Amyl methyl ketone
Methyl n-amyl ketone
Methyl pentyl ketone
3D model (JSmol)
|Molar mass||114.18 g/mol|
|Melting point||−35.5 °C (−31.9 °F; 237.7 K)|
|Boiling point||151 °C (304 °F; 424 K)|
|0.4% by wt|
|Vapor pressure||3 mmHg (20°C)|
|Flash point||39 °C (102 °F; 312 K)|
|393 °C (739 °F; 666 K)|
|Explosive limits||1.1% at 151 °F (66 °C) - 7.9% at 250 °F (121 °C)|
|Lethal dose or concentration (LD, LC):|
LD50 (median dose)
|1670 mg/kg (rat, oral)|
750 mg/kg (mouse, oral)
LCLo (lowest published)
|4000 ppm (rat, 4 hr)|
2000 ppm (guinea pig, 14.8 hr)
|US health exposure limits (NIOSH):|
|TWA 100 ppm (465 mg/m3)|
|TWA 100 ppm (465 mg/m3)|
IDLH (Immediate danger)
Except where otherwise noted, data are given for materials in their standard state (at 25 °C [77 °F], 100 kPa).
|what is ‹See TfM› ?)(|
2-Heptanone is listed by the FDA as a "food additive permitted for direct addition to food for human consumption" (21 CFR 172.515), and it occurs naturally in certain foods (e.g., beer, white bread, butter, various cheeses and potato chips).
2-Heptanone has also been found to be excreted by honey bees when they bite small pests within the colony such as wax moth larvae and Varroa mites. Though it was historically believed to be an alarm pheromone, 2-heptanone has been shown to act as an anaesthetic on the pests, enabling the honey bee to stun the pest and eject it from the hive. The work could lead to the use of 2-heptanone as an alternative local anaesthetic to lidocaine, which although well established for clinical use, has the disadvantage of provoking allergic reactions in some people.
- Methyl n-amyl ketone, International Occupational Safety and Health Information Centre (CIS)
- "NIOSH Pocket Guide to Chemical Hazards #0399". National Institute for Occupational Safety and Health (NIOSH).
- "Methyl (n-amyl) ketone". Immediately Dangerous to Life and Health Concentrations (IDLH). National Institute for Occupational Safety and Health (NIOSH).
- Methyl (n-amyl) ketone, Chemical Sampling Information, Occupational Safety & Health Administration
- Wang, Z.; Balet Sindreu, C.; Li, V.; Nudelman, A.; Chan, G.C. & Storm, D.R. (2006). "Pheromonal detection in male mice depends on signaling through the type 3 adenylyl cyclase in the main olfactory epithelium". J. Neurosci. 26 (28): 7375–7379. doi:10.1523/JNEUROSCI.1967-06.2006. PMID 16837584.
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- "Honey-bees found to have bite that stuns". BBC News. 26 October 2012. Retrieved Jan 8, 2013.
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