Amikhelline: Difference between revisions

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+{{Short description|Chemical compound}}
 {{Drugbox
-| verifiedrevid = 443624272
+| verifiedrevid = 450346127
 | IUPAC_name = 9-(2-diethylaminoethoxy)-4-hydroxy-7-methylpyrano[3,2-f][1]benzoxol-5-one
-| image = Amikhelline.png
+| image = Amikhelline Structure.svg
-| width = 250
+| width =
 <!--Clinical data-->
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 | pregnancy_category =
 | legal_status =
 | routes_of_administration =
 <!--Pharmacokinetic data-->
@@ Line 16: / Line 17: @@
 | metabolism = none
 | elimination_half-life =
 | excretion =
 <!--Identifiers-->
+| CAS_number_Ref = {{cascite|correct|??}}
 | CAS_number = 4439-67-2
 | ATC_prefix = none
 | ATC_suffix =
 | ATC_supplemental =
+| ChEMBL = 2104025
 | PubChem = 71198
 | DrugBank_Ref = {{drugbankcite|correct|drugbank}}
@@ Line 33: / Line 36: @@
 <!--Chemical data-->
 | C=18 | H=21 | N=1 | O=5
-| molecular_weight = 331.363 g/mol
 | smiles = O=C/1c3c(O\C(=C\1)C)c(OCCN(CC)CC)c2occc2c3O
-| InChI = 1/C18H21NO5/c1-4-19(5-2)7-9-23-18-16-12(6-8-22-16)15(21)14-13(20)10-11(3)24-17(14)18/h6,8,10,21H,4-5,7,9H2,1-3H3
-| InChIKey = QZBPFSZZMYTRIA-UHFFFAOYAB
 | StdInChI_Ref = {{stdinchicite|correct|chemspider}}
 | StdInChI = 1S/C18H21NO5/c1-4-19(5-2)7-9-23-18-16-12(6-8-22-16)15(21)14-13(20)10-11(3)24-17(14)18/h6,8,10,21H,4-5,7,9H2,1-3H3
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 }}
-'''Amikhelline''' is an [[antimitotic]] drug.<ref>Turchini MF, Geneix A, Perissel B, Malet P, Turchini JP. Characterization of chromosomal aberrations induced in man by various antimitotic agents. (French). ''Comptes Rendus des Seances de la Societe de Biologie et de ses Filiales''. 1985;179(3):331-9. PMID 2417673</ref> It acts as a [[DNA intercalator]]<ref>Rucheton M, Jeanteur P. Studies on amikhellin. I. Intercalative binding to double-stranded DNA. ''Biochimie''. 1973;55(11):1415-20. PMID 4364376</ref> and inhibits [[DNA polymerase]].<ref>Rucheton M, Jeanteur P. Studies on amikhellin. II.-Inhibition of dna-polymerase from murine sarcoma leukemia virus. ''Biochimie''. 1976;58(6):689-95. PMID 60141</ref>
+'''Amikhelline''' is an [[antimitotic]] drug.<ref>{{cite journal | vauthors = Turchini MF, Geneix A, Perissel B, Malet P, Turchini JP | title = [Characterization of chromosomal aberrations induced in man by various antimitotic agents] | journal = Comptes Rendus des Séances de la Société de Biologie et de ses Filiales | volume = 179 | issue = 3 | pages = 331–9 | pmid = 2417673 | year = 1985 }}</ref> It acts as a [[DNA intercalator]]<ref>{{cite journal | vauthors = Rucheton M, Jeanteur P | title = Studies on amikhellin. I. Intercalative binding to double-stranded DNA | journal = Biochimie | volume = 55 | issue = 11 | pages = 1415–20 | pmid = 4364376 | doi = 10.1016/s0300-9084(74)80548-1 | year = 1973 }}</ref> and inhibits [[DNA polymerase]].<ref>{{cite journal | vauthors = Rucheton M, Jeanteur P | title = Studies on amikhellin. II.-Inhibition of dna-polymerase from murine sarcoma leukemia virus | journal = Biochimie | volume = 58 | issue = 6 | pages = 689–95 | pmid = 60141 | doi = 10.1016/s0300-9084(76)80393-8 | year = 1976 }}</ref>
+== References ==
+{{reflist}}
+[[Category:Antineoplastic and immunomodulating drugs]]
-==References==
+[[Category:Benzofuran ethers at the benzene ring]]
-<references/>
+[[Category:Furanochromones]]
+[[Category:DNA intercalaters]]
+[[Category:DNA polymerase inhibitors]]
+[[Category:Diethylamino compounds]]