Sex differences in medicine: Difference between revisions
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→Females: use more recent sources for psychogenic non-epileptic seizures (prev was 2005). They use "female" and "woman" interchangeably but they ultimately say such things as "female sex preponderance" and discuss the difference mostly in terms of "female" vs "male." |
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==Background== |
==Background== |
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Sex the differences between women and me in terms of their disease risk, diagnosis and response to treatment. A patient's sex has been increasingly recognized as one of the most important modulators of clinical decisions in those terms. A patient's sex has been increasingly recognized as one of the most important modulators of clinical decision making.<ref>{{cite journal |last1=Legato |first1=Marianne J. |last2=Johnson |first2=Paula A. |last3=Manson |first3=JoAnn E. |title=Consideration of Sex Differences in Medicine to Improve Health Care and Patient Outcomes |journal=JAMA |date=8 November 2016 |volume=316 |issue=18 |pages=1865 |doi=10.1001/jama.2016.13995}}</ref> Sex differences have been found across a broad range of disease areas, including many diseases which are sex-specific. The sex chromosome complement and sex hormone environment are known to be the primary constitutive difference between females and males. The imbalance of gene expression between the X and Y chromosomes is present within virtually all cells in the human body. Hormones are also thought to affect gene expression throughout the body, shaping differences in how males and females develop. Such differences in development are suspected to influence disease severity, susceptibility, and presentation between the sexes.<ref>{{cite journal |last1=Miller |first1=Leah R. |last2=Marks |first2=Cheryl |last3=Becker |first3=Jill B. |last4=Hurn |first4=Patricia D. |last5=Chen |first5=Wei‐Jung |last6=Woodruff |first6=Teresa |last7=McCarthy |first7=Margaret M. |last8=Sohrabji |first8=Farida |last9=Schiebinger |first9=Londa |last10=Wetherington |first10=Cora Lee |last11=Makris |first11=Susan |last12=Arnold |first12=Arthur P. |last13=Einstein |first13=Gillian |last14=Miller |first14=Virginia M. |last15=Sandberg |first15=Kathryn |last16=Maier |first16=Susan |last17=Cornelison |first17=Terri L. |last18=Clayton |first18=Janine A. |title=Considering sex as a biological variable in preclinical research |journal=The FASEB Journal |date=January 2017 |volume=31 |issue=1 |pages=29–34 |doi=10.1096/fj.201600781r}}</ref> It is suspected that many differences between the sexes are also influenced by social, environmental, and psychological factors which are difficult to tease apart from biological ones. |
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<ref name="DoesSexMatter"/> Many biological processes are modulated by environmental stimuli (e.g. hormone levels during puberty are influenced by environmental factors, which can alter the timing and intensity of puberty-associated physiological changes).<ref>{{cite journal |last1=Manotas |first1=María Carolina |last2=González |first2=Daniel Mauricio |last3=Céspedes |first3=Camila |last4=Forero |first4=Catalina |last5=Moreno |first5=Adriana Patricia Rojas |title=Genetic and Epigenetic Control of Puberty |journal=Sexual Development |date=2022 |volume=16 |issue=1 |pages=1–10 |doi=10.1159/000519039 |url=https://www.karger.com/Article/FullText/519039 |language=english |issn=1661-5425}}</ref> Such complex relationships between environment and biology are precisely why it is so difficult to separate sex differences from gender differences. |
<ref name="DoesSexMatter"/> Many biological processes are modulated by environmental stimuli (e.g. hormone levels during puberty are influenced by environmental factors, which can alter the timing and intensity of puberty-associated physiological changes).<ref>{{cite journal |last1=Manotas |first1=María Carolina |last2=González |first2=Daniel Mauricio |last3=Céspedes |first3=Camila |last4=Forero |first4=Catalina |last5=Moreno |first5=Adriana Patricia Rojas |title=Genetic and Epigenetic Control of Puberty |journal=Sexual Development |date=2022 |volume=16 |issue=1 |pages=1–10 |doi=10.1159/000519039 |url=https://www.karger.com/Article/FullText/519039 |language=english |issn=1661-5425}}</ref> Such complex relationships between environment and biology are precisely why it is so difficult to separate sex differences from gender differences. |
