Talk:Nanosponges

This article was the subject of a Wiki Education Foundation-supported course assignment, between 13 January 2020 and 30 April 2020. Further details are available on the course page. Student editor(s): Lemkec2, Rangas4, Trzasg, Shylaniemann, Clarkb8 (article contribs).

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RPI WikiProject

The intention for this page is to expand on the information already present and to more in depth explain what a nanosponge is, how they work, and their differences in nature versus synthetically created nanosponges. We would like to expand on the applications already mentioned on the page as well as add some, primarily in biological and environmental application. Figures and pictures will be added to further understanding of this topic to readers. This page will be edited by five undergraduate engineering students who are currently enrolled in a BioMaterials class. This project is intended for us to learn more about a topic relating to biology in materials and sharing this with the science community by editing a wikipedia page we feel could benefit with information. We welcome any feedback, advice, or information from other wikipedia members! — Preceding unsigned comment added by Rangas4 (talk • contribs) 01:33, 5 March 2020 (UTC)[reply]

4/2/2020
The group has developed ideas for changes and additional sections we would like to add to this page. These are laid out in the outline below but are subject to change as the group continues its ongoing research about the topic.

Outline

Description

‘Definition’ and/or basic description
History

Mechanisms/Function

Cyclodextrin, crosslinked with a 3D network
Structure: cyclic glucopyranose oligomers and are synthesized by enzymatic
Movement: Prolonged acoustic propulsion (no biofueling)

Natural versus Synthetic

Natural: Liposome nanosponge (all-natural)
How we are now mimicking them synthetically

* Coatings (RBC & RBC-PL) 
* Nanorobots 
* RBC membranes and platelet membranes

Applications

Medical: Nanosponges coated with RBC for pore-forming toxin neutralization used for

* Drug delivery  
* Fight antibiotic resistance  
* Detoxification

Environmental

* Remove metal deposits from wastewater

Safety

* Chemical sensors
* Detection of explosives

Current Research

Current research is being conducted for use of nanosponges in treating bacterial infections, viral infections, autoimmune diseases, and venoms
Different than applications because these are things that are being developed but are not fully developed yet
Brain swelling reduced after injury being developed on mice
Nanorobots for removal of toxins
macrophage biomimetic nanoparticles for management of sepsis

Limitations of research

Hard to conduct human studies
No human patient studies have been conducted as of 2019
Nanoparticles are hard to develop
Human and synthetic components increase the complexity of development