Talk:Γ-Butyrolactone

Chemicals Start‑class Mid‑importance

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I would question the research into whether it causes tooth decay. I did some searching on Google and found nothing about Tooth Decay and this substance. Perhaps ROS could source this information? Otherwise I will change it back.

Increased lactamase

"once someone has taken GBL a few times, the production of lactamase enzymes is increased" any reference? thanks ---- —Preceding unsigned comment added by 87.198.133.78 (talk) 02:55, 18 April 2009 (UTC)[reply]

Upon investigation, it seems that humans do not possess any sort of lactamase enzyme, however, there are enzymes discussed that act as lactonases. It seems that the section about lactamases, while providing some helpful information - which could prevent overdose, as it encourages people not to up their doses right away if they are not feeling the desired effects - is incorrect. Anecdotal evidence that I have come across does indicate that lack of enzymes does result in doses initially feeling weaker, however if this is the case then lactamases are not responsible (as these break down cyclic amides, something which GBL is not) and one would expect that some sort of lactonase (which break down cyclic esters, something which GBL is) is responsible. After a quick google search it seems that a lot of misinformation has been spread around the internet, a lot of websites seem to have copied information from each other, probably stemming from an original typo. However, there are a few websites that seem to state that lactonases are responsible, which would make a lot more sense, GHB Precursor information. I think this section should be re-written and the article that I have just linked (or others) could be used as a reference. As of now I have just replaced the word lactamase with lactonase.

Perfect analysis :-) thank you! --87.198.133.78 (talk) 14:22, 25 April 2009 (UTC)[reply]

Changes to the chemistry section

I removed some material for which I could not find references and added more specific information concerning the synthesis of GBL via bromine oxidation of THF. There is still much unreferenced information in this article. I haven't the time to clean it up at the moment, but I will hopefully get back to it in the future. Dextux 02:39, 16 December 2006 (UTC)[reply]

Solubility/Miscibility in/with water

Article states, that GBL is "moderatly soluble" in water; this is not true. It is, under wide range of temperature (at least 0 - 100°C) fully miscible with water, that is, it forms homogenous mixtures (solutions) with water in all possible ratios from 0.000000...1 to 99.99...9/100.--84.163.118.88 01:44, 20 February 2007 (UTC)[reply]

I changed that. Still not very happy with the first sentence though, especially the "oily" liquid part. Actually the whole article kind of sucks, I might just rewrite it. :/ number29 02:52, 12 April 2007 (UTC)[reply]

Innards

If ingested undiluted through the oral route, GBL can irritate innards.

Could we substitute a more precise definition for the unscientific "innards"? Presumably it irritates the esophagus and maybe the stomach. I don't want to change it myself though, as I'm not sure of the irritant mechanism.

Another minor issue: "ingested ... through the oral route" can be replaced by the simpler "swallowed" without any loss of meaning. Royhills 17:56, 24 July 2007 (UTC)[reply]

Question

I'm moving this from the article to here:

" Question: Would the the faster onset, cause more GHB to be produced in the body than expected? The consequence being higher levels of GHB in the body than expected, upon a re-introduction of the process. Suggestion: GHB should be limited as a function of time, by taking smaller amounts of GBL through out the process. Maintaining the normal amount of GHB, naturally found in the body, which can not be detected by screens. "

Weird.Miserlou (talk) 01:55, 11 December 2007 (UTC)[reply]

Contradiction regarding the duration of action

...GBL tends to be more potent and faster-acting than GHB, but has a shorter duration...GBL is longer acting and has a shorter onset than GHB.

Which one is it? --René van Buuren (talk) 22:22, 8 January 2009 (UTC)[reply]