Metabolite
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Metabolites are the intermediates and products of metabolism. The term metabolite is usually restricted to small molecules. Metabolites have various functions, including fuel, structure, signaling, stimulatory and inhibitory effects on enzymes, catalytic activity of their own (usually as a cofactor to an enzyme), defense, and interactions with other organisms (e.g. pigments, odorants, and pheromones). A primary metabolite is directly involved in normal "growth", development, and reproduction. Ethylene is an example of a primary metabolite produced in large-scale by industrial microbiology. A secondary metabolite is not directly involved in those processes, but usually has an important ecological function. Examples include antibiotics and pigments such as resins and terpenes etc. Some antibiotics use primary metabolites as precursors, such as actinomycin which is created from the primary metabolite, tryptophan. Some sugars that are metabolites; example: fructose or glucose in the metabolic pathways.
Examples of primary metabolites produced by industrial microbiology:[1]
| Class | Example |
|---|---|
| Alcohol | Ethanol |
| Amino acids | Glutamic acid, aspartic acid |
| Nucleotides | 5' guanylic acid |
| Antioxidants | Isoascorbic acid |
| Organic acids | Acetic acid, lactic acid |
| Polyols | Glycerol |
| Vitamins | B2 |
The metabolome forms a large network of metabolic reactions, where outputs from one enzymatic chemical reaction are inputs to other chemical reactions.
Metabolites from chemical compounds, whether inherent or pharmaceutical, are formed as part of the natural biochemical process of degrading and eliminating the compounds. The rate of degradation of a compound is an important determinant of the duration and intensity of its action. Profiling metabolites of pharmaceutical compounds, drug metabolism, is an important part of drug discovery, leading to an understanding of any undesirable side effects.
See also
- Secondary metabolite
- Antimetabolite
- Metabolic control analysis, a specific kind of control analysis
- Metabolome
- Metabolomics, the study of global metabolite profiles in a system (cell, tissue, or organism) under a given set of conditions
References
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