Milbemycin oxime/lufenuron: Difference between revisions

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+{{Short description|Combination drug}}
 {{Drugbox
+| verifiedrevid = 408380655
-| type              = combo
-| component1        = Milbemycin oxime
+<!--Combo data-->
-| class1            = [[Endectocide]]
+| type = combo
-| component2        = Lufenuron
+| component1 = Milbemycin oxime
-| class2            = [[Ectoparasiticide]]
+| class1 = [[Endectocide]]
-| CAS_number        =
+| component2 = Lufenuron
-| ATCvet            = yes
+| class2 = [[Ectoparasiticide]]
-| ATC_prefix        = <!-- 'none' if uncategorised -->
-| ATC_suffix        =
+<!--Clinical data-->
-| PubChem           =
-| DrugBank          =
+| tradename =
+| Drugs.com = {{drugs.com|pro|sentinel_flavor_tabs}}
-| pregnancy_AU      =  <!-- A / B1 / B2 / B3 / C / D / X -->
-| pregnancy_US      =  <!-- A / B            / C / D / X -->
+| pregnancy_AU = <!-- A / B1 / B2 / B3 / C / D / X -->
+| pregnancy_US = <!-- A / B            / C / D / X -->
-| pregnancy_category=
+| pregnancy_category =
-| legal_AU =  <!-- S2, S3, S4, S5, S6, S7, S8, S9 or Unscheduled-->
-| legal_CA =  <!-- Schedule I, II, III, IV, V, VI, VII, VIII -->
+| legal_AU = <!-- S2, S3, S4, S5, S6, S7, S8, S9 or Unscheduled-->
-| legal_UK =  <!-- GSL, P, POM, CD, or Class A, B, C -->
+| legal_CA = <!-- Schedule I, II, III, IV, V, VI, VII, VIII -->
-| legal_US =  <!-- OTC / Rx-only / Schedule I, II, III, IV, V -->
+| legal_UK = <!-- GSL, P, POM, CD, or Class A, B, C -->
+| legal_US = <!-- OTC / Rx-only / Schedule I, II, III, IV, V -->
-| legal_status      =
+| legal_status =
 | routes_of_administration =
+<!--Identifiers-->
+| CAS_number = 182005-62-5
+| ATCvet = yes
+| ATC_prefix = <!-- 'none' if uncategorised -->
+| ATC_suffix =
+| PubChem =
+| DrugBank_Ref = {{drugbankcite|correct|drugbank}}
+| DrugBank =
+<!--Chemical data-->
 }}
-'''Sentinel Flavor Tabs''', manufactured by [[Novartis|Novartis Animal Health]], is a [[parasite]] control drug in which the [[active ingredient]], [[milbemycin oxime]], eliminates [[flea]]s and worms, while a second active ingredient, [[lufenuron]], arrests the development of eggs and [[larva]]e, preventing them from maturing and continuing the infestation of an animal.  Sentinel Flavor Tabs are registered for animal use only.  To achieve efficacy, the treatment is administered once monthly, together with food, in a dosage suitable for the weight of the affected animal.  The usual ratio is 500&nbsp;µg milbemycin and 10&nbsp;mg lufenuron/kg body weight.  Novartis indicates the proper dosage by color-coding the packages of Sentinel Tabs.<ref>[http://www.sentinel.novartis.us Novartis Animal Health - Sentinel Flavor Tabs],</ref>
+The combination '''milbemycin oxime/lufenuron''' (trade names '''Sentinel Flavor Tabs''', by [[Novartis|Novartis Animal Health]], and '''Program plus''') is a [[parasite]] control drug in which the [[active ingredient]], [[milbemycin oxime]], eliminates worms, while a second active ingredient, [[lufenuron]], arrests the development of eggs and [[larva]]e, preventing them from maturing and continuing the infestation of an animal.  This combination is registered for animal use only.  To achieve efficacy, the treatment is administered once monthly, together with food, in a dosage suitable for the weight of the affected animal.  The usual ratio is 500&nbsp;μg milbemycin oxime and 10&nbsp;mg lufenuron/kg body weight.  Novartis indicates the proper dosage by color-coding the packages.<ref>[http://www.sentinel.novartis.us Novartis Animal Health - Sentinel Flavor Tabs],</ref>
-Several 2002 studies by Novartis demonstrate that Sentinel Tabs compare favorably to other treatments, such as the moxidectrin injection.  Sentinel Tabs are considered effective in the elimination of fleas, and the prevention of infection from [[hookworm]] (Ancylostoma caninum), [[heartworm]] (Dirofilaria immitis), [[roundworm]]s, [[whipworm]]s (Trichuris vulpis), and ascarids (Toxocara canis and Toxascaris leonina).{{Fact|date=April 2009}}
+Several 2002 studies by Novartis demonstrate that milbemycin oxime/lufenuron compares favorably to some other treatments, such as the [[moxidectin]] injection.  The combination is considered effective in the elimination of fleas, and the prevention of infection from [[hookworm]] (''Ancylostoma caninum''), [[heartworm]] (''Dirofilaria immitis''), [[roundworm]]s, [[whipworm]]s (''Trichuris vulpis''), and ascarids (''[[Toxocara canis]]'' and ''[[Toxascaris leonina]]'').{{Citation needed|date=April 2009}} The USA FDA approval for Sentinel says "Concurrent use of insecticides may be necessary".<ref>[http://www.accessdata.fda.gov/scripts/animaldrugsatfda/details.cfm?dn=140-084 NADA number 140-084]</ref>  It is the concurrent use of Sentinel and [[nitenpyram]] (Capstar) that has an FDA-approved indication "to kill adult fleas".<ref>[http://www.accessdata.fda.gov/scripts/animaldrugsatfda/details.cfm?dn=140-204 NADA number 140-204]</ref>
+==Side effects==
-However, Sentinel Tabs can lead to a [[Adverse effect (medicine)|negative physical response]] in some animals, most dangerously those that test positively for heartworm disease before receiving the treatment.  Less serious side effects are an upset stomach or loss of appetite, various skin irritations, and mood changes.
+Milbemycin oxime/lufenuron can lead to a [[Adverse effect (medicine)|negative physical response]] in some animals, most severely those that have heartworm disease or weigh under 2 lbs. It is recommended that all dogs be tested for heartworm prior to taking the medication to minimize this risk. Serious side effects may include lethargy, weakness, stumbling, seizures, coma, excessive drooling, and wide dilated pupils. Less serious side effects are an upset stomach or loss of appetite, various skin irritations, and mood changes. <ref>{{Cite web| vauthors = Gollakner R |title=Milbemycin Oxime|url=https://vcacanada.com/know-your-pet/milbemycin-oxime| work = VCA Canada Hospitals }}</ref>
 ==References==
 {{Reflist}}
+{{DEFAULTSORT:Milbemycin oxime lufenuron}}
 [[Category:Antiparasitic agents]]
 [[Category:Veterinary drugs]]
-[[Category:Novartis brand names]]
+[[Category:Drugs developed by Novartis]]
-[[Category:Combination drugs]]
+[[Category:Combination antibiotics]]
 {{Veterinary-med-stub}}