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Revision as of 23:05, 23 December 2021
| Part of a series on |
| Sex differences in humans |
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Sex differences in medicine include sex-specific diseases or conditions which occur only in people of one sex due to underlying biological factors (for example, prostate cancer in males or uterine cancer in females); sex-related diseases, which are diseases that are more common to one sex (for example, breast cancer and systemic lupus erythematosus which occur predominantly in females);[1] and diseases which occur at similar rates in males and females but manifest differently according to sex (for example, peripheral artery disease).[2]
Sex differences should not be confused with gender differences. The US National Academy of Medicine recognizes sex differences as biological at the chromosomal and anatomical levels, whereas gender differences are based on self-representation and other factors including biology, environment and experience.[3][4] That said, both biological and behavioural differences influence human health, and may do so differentially. Such factors can be inter-related and difficult to separate. Evidence-based approaches to sex and gender medicine try to examine the effects of both sex and gender as factors when dealing with medical conditions that may affect populations differently.[5][6][3]
As of 2021[update], over 10,000 articles had been published addressing sex and gender differences in clinical medicine and related literature.[citation needed] Sex and gender affect cardiovascular,[7] pulmonary[8] and autoimmune systems,[9][10] gastroenterology,[11][12] hepatology,[5] nephrology,[13] endocrinology,[14][15] haematology,[16] neurology,[17][18][19][20] pharmacokinetics, and pharmacodynamics.[21][22][6][3]
Sexually transmitted diseases, which have a significant probability of transmission through sexual contact, can be contracted by either sex. Their occurrence may reflect economic and social as well as biological factors, leading to sex differences in the transmission, prevalence, and disease burden of STDs.[23]
Historically, medical research has primarily been conducted using the male body as the basis for clinical studies. The findings of these studies have often been applied across the sexes, and healthcare providers have traditionally assumed a uniform approach in treating both male and female patients. More recently, medical research has started to understand the importance of taking sex into account as evidence increases that the symptoms and responses to medical treatment may be very different between sexes.[24]
Background
Sex the differences between women and me in terms of their disease risk, diagnosis and response to treatment. A patient's sex has been increasingly recognized as one of the most important modulators of clinical decisions in those terms. A patient's sex has been increasingly recognized as one of the most important modulators of clinical decision making.[25] Sex differences have been found across a broad range of disease areas, including many diseases which are sex-specific. The sex chromosome complement and sex hormone environment are known to be the primary constitutive difference between females and males. The imbalance of gene expression between the X and Y chromosomes is present within virtually all cells in the human body. Hormones are also thought to affect gene expression throughout the body, shaping differences in how males and females develop. Such differences in development are suspected to influence disease severity, susceptibility, and presentation between the sexes.[26] It is suspected that many differences between the sexes are also influenced by social, environmental, and psychological factors which are difficult to tease apart from biological ones. [4] Many biological processes are modulated by environmental stimuli (e.g. hormone levels during puberty are influenced by environmental factors, which can alter the timing and intensity of puberty-associated physiological changes).[27] Such complex relationships between environment and biology are precisely why it is so difficult to separate sex differences from gender differences.
