half brother
Naveen Jinger as Vidura: Prime minister of Hastinapur, Vyasa and Ambika and Ambalika's maid's Parishrami son, Dhritarashtra and Pandu's younger brother, Sulabha's husband
Karan Mehra / Vishal Singh as Naitik "Munna" Singhania: Gayatri and Rajshekhar's son; Devyani's step-son; Rashmi's brother; Naman and Muskaan's step-brother; Nandini's cousin; Anupama's second ex husband; Naksh and Naira's father; Kairav and Abhira's grandfather; Abhir's great-grandfather (2009–2018)
Yash Pandey as Child Naitik Singhania (2012)
Rohan Mehra / Rishi Dev / as Naksh "Chikku" "Lalla" "Duggu" "Nic" Singhania: Anupama and Naitik's son; Naira's brother; Yash's adopted cousin; Anmol's cousin; Mishti's step-cousin; Tara's ex-fiancé; Vansh's father (2012–present)
Harsh / Bani as Baby Naksh Singhania (2012)
Shivangi Joshi as Naira "Tina" "Kaira" "Radha" Singhania: Naitik's daughter; Naksh's sister; Nishant and Amrita's adoptive brother; Yash's adopted cousin; Anmol's cousin; Mishti's step-cousin; Tarun and Chandu's ex girlfriend; Duryodhana's wife; Kairav and Abhira's mother; Abhir's grandmother (2016–present)
Pahal Chaudhary / Avneet Kaur / Ayesha Singh as Mahi Gandhi: Kavya and Aniruddh's daughter; Vanraj's step daughter; Paritosh and Paakhi's step sister (2024-present)
Aman Maheshwari as Ahem Modi: Malti's student and accomplice; Kanak, Ramakant and Swara's father (2023)
Akanksha Juneja / Kreetika Sharma / Tanya Sharma as Kanak "Meera" Ulhas Rashim Chavan: Ahem's first daughter; Ramakant and Swara's elder sister; Sanskar's ex girlfriend; Pankaj's first ex wife; Surya's first wife; Gehna's rival (2020–present)
Rohit Suchanti as Ramakant "Ricky" Modi – Ahem's first son; Jaggi's step-son; Kanak and Swara's brother (2017)
Muskan Bamne / Rashmi Gupta / Chandani Sharma as Swara Modi: Ahem's second daughter; Kanak and Ramakant's younger sister; Pankaj's second ex wife; Surya's second wife; Gehna's sister cum rival
Manasvi Vashist as Ahem's second son (2020–2021)
Gaurav Khanna as Anuj "AK" Kapadia: A former business tycoon-turned-event manager; Malti Devi's son; Gopichand's foster son; Malvika's brother; Ankush's cousin; Maya and Shruti's fiancé; Sara, Aadhya and Bhairavi's foster father (2021–present)
Naksh Dhaval Adhyaru as Child Anuj Kapadia (2022)
Alma Hussein / Surbhi Chandna as Sara Kapadia: Ankush and Barkha's daughter; Adhik's niece and foster sister; Romil's half-sister; Anuj's foster daughter (2022)
