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  • Thumbnail for Cannabinoid receptor 2
    The cannabinoid receptor 2 (CB2), is a G protein-coupled receptor from the cannabinoid receptor family that in humans is encoded by the CNR2 gene. It...
    36 KB (3,879 words) - 07:03, 23 December 2023
  • for the cannabinoid receptor type 1 (CB1) or cannabinoid receptor type 2 (CB2). Manera C, Tuccinardi T, Martinelli A (2008). "Indoles and related compounds...
    50 KB (883 words) - 15:26, 19 July 2023
  • Thumbnail for AM-1221
    AM-1221 (category CB2 receptor agonists)
    cannabinoid receptor CB2, with a Ki of 0.28 nM at CB2 and 52.3 nM at the CB1 receptor, giving it around 180 times selectivity for CB2. The 2-methyl and 6-nitro...
    4 KB (258 words) - 21:42, 8 February 2024
  • Thumbnail for Cannabinoid receptor
    and CB2. The CB1 receptor is expressed mainly in the brain (central nervous system or "CNS"), but also in the lungs, liver and kidneys. The CB2 receptor...
    32 KB (3,086 words) - 01:45, 9 May 2024
  • Thumbnail for JWH-098
    JWH-098 (category CB2 receptor agonists)
    markedly different affinity for the CB1 and CB2 receptors. While JWH-081 is around tenfold selective for CB1 over CB2, in JWH-098 this is reversed, and it is...
    5 KB (355 words) - 08:04, 13 October 2023
  • Thumbnail for Onternabez
    Onternabez (category CB2 receptor agonists)
    for the cannabinoid-2 receptor (CB2 receptor) subtype, with a selectivity more than 5,000 times greater for the CB2 receptor than the CB1 receptor. The...
    5 KB (297 words) - 20:09, 18 April 2024
  • Thumbnail for JWH-051
    for CB2, with a Ki value of 14nM at CB2 vs 19nM at CB1. It was one of the first CB2-selective ligands developed, although its selectivity for CB2 is modest...
    4 KB (303 words) - 20:33, 19 July 2022
  • Thumbnail for JWH-133
    JWH-133 (category CB2 receptor agonists)
    is a potent selective CB2 receptor agonist with a Ki of 3.4nM and selectivity of around 200x for CB2 over CB1 receptors. It was discovered...
    7 KB (579 words) - 13:22, 26 November 2023
  • Thumbnail for JWH-015
    JWH-015 (category CB2 receptor agonists)
    affinity for CB2 receptors is 13.8 nM, while its affinity for CB1 is 383 nM, meaning that it binds almost 28 times more strongly to CB2 than to CB1. However...
    8 KB (738 words) - 11:15, 26 November 2023
  • Thumbnail for AM-1241
    potent and selective agonist for the cannabinoid receptor CB2, with a Ki of 3.4 nM at CB2 and 80 times selectivity over the related CB1 receptor. It...
    8 KB (696 words) - 22:21, 7 January 2024
  • Huffman, J. W. (2008). "Targeting the cannabinoid CB2 receptor: modelling and structural determinants of CB2 selective ligands". British Journal of Pharmacology...
    19 KB (996 words) - 01:51, 5 March 2024
  • Thumbnail for AM-630
    receptor CB2, with a Ki of 32.1 nM at CB2 and 165x selectivity over CB1, at which it acted as a weak partial agonist. It is used in the study of CB2 mediated...
    7 KB (472 words) - 21:40, 8 February 2024
  • Thumbnail for JWH-398
    JWH-398 (category CB2 receptor agonists)
    cannabinoid agonist at both the CB1 and CB2 receptors. It has mild selectivity for CB1 with a Ki of 2.3 nM and 2.8 nM at CB2. This synthetic chemical compound...
    4 KB (227 words) - 14:20, 24 March 2024
  • Thumbnail for JWH-019
    JWH-019 (category CB2 receptor agonists)
    naphthoylindole family that acts as a cannabinoid agonist at both the CB1 and CB2 receptors. It is the N-hexyl homolog of the more common synthetic cannabinoid...
    5 KB (414 words) - 11:20, 16 February 2023
  • Thumbnail for Cannabinol
    Cannabinol (category CB2 receptor agonists)
    acts as a low affinity partial agonist at both CB1 and CB2 receptors. This activity at CB1 and CB2 receptors constitutes interaction of CBN with the endocannabinoid...
    28 KB (2,138 words) - 07:52, 1 May 2024
  • Thumbnail for AM-2389
    CB1 receptor, with a Ki of 0.16 nM, and 26× selectivity over the related CB2 receptor. It has high potency in animal tests of cannabinoid activity, and...
    4 KB (292 words) - 01:08, 28 December 2023
  • Thumbnail for JWH-359
    selective CB2 receptor agonist, with a Ki of 13.0 nM and selectivity of around 220 times for CB2 over CB1 receptors. It is related to other dibenzopyran CB2 agonists...
    2 KB (165 words) - 20:09, 21 July 2022
  • Thumbnail for JWH-007
    JWH-007 (category CB2 receptor agonists)
    naphthoylindole family, which acts as a cannabinoid agonist at both the CB1 and CB2 receptors. It was first reported in 1994 by a group including the noted cannabinoid...
    7 KB (640 words) - 04:44, 26 December 2023
  • Thumbnail for JWH-307
    JWH-307 (category CB2 receptor agonists)
    agonist at both the CB1 and CB2 receptors. It is somewhat selective for the CB2 subtype, with a Ki of 7.7 nM at CB1 vs 3.3 nM at CB2. It was discovered by,...
    4 KB (242 words) - 14:20, 24 March 2024
  • Thumbnail for JWH-372
    JWH-372 (category CB2 receptor agonists)
    as a potent and selective agonist of the CB2 receptor. JWH-372 binds approximately 9 times stronger to the CB2 receptor (Ki = 8.2 ± 0.2nM) than the CB1...
    4 KB (289 words) - 03:20, 11 January 2023
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