Causes
Sex-related illnesses have various causes:[5]
- Genetic sex differences start at conception depending on whether an ovum fuses with a sperm cell carrying an X or a Y chromosome. This leads to sex-based differences at the molecular level for all male and female cells.[5]
- In males, the X chromosome carries only maternal imprints, while in females X chromosomes are present with both maternal and paternal imprints. In female cells, random processes of X-inactivation "turn off" the extra X chromosome. As a result, females, but not males, are mosaics. Female cells may express higher levels of some genes.[28][29][30]
- Sex differences at the chromosome and molecular level exist in all human cells, and persist life-long, independent of sex hormones in the body.[5]
- Sex-linked genetic conditions that differ in males and females may reflect the effects of genetic damage on an X chromosome. In some cases, the presence of an "extra" X chromosome in female cells may lessen the impact of such damage. In severe cases, males may die during development and females may survive but display a sex-linked illness.[28]
- The reproductive system develops differently for each sex. Sex-specific parts of the male and female reproductive systems affect the rest of the body and also can be affected differently by diseases.[31]
- Socially constructed norms relate to gender roles, relationships, positional power, and a wide variety of behaviours. Norms affect people differentially depending on their sex and gender.[5]
- Different levels of prevention, reporting, diagnosis and treatment have been observed based on sex and gender.[5]
Females[6]
- 99% of breast cancer occurs in women.[32]
- Ovarian cancer, endometriosis and other diseases affect the female reproductive system.[33]
- Females are more likely to experience severe outcomes from viral respiratory tract infections during their reproductive years, compared to males of the same age. In response to treatment, females may develop greater immune responses but may also experience more adverse reactions than males.[34][35]
- Approximately four times more women suffer from osteoporosis than men.[36]
- Autoimmune diseases, such as Sjögren's syndrome and scleroderma, are more prevalent in women. Roughly 70% of those living with autoimmune diseases are female.[9][10] See Sex differences in autoimmunity.
- While estimates vary widely,[37][38] eating disorders are estimated to affect as high as 13% of women in some age groups[39][40][41] and 3% of men in Western cultures, with anorexia nervosa affecting 10 women for each man and bulimia nervosa affecting 8 women for each man.[42][43]
- Alzheimer's disease has a higher rate in women than in men.[44][45][46]
- About two times more women than men suffer from unipolar clinical depression (although bipolar disorder appears to affect both sexes equally).[47][48]
- About three times more women than men are diagnosed with borderline or histrionic personality disorder.[49]
- Conditions such as chronic fatigue syndrome (CFS)/myalgic encephalomyelitis (ME), postural orthostatic tachycardia syndrome (POTS), fibromyalgia, irritable bowel syndrome (IBS) and idiopathic hypersomnia, which have unclear causes, are more common in women, with sex ratios ranging from 2:1 in IBS,[50] fibromyalgia[51] and idiopathic hypersomnia[52] to 4:1 in CFS[53] and 5:1 in POTS.[54]
- Most people with psychogenic non-epileptic seizures (PNES) (75%) are female.[55][56][57]
- Ataxic cerebral palsy is more common in women and girls.[58]
Males[6]
- Prostate cancer, testicular cancer and other diseases of the male reproductive system occur in men.[59]
- Diseases of X-linked recessive inheritance, such as colour blindness, occur more frequently in men, and haemophilia A and B occur almost exclusively in men.[60]
- The presence of a single X chromosome in males (rather than two in females) may explain why males are more susceptible to genetic diseases linked to the X chromosome,[29][30][28] including hemophilia, Duchenne muscular dystrophy, and Hunter syndrome.[61]
- The neurodegenerative diseases Parkinson's disease and Lewy body dementia are more prevalent in men.[44]
- Abdominal aortic aneurysms are six times more common in men, and thus some countries have introduced screening for males at risk of suffering the condition.[62]
- Autism is approximately four times more prevalent in males than females.[63]
- Males have increased risk of dyskinetic cerebral palsy and spastic diplegia, as well as lower limb deformities.[58]
- Schizophrenia is about 1.4 times as common in males, and on average starts two years earlier and has more severe symptoms.[64]
- More than two times more men than women are affected by antisocial personality disorder and substance use disorder.[65][66]
- Several cancers, including stomach cancer (2:1),[67] oesophageal cancer (3:1),[68] liver cancer (2:1 to 4:1)[69] and oral cancer (2:1 to 3:1),[70] which have mostly lifestyle-based risk factors, are more common in men.
