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{{Short description|Antihypertensive medication}}
{{Use dmy dates|date=February 2024}}
{{Drugbox
{{Drugbox
| Verifiedfields = changed
| Watchedfields = changed
| Watchedfields = changed
| verifiedrevid = 398777189
| verifiedrevid = 415479203
| type = combo
| type = combo
| image = Amlodipine.svg
| image = Amlodipine.svg
| alt =
| image2 = Benazepril.svg
| image2 = Benazepril.svg
| component1 = Amlodipine
| alt2 =
| class1 = [[Calcium channel blocker]]

| component2 = Benazepril
<!-- Combo data -->
| class2 = [[ACE inhibitor]]
| component1 = Amlodipine
| class1 = [[Calcium channel blocker]]
| component2 = Benazepril
| class2 = [[ACE inhibitor]]

<!-- Clinical data -->
| tradename = Lotrel
| Drugs.com = {{drugs.com|ppa|amlodipine-and-benazepril}}
| DailyMedID = Amlodipine and benazepril
| pregnancy_AU = <!-- A / B1 / B2 / B3 / C / D / X -->
| pregnancy_category =
| routes_of_administration = [[Oral administration|By mouth]]
| ATC_prefix = C09
| ATC_suffix = BB13

<!-- Legal status -->
| legal_AU = <!-- S2, S3, S4, S5, S6, S7, S8, S9 or Unscheduled -->
| legal_AU_comment =
| legal_BR = <!-- OTC, A1, A2, A3, B1, B2, C1, C2, C3, C4, C5, D1, D2, E, F -->
| legal_BR_comment =
| legal_CA = <!-- OTC, Rx-only, Schedule I, II, III, IV, V, VI, VII, VIII -->
| legal_CA_comment =
| legal_DE = <!-- Anlage I, II, III or Unscheduled -->
| legal_DE_comment =
| legal_NZ = <!-- Class A, B, C -->
| legal_NZ_comment =
| legal_UK = <!-- GSL, P, POM, CD, CD Lic, CD POM, CD No Reg POM, CD (Benz) POM, CD (Anab) POM or CD Inv POM / Class A, B, C -->
| legal_UK_comment =
| legal_US = Rx-only
| legal_US_comment = <ref name="Lotrel FDA label">{{cite web | title=Lotrel- amlodipine besylate and benazepril hydrochloride capsule | work = DailyMed | publisher = U.S. National Library of Medicine | url=https://dailymed.nlm.nih.gov/dailymed/drugInfo.cfm?setid=94ae6054-b7ae-4212-a567-4f803af8f2c7 | access-date=20 June 2021}}</ref>
| legal_EU =
| legal_EU_comment =
| legal_UN = <!-- N I, II, III, IV / P I, II, III, IV -->
| legal_UN_comment =
| legal_status = <!-- For countries not listed above -->

<!-- Identifiers -->
| CAS_number_Ref = {{cascite|changed|??}}
| CAS_number = 357437-90-2
| PubChem = 5746247
| DrugBank =
| ChemSpiderID_Ref = {{chemspidercite|correct|chemspider}}
| ChemSpiderID_Ref = {{chemspidercite|correct|chemspider}}
| ChemSpiderID = 4676979
| ChemSpiderID = 4676979
| KEGG = D11069
| InChI = 1/C24H28N2O5.C20H25ClN2O5/c1-2-31-24(30)20(14-12-17-8-4-3-5-9-17)25-19-15-13-18-10-6-7-11-21(18)26(23(19)29)16-22(27)28;1-4-28-20(25)18-15(11-27-10-9-22)23-12(2)16(19(24)26-3)17(18)13-7-5-6-8-14(13)21/h3-11,19-20,25H,2,12-16H2,1H3,(H,27,28);5-8,17,23H,4,9-11,22H2,1-3H3/t19-,20-;/m0./s1
| smiles = Clc1ccccc1C2C(\C(=O)OC)=C(/N\C(=C2\C(=O)OCC)COCCN)C.O=C(OCC)[C@@H](N[C@@H]2C(=O)N(c1ccccc1CC2)CC(=O)O)CCc3ccccc3
| InChIKey = SRTZYSFUFGOMFR-FKLPMGAJBV
| StdInChI_Ref = {{stdinchicite|correct|chemspider}}
| StdInChI = 1S/C24H28N2O5.C20H25ClN2O5/c1-2-31-24(30)20(14-12-17-8-4-3-5-9-17)25-19-15-13-18-10-6-7-11-21(18)26(23(19)29)16-22(27)28;1-4-28-20(25)18-15(11-27-10-9-22)23-12(2)16(19(24)26-3)17(18)13-7-5-6-8-14(13)21/h3-11,19-20,25H,2,12-16H2,1H3,(H,27,28);5-8,17,23H,4,9-11,22H2,1-3H3/t19-,20-;/m0./s1
| StdInChIKey_Ref = {{stdinchicite|correct|chemspider}}
| StdInChIKey = SRTZYSFUFGOMFR-FKLPMGAJSA-N
| CAS_number =
| ATC_prefix = None
| ATC_suffix =
| PubChem = 5746247
| DrugBank =
| pregnancy_AU = <!-- A / B1 / B2 / B3 / C / D / X -->
| pregnancy_US = D
| pregnancy_category=
| legal_AU = <!-- Unscheduled / S2 / S3 / S4 / S5 / S6 / S7 / S8 / S9 -->
| legal_CA = <!-- / Schedule I, II, III, IV, V, VI, VII, VIII -->
| legal_UK = <!-- GSL / P / POM / CD / Class A, B, C -->
| legal_US = Rx-only
| legal_status =
| routes_of_administration = Oral
}}
}}
'''Amlodipine/benazepril''', marketed in the U.S. as '''Lotrel''' by [[Novartis]] and manufactured as a [[generic drug]] by [[Teva Pharmaceutical Industries|Teva]] and [[Sandoz]], is an [[antihypertensive]] medication which combines a [[calcium channel blocker]] ([[amlodipine]] besilate) with an [[angiotensin converting enzyme inhibitor]] ([[benazepril]]).<ref>[http://www.pharma.us.novartis.com/product/pi/pdf/lotrel.pdf Lotrel Prescribing Information]</ref> This drug, like similar combinations, is prescribed when either agent alone is not sufficient to bring a person's blood pressure down to target range. As a combination agent, Lotrel shares the [[adverse drug reaction|adverse reaction]] profile of both of its individual parts.<ref>Drugs.com: [http://www.drugs.com/lotrel.html Lotrel]</ref><ref>RxList.com: [http://www.rxlist.com/cgi/generic3/amlobenaz.htm Lotrel]</ref>


