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Alkylation is a chemical reaction that entails transfer of an alkyl group. The alkyl group may be transferred as an alkyl carbocation, a free radical,...

nitrosophenol ethers typically dealkylate to facilitate the isomerization. Nitroso tertiary anilines generally do not dealkylate in that way. Due to the stability...

methylcobalamin for use as cofactors. That is, methylcobalamin is first dealkylated and then regenerated. According to one author, it is important to treat...

properties. The other metabolites identified include a N-dealkylated metabolite, and an O-dealkylated 1/16 metabolite with a plasma half-life of 59 hours....

for half an hour to three hours. Lidocaine is about 95% metabolized (dealkylated) in the liver mainly by CYP3A4 to the pharmacologically active metabolites...

(2RNH2 → R2NH + NH3). And finally, quaternary ammonium salts can be dealkylated using ethanolamine: R4N+ + NH2CH2CH2OH → R3N + RN+H2CH2CH2OH Aminonaphthalenes...

compounds. JWH-018 and its N-dealkylated metabolite were only detected in small amounts, with hydroxylated N-dealkylated metabolites comprising the primary...

oxidation, and degradation of the ethyl-bridge yielding the O/N-bis-dealkylated metabolite, combinations thereof and further glucuronidation or sulfations...

liver enzymes CYP2C8 and, to a lesser extent, CYP3A4, hydroxylate and dealkylate the active substance, thereby inactivating it. Besides, ACT-333679 is...

chemical compounds. They can be used to form protecting groups and as N-dealkylating agents. They are listed as extremely hazardous substances. 'A new reagent...

alkylated with propylene to give isomers of cymene, which can be oxidatively dealkylated analogous to the cumene process. Another method, involves carbonylation...

available and is a strong Lewis acid. It is an excellent demethylating or dealkylating agent for the cleavage of ethers, also with subsequent cyclization, often...

of administration. It is absorbed slowly into the plasma. Macitentan dealkylates into the active metabolite aprocitentan (ACT-132577), which reaches its...

is alkylated with propene to give p-cymene, which can be oxidatively dealkylated in a manner similar to the cumene process. p-Cresol is consumed mainly...

relevant metabolites are O-debenzylated safinamide (NW-1199), the N-dealkylated amine which is then oxidized to a carboxylic acid (NW-1689), and the...

unchanged. The glucuronide metabolite is entirely inactive, while the N-dealkylated metabolite has minimal pharmacological activity.[citation needed] Nalmefene...

acetonitrile as the nitrile, 2-methylpyridine is obtained, which can be dealkylated to pyridine. The Kröhnke pyridine synthesis provides a fairly general...

strain, aromaticity-driven β-Me elimination can be effectively employed to dealkylate steroid derivatives and some other cyclohexyl compounds. β-aryl elimination...

rational to consider that ethcathinone would also be expected to be N-dealkylated upon its consumption to the more active drug cathinone that is more able...

6-tri-tert-butyl-4-hydroxy-2,5-cyclohexadienone. In acidic media, the hydroxydienone is dealkylated with the cleavage of the tert-butyl group in the 4-position to the 2...