- Males are more likely to experience severe outcomes from viral respiratory tract infections than females, at younger and older ages.[34]
- Tuberculosis is more common in men.[71]
- In cases of preterm birth, being male is associated with higher mortality and morbidity in terms of respiratory distress, cardiovascular disorders (specifically hypotension), neurodevelopmental disorders, and immune disorders.[72]
- Although both men and women can suffer from eating disorders, men are less likely to be diagnosed and receive treatment.[42]
See also
- Andrology
- Gynaecology
- Health equity
- Men's health
- Obstetrics and gynecology
- Reproductive medicine
- Sex differences in humans
- Women's health
References
- ^ Ngo ST, Steyn FJ, McCombe PA (August 2014). "Gender differences in autoimmune disease". Frontiers in Neuroendocrinology. 35 (3): 347–369. doi:10.1016/j.yfrne.2014.04.004. PMID 24793874.
- ^ Barochiner J, Aparicio LS, Waisman GD (2014). "Challenges associated with peripheral arterial disease in women". Vascular Health and Risk Management. 10: 115–128. doi:10.2147/vhrm.s45181. PMC 3956880. PMID 24648743.
{{cite journal}}: CS1 maint: unflagged free DOI (link) - ^ a b c Oertelt-Prigione S, Regitz-Zagrosek V, eds. (2012). Sex and Gender Aspects in Clinical Medicine. London, UK: Springer Science & Business Media. ISBN 978-1-4471-6002-1.
{{cite book}}: CS1 maint: extra punctuation (link) - ^ a b Institute of Medicine (US) Committee on Understanding the Biology of Sex and Gender Differences. (2001). Wizemann TM, Pardue ML (eds.). Exploring the Biological Contributions to Human Health: Does Sex Matter?. Washington (DC): National Academies Press (. ISBN 978-0-309-07281-6. PMID 25057540.
- ^ a b c d e f g Mauvais-Jarvis F, Bairey Merz N, Barnes PJ, Brinton RD, Carrero JJ, DeMeo DL, et al. (August 2020). "Sex and gender: modifiers of health, disease, and medicine". Lancet. 396 (10250): 565–582. doi:10.1016/S0140-6736(20)31561-0. PMC 7440877. PMID 32828189.
- ^ a b c d Regitz-Zagrosek V (June 2012). "Sex and gender differences in health. Science & Society Series on Sex and Science". EMBO Reports. 13 (7): 596–603. doi:10.1038/embor.2012.87. PMC 3388783. PMID 22699937.
- ^ Miller VM (May 2020). "Universality of sex differences in cardiovascular outcomes: where do we go from here?". European Heart Journal. 41 (17): 1697–1699. doi:10.1093/eurheartj/ehaa310. PMC 7194182. PMID 32357237.
- ^ Weatherald J, Riha RL, Humbert M (December 2021). "Sex and gender in lung health and disease: more than just Xs and Ys". European Respiratory Review. 30 (162): 210217. doi:10.1183/16000617.0217-2021. PMID 34750117. S2CID 243861859.
- ^ a b Rose NR, Bona C (September 1993). "Defining criteria for autoimmune diseases (Witebsky's postulates revisited)". Immunology Today. 14 (9): 426–430. doi:10.1016/0167-5699(93)90244-F. PMID 8216719.
- ^ a b Hayter SM, Cook MC (August 2012). "Updated assessment of the prevalence, spectrum and case definition of autoimmune disease". Autoimmunity Reviews. 11 (10): 754–765. doi:10.1016/j.autrev.2012.02.001. PMID 22387972.
- ^ Greuter T, Manser C, Pittet V, Vavricka SR, Biedermann L (2020). "Gender Differences in Inflammatory Bowel Disease". Digestion. 101 (1): 98–104. doi:10.1159/000504701. PMID 31995797. S2CID 210946741.
- ^ van Kessel L, Teunissen D, Lagro-Janssen T (March 2021). "Sex-Gender Differences in the Effectiveness of Treatment of Irritable Bowel Syndrome: A Systematic Review". International Journal of General Medicine. 14: 867–884. doi:10.2147/IJGM.S291964. PMC 7979326. PMID 33758534.
{{cite journal}}: CS1 maint: unflagged free DOI (link) - ^ Bairey Merz CN, Dember LM, Ingelfinger JR, Vinson A, Neugarten J, Sandberg KL, et al. (December 2019). "Sex and the kidneys: current understanding and research opportunities". Nature Reviews. Nephrology. 15 (12): 776–783. doi:10.1038/s41581-019-0208-6. PMC 7745509. PMID 31586165.