<!-- Definition and medical uses -->
== See also ==
'''Amlodipine/benazepril''', sold under the brand name '''Lotrel''' among others, is a [[fixed-dose combination]] medication used to treat [[high blood pressure]].<ref name="Lotrel FDA label" /> It is a combination of [[amlodipine]], as the besilate, a [[calcium channel blocker]], and [[benazepril]], an [[angiotensin converting enzyme inhibitor]].<ref name="Lotrel FDA label"/> It may be used if a single agent is not sufficient.<ref name="Lotrel FDA label"/> It is taken [[by mouth]].<ref name="Lotrel FDA label"/>
* [[Amlodipine]]
* [[Benazepril]]


<!-- Side effects and mechanisms -->
==References==
Common side effects include cough, dizziness, and swelling.<ref name="Lotrel FDA label"/> Serious side effects may include [[angioedema]], [[myocardial infarction]], [[high blood potassium]], [[liver problems]], and [[low blood pressure]].<ref name="Lotrel FDA label"/> Use in [[pregnancy]] is not recommended.<ref name="Lotrel FDA label"/> Amlodipine works by [[vasodilation|increasing the size of arteries]] while benazepril works by decreasing [[Renin–angiotensin system|renin-angiotensin-aldosterone system]] activity.<ref name="Lotrel FDA label"/>
{{Reflist}}


<!-- Society and culture -->
==External links==
The combination was approved for medical use in the United States in 1995.<ref name=MTM2019>{{cite web | author = Cerner Multum |title=Amlodipine and benazepril Uses, Side Effects & Warnings |url=https://www.drugs.com/mtm/amlodipine-and-benazepril.html |website=Drugs.com |access-date=10 March 2019 |language=en}}</ref> It is available as a [[generic medication]].<ref>{{cite book | vauthors = Bope ET, Kellerman RD |title=Conn's Current Therapy 2017 E-Book |date=2016 |publisher=Elsevier Health Sciences |isbn=978-0-323-44335-7 |page=124 |url=https://books.google.com/books?id=UitFDQAAQBAJ&pg=PT158 }}</ref> In 2021, it was the 150th most commonly prescribed medication in the United States, with more than 3{{nbsp}}million prescriptions.<ref>{{cite web | title=The Top 300 of 2021 | url=https://clincalc.com/DrugStats/Top300Drugs.aspx | website=ClinCalc | access-date=14 January 2024 | archive-date=15 January 2024 | archive-url=https://web.archive.org/web/20240115223848/https://clincalc.com/DrugStats/Top300Drugs.aspx | url-status=live }}</ref><ref>{{cite web | title = Amlodipine; Benazepril - Drug Usage Statistics | website = ClinCalc | url = https://clincalc.com/DrugStats/Drugs/AmlodipineBenazepril | access-date = 14 January 2024 }}</ref>
* [[Novartis]]: [http://www.pharma.us.novartis.com/products/name/lotrel.jsp Lotrel official website]

==Medical uses==
It is used to treat [[high blood pressure]].<ref name="Lotrel FDA label"/> It is not a first-line treatment.<ref>{{cite journal | vauthors = Faulkner MA, Hilleman DE | title = Amlodipine/benazepril: fixed dose combination therapy for hypertension | journal = Expert Opinion on Pharmacotherapy | volume = 2 | issue = 1 | pages = 165–178 | date = January 2001 | pmid = 11336577 | doi = 10.1517/14656566.2.1.165 | s2cid = 23021242 }}</ref>

== References ==
{{Reflist}}


{{Calcium channel blockers}}
{{ACE inhibitors}}
{{ACE inhibitors}}
{{Calcium channel blockers}}
{{Portal bar|Medicine}}


{{DEFAULTSORT:Amlodipine Benazepril}}
[[Category:Combination drugs]]
[[Category:Novartis]]
[[Category:Combination antihypertensive drugs]]
[[Category:Drugs developed by Novartis]]
[[Category:Prodrugs]]
[[Category:Prodrugs]]
[[Category:Wikipedia medicine articles ready to translate]]




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