2-Aminopyridine

2-Aminopyridine
Names
	IUPAC name Pyridin-2-amine
	Other names 2-Pyridinamine; 2-Pyridylamine; α-Aminopyridine; α-Pyridylamine
Identifiers
CAS Number	504-29-0 ;
3D model (JSmol)	Interactive image; Interactive image;
ChEMBL	ChEMBL21619 ;
ChemSpider	10008 ;
ECHA InfoCard	100.007.263
PubChem CID	10439;
CompTox Dashboard (EPA)	DTXSID0024505 ;
	InChI InChI=1S/C5H6N2/c6-5-3-1-2-4-7-5/h1-4H,(H2,6,7) Key: ICSNLGPSRYBMBD-UHFFFAOYSA-N ; InChI=1/C5H6N2/c6-5-3-1-2-4-7-5/h1-4H,(H2,6,7) Key: ICSNLGPSRYBMBD-UHFFFAOYAM;
	SMILES n1ccccc1N; c1ccnc(c1)N;
Properties
Chemical formula	C5H6N2
Molar mass	94.117 g·mol−1
Appearance	colourless solid
Melting point	59 to 60 °C (138 to 140 °F; 332 to 333 K)
Boiling point	210 °C (410 °F; 483 K)
Solubility in water	>100%
Hazards
Flash point	68 °C; 154 °F; 341 K
	Lethal dose or concentration (LD, LC):
LD50 (median dose)	200 mg/kg (rat, oral); 50 mg/kg (mouse, oral)
	NIOSH (US health exposure limits):
PEL (Permissible)	TWA 0.5 ppm (2 mg/m3)
REL (Recommended)	TWA 0.5 ppm (2 mg/m3)
IDLH (Immediate danger)	5 ppm
	Except where otherwise noted, data are given for materials in their standard state (at 25 °C [77 °F], 100 kPa). verify (what is ?) Infobox references

2-Aminopyridine is an organic compound with the formula H₂NC₅H₄N. It is one of three isomeric aminopyridines. It is a colourless solid that is used in the production of the drugs piroxicam, sulfapyridine, tenoxicam, and tripelennamine. It is produced by the reaction of sodium amide with pyridine, the Chichibabin reaction.^[3]

Structure

Although 2-hydroxypyridine exists in significant amounts as the pyridone tautomer, the related imine tautomer (HNC₅H₄NH) is less important for 2-aminopyridine.

References

^ ^a ^b ^c ^d ^e ^f NIOSH Pocket Guide to Chemical Hazards. "#0026". National Institute for Occupational Safety and Health (NIOSH).
^ "2-Aminopyridine". Immediately Dangerous to Life or Health Concentrations (IDLH). National Institute for Occupational Safety and Health (NIOSH).
^ "Pyridine and Pyridine Derivatives". Ullmann's Encyclopedia of Industrial Chemistry. Weinheim: Wiley-VCH. 2000. doi:10.1002/14356007.a22_399. {{cite encyclopedia}}: Cite uses deprecated parameter |authors= (help)

External links

[NIOSH-1] ^ ^a ^b ^c ^d ^e ^f NIOSH Pocket Guide to Chemical Hazards. "#0026". National Institute for Occupational Safety and Health (NIOSH).

[2] "2-Aminopyridine". Immediately Dangerous to Life or Health Concentrations (IDLH). National Institute for Occupational Safety and Health (NIOSH).

[3] "Pyridine and Pyridine Derivatives". Ullmann's Encyclopedia of Industrial Chemistry. Weinheim: Wiley-VCH. 2000. doi:10.1002/14356007.a22_399. {{cite encyclopedia}}: Cite uses deprecated parameter |authors= (help)

[1]

[2]

[3]