- ^ Bhargava A, Arnold AP, Bangasser DA, Denton KM, Gupta A, Hilliard Krause LM, et al. (May 2021). "Considering Sex as a Biological Variable in Basic and Clinical Studies: An Endocrine Society Scientific Statement". Endocrine Reviews. 42 (3): 219–258. doi:10.1210/endrev/bnaa034. PMC 8348944. PMID 33704446.
{{cite journal}}: CS1 maint: PMC embargo expired (link) - ^ Lauretta R, Sansone M, Sansone A, Romanelli F, Appetecchia M (21 October 2018). "Gender in Endocrine Diseases: Role of Sex Gonadal Hormones". International Journal of Endocrinology. 2018: 4847376. doi:10.1155/2018/4847376. PMC 6215564. PMID 30420884.
- ^ Murphy WG (March 2014). "The sex difference in haemoglobin levels in adults - mechanisms, causes, and consequences". Blood Reviews. 28 (2): 41–47. doi:10.1016/j.blre.2013.12.003. PMID 24491804.
- ^ Clayton JA (December 2016). "Sex influences in neurological disorders: case studies and perspectives". Dialogues in Clinical Neuroscience. 18 (4): 357–360. doi:10.31887/DCNS.2016.18.4/jclayton. PMC 5286721. PMID 28179807.
- ^ Institute of Medicine (2011). Sex Differences and Implications for Translational Neuroscience Research : Workshop Summary. Washington, DC: National Academies Press. ISBN 978-0-309-16124-4.
- ^ Rippon G, Eliot L, Genon S, Joel D (May 2021). "How hype and hyperbole distort the neuroscience of sex differences". PLoS Biology. 19 (5): e3001253. doi:10.1371/journal.pbio.3001253. PMC 8136838. PMID 33970901.
{{cite journal}}: CS1 maint: unflagged free DOI (link) - ^ Shansky RM, Murphy AZ (April 2021). "Considering sex as a biological variable will require a global shift in science culture". Nature Neuroscience. 24 (4): 457–464. doi:10.1038/s41593-021-00806-8. PMID 33649507. S2CID 232091204.
- ^ Zucker I, Prendergast BJ (June 2020). "Sex differences in pharmacokinetics predict adverse drug reactions in women". Biology of Sex Differences. 11 (1): 32. doi:10.1186/s13293-020-00308-5. PMC 7275616. PMID 32503637.
{{cite journal}}: CS1 maint: unflagged free DOI (link) - ^ Soldin OP, Mattison DR (2009). "Sex differences in pharmacokinetics and pharmacodynamics". Clinical Pharmacokinetics. 48 (3): 143–157. doi:10.2165/00003088-200948030-00001. PMC 3644551. PMID 19385708.
- ^ Madkan VK, Giancola AA, Sra KK, Tyring SK (March 2006). "Sex differences in the transmission, prevention, and disease manifestations of sexually transmitted diseases". Archives of Dermatology. 142 (3): 365–370. doi:10.1001/archderm.142.3.365. PMID 16549716.
- ^ Mauvais-Jarvis F, Merz BN, Barnes PJ, Brinton RD, Carrero JJ, DeMeo DL, et al. (22 August 2020). "Sex and gender: modifiers of health, disease, and medicine". The Lancet. 396 (10250): 565–582. doi:10.1016/S0140-6736(20)31561-0.
- ^ Legato, Marianne J.; Johnson, Paula A.; Manson, JoAnn E. (8 November 2016). "Consideration of Sex Differences in Medicine to Improve Health Care and Patient Outcomes". JAMA. 316 (18): 1865. doi:10.1001/jama.2016.13995.
- ^ Miller, Leah R.; Marks, Cheryl; Becker, Jill B.; Hurn, Patricia D.; Chen, Wei‐Jung; Woodruff, Teresa; McCarthy, Margaret M.; Sohrabji, Farida; Schiebinger, Londa; Wetherington, Cora Lee; Makris, Susan; Arnold, Arthur P.; Einstein, Gillian; Miller, Virginia M.; Sandberg, Kathryn; Maier, Susan; Cornelison, Terri L.; Clayton, Janine A. (January 2017). "Considering sex as a biological variable in preclinical research". The FASEB Journal. 31 (1): 29–34. doi:10.1096/fj.201600781r.
{{cite journal}}: CS1 maint: unflagged free DOI (link) - ^ Manotas, María Carolina; González, Daniel Mauricio; Céspedes, Camila; Forero, Catalina; Moreno, Adriana Patricia Rojas (2022). "Genetic and Epigenetic Control of Puberty". Sexual Development. 16 (1): 1–10. doi:10.1159/000519039. ISSN 1661-5425.
- ^ a b c Migeon BR (2014). Females are mosaics : X inactivation and sex differences in disease (Second ed.). Oxford: Oxford University Press. ISBN 978-0-19-992753-1.
- ^ a b Migeon BR (June 2007). "Why females are mosaics, X-chromosome inactivation, and sex differences in disease". Gender Medicine. 4 (2): 97–105. doi:10.1016/S1550-8579(07)80024-6. PMID 17707844.
- ^ a b Brown C (September 2007). "Patchwork women". Nature Genetics. 39 (9): 1043. doi:10.1038/ng0907-1043. S2CID 32145544.
- ^ Zimmermann KA (22 March 2018). "Reproductive System: Facts, Functions & Diseases". Live Science. Retrieved 11 November 2021.
- ^ "Male Breast Cancer Treatment". National Cancer Institute. 2014. Archived from the original on 4 July 2014. Retrieved 29 June 2014.
- ^ Reid BM, Permuth JB, Sellers TA (February 2017). "Epidemiology of ovarian cancer: a review". Cancer Biology & Medicine. 14 (1): 9–32. doi:10.20892/j.issn.2095-3941.2016.0084. PMID 28443200.
- ^ a b Ursin RL, Klein SL (September 2021). "Sex Differences in Respiratory Viral Pathogenesis and Treatments". Annual Review of Virology. 8 (1): 393–414. doi:10.1146/annurev-virology-091919-092720. PMID 34081540.
- ^ Klein SL, Flanagan KL (October 2016). "Sex differences in immune responses". Nature Reviews. Immunology. 16 (10): 626–638. doi:10.1038/nri.2016.90. PMID 27546235. S2CID 2258164.
- ^ Alswat KA (May 2017). "Gender Disparities in Osteoporosis". Journal of Clinical Medicine Research. 9 (5): 382–387. doi:10.14740/jocmr2970w. PMC 5380170. PMID 28392857.
- ^ Sweeting H, Walker L, MacLean A, Patterson C, Räisänen U, Hunt K (2015). "Prevalence of eating disorders in males: a review of rates reported in academic research and UK mass media". International Journal of Men's Health. 14 (2): 10.3149/jmh.1402.86. doi:10.3149/jmh.1402.86. PMC 4538851. PMID 26290657.
{{cite journal}}:|access-date=requires|url=(help) - ^ "Eating Disorder Statistics". National Eating Disorders Association. 22 August 2019. Retrieved 23 December 2021.
- ^ Stice E, Marti CN, Rohde P (May 2013). "Prevalence, incidence, impairment, and course of the proposed DSM-5 eating disorder diagnoses in an 8-year prospective community study of young women". Journal of Abnormal Psychology. 122 (2): 445–457. doi:10.1037/a0030679. PMID 23148784.
- ^ Gagne DA, Von Holle A, Brownley KA, Runfola CD, Hofmeier S, Branch KE, Bulik CM (November 2012). "Eating disorder symptoms and weight and shape concerns in a large web-based convenience sample of women ages 50 and above: results of the Gender and Body Image (GABI) study". The International Journal of Eating Disorders. 45 (7): 832–844. doi:10.1002/eat.22030. PMID 22729743.
- ^ Schaumberg K, Welch E, Breithaupt L, Hübel C, Baker JH, Munn-Chernoff MA, et al. (November 2017). "The Science Behind the Academy for Eating Disorders' Nine Truths About Eating Disorders". European Eating Disorders Review. 25 (6): 432–450. doi:10.1002/erv.2553. PMC 5711426. PMID 28967161.
{{cite journal}}:|access-date=requires|url=(help) - ^ a b Powell K (16 December 2021). "Searching for a better treatment for eating disorders". Knowable Magazine. doi:10.1146/knowable-121621-1. Retrieved 22 December 2021.
- ^ American Psychiatric Association (2013). Diagnostic and Statistical Manual of Mental Disorders (Fifth ed.). Arlington, VA: American Psychiatric Publishing. pp. 338–349. ISBN 978-0-89042-555-8.
- ^ a b Zielonka D, Stawinska-Witoszynska B (2020). "Gender Differences in Non-sex Linked Disorders: Insights From Huntington's Disease". Frontiers in Neurology. 11: 571. doi:10.3389/fneur.2020.00571. PMC 7358529. PMID 32733356.
- ^ Di Carlo A, Baldereschi M, Amaducci L, Lepore V, Bracco L, Maggi S, et al. (January 2002). "Incidence of dementia, Alzheimer's disease, and vascular dementia in Italy. The ILSA Study". Journal of the American Geriatrics Society. 50 (1): 41–48. doi:10.1046/j.1532-5415.2002.50006.x. PMID 12028245. S2CID 22576935.
- ^ Andersen K, Launer LJ, Dewey ME, Letenneur L, Ott A, Copeland JR, et al. (December 1999). "Gender differences in the incidence of AD and vascular dementia: The EURODEM Studies. EURODEM Incidence Research Group". Neurology. 53 (9): 1992–1997. doi:10.1212/wnl.53.9.1992. PMID 10599770. S2CID 22725252.
- ^ American Psychiatric Association (2013), Diagnostic and Statistical Manual of Mental Disorders (5th ed.), Arlington: American Psychiatric Publishing, pp. 160–68, ISBN 978-0-89042-555-8, retrieved 22 July 2016
- ^ Schmitt A, Malchow B, Hasan A, Falkai P (February 2014). "The impact of environmental factors in severe psychiatric disorders". Frontiers in Neuroscience. 8 (19): 19. doi:10.3389/fnins.2014.00019. PMC 3920481. PMID 24574956.
- ^ Diagnostic and statistical manual of mental disorders: DSM-5 (5th ed.). Washington [etc.]: American Psychiatric Publishing. 2013. pp. 645, 663–6. ISBN 978-0-89042-555-8.
- ^ "Definition & Facts for Irritable Bowel Syndrome | NIDDK". National Institute of Diabetes and Digestive and Kidney Diseases. Retrieved 2019-07-04.
- ^ Clauw DJ (April 2014). "Fibromyalgia: a clinical review". JAMA. 311 (15): 1547–1555. doi:10.1001/jama.2014.3266. PMID 24737367.
- ^ Mallampalli MP, Carter CL (July 2014). "Exploring sex and gender differences in sleep health: a Society for Women's Health Research Report". Journal of Women's Health. 23 (7): 553–562. doi:10.1089/jwh.2014.4816. PMC 4089020. PMID 24956068.
- ^ "Chronic fatigue syndrome". womenshealth.gov. 21 February 2017. Retrieved 13 May 2019.
- ^ Benarroch EE (December 2012). "Postural tachycardia syndrome: a heterogeneous and multifactorial disorder". Mayo Clinic Proceedings. 87 (12): 1214–1225. doi:10.1016/j.mayocp.2012.08.013. PMC 3547546. PMID 23122672.
- ^ Dworetzky, Barbara A.; Baslet, Gaston (December 2017). "Psychogenic Nonepileptic Seizures in Women". Seminars in Neurology. 37 (6): 624–631. doi:10.1055/s-0037-1607971. ISSN 1098-9021.
- ^ Türe, H. Sabiha; Tatlidil, Işıl; Kiliçarslan, Esin; Akhan, Galip (September 2019). "Gender-Related Differences in Semiology of Psychogenic Non-Epileptic Seizures". Archives of Neuropsychiatry. 56 (3): 178. doi:10.29399/npa.23420. Retrieved 23 December 2021.
- ^ Asadi-Pooya, Ali A.; Homayoun, Maryam (1 February 2020). "Psychogenic nonepileptic seizures: The sex ratio trajectory across the lifespan". Seizure. 75: 63–65. doi:10.1016/j.seizure.2019.12.017. ISSN 1059-1311. Retrieved 23 December 2021.
- ^ a b Romeo DM, Sini F, Brogna C, Albamonte E, Ricci D, Mercuri E (August 2016). "Sex differences in cerebral palsy on neuromotor outcome: a critical review". Developmental Medicine and Child Neurology. 58 (8): 809–813. doi:10.1111/dmcn.13137. PMID 27098195.
- ^ "Prostate vs. testicular cancer: Similarities and differences". Medical News Today. 25 October 2021. Retrieved 10 November 2021.
- ^ "U.S. National Library of Medicine". Archived from the original on 12 October 2007. Retrieved 2 December 2007.
- ^ Doblhammer D, Gumà J (February 12, 2018). A Demographic Perspective on Gender, Family and Health in Europe. Springer. p. 78. ISBN 978-1-01-326907-3. Retrieved 11 November 2021.
- ^ "Men to get aneurysm screening". BBC. 5 January 2008. Retrieved 6 June 2016.
- ^ Newschaffer CJ, Croen LA, Daniels J, Giarelli E, Grether JK, Levy SE, et al. (2007). "The epidemiology of autism spectrum disorders". Annual Review of Public Health. 28: 235–258. doi:10.1146/annurev.publhealth.28.021406.144007. PMID 17367287.
- ^ Picchioni MM, Murray RM (July 2007). "Schizophrenia". BMJ. 335 (7610): 91–95. doi:10.1136/bmj.39227.616447.BE. PMC 1914490. PMID 17626963.
- ^ Alegria AA, Blanco C, Petry NM, Skodol AE, Liu SM, Grant B, Hasin D (July 2013). "Sex differences in antisocial personality disorder: results from the National Epidemiological Survey on Alcohol and Related Conditions". Personality Disorders. 4 (3): 214–222. doi:10.1037/a0031681. PMC 3767421. PMID 23544428.
- ^ Galanter M, Kleber HD, Brady KT, eds. (17 December 2014). The American Psychiatric Publishing Textbook of Substance Abuse Treatment. doi:10.1176/appi.books.9781615370030. ISBN 978-1-58562-472-0.
- ^ World Cancer Report 2014. World Health Organization. 2014. pp. Chapter 5.4. ISBN 978-9283204299.
- ^ Montgomery EA (2014). "Oesophageal Cancer". In Stewart BW, Wild CP (eds.). World Cancer Report 2014. World Health Organization. pp. 528–543. ISBN 978-9283204299.
- ^ Hefaiedh R, Ennaifer R, Romdhane H, Ben Nejma H, Arfa N, Belhadj N, et al. (Aug–Sep 2013). "Gender difference in patients with hepatocellular carcinoma". La Tunisie Medicale. 91 (8–9): 505–508. PMID 24227507.
- ^ Chaturvedi AK, Anderson WF, Lortet-Tieulent J, Curado MP, Ferlay J, Franceschi S, et al. (December 2013). "Worldwide trends in incidence rates for oral cavity and oropharyngeal cancers". Journal of Clinical Oncology. 31 (36): 4550–4559. doi:10.1200/jco.2013.50.3870. PMC 3865341. PMID 24248688.
- ^ Hertz D, Schneider B (March 2019). "Sex differences in tuberculosis". Seminars in Immunopathology. 41 (2): 225–237. doi:10.1007/s00281-018-0725-6. PMID 30361803. S2CID 53030554.
- ^ O'Driscoll DN, McGovern M, Greene CM, Molloy EJ (May 2018). "Gender disparities in preterm neonatal outcomes". Acta Paediatrica. 107 (9): 1494–1499. doi:10.1111/apa.14390. PMID 29750838. S2CID 21676905.