23S rRNA pseudouridine1911/1915/1917 synthase
| 23S rRNA pseudouridine1911/1915/1917 synthase | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Identifiers | |||||||||
| EC no. | 5.4.99.23 | ||||||||
| Databases | |||||||||
| IntEnz | IntEnz view | ||||||||
| BRENDA | BRENDA entry | ||||||||
| ExPASy | NiceZyme view | ||||||||
| KEGG | KEGG entry | ||||||||
| MetaCyc | metabolic pathway | ||||||||
| PRIAM | profile | ||||||||
| PDB structures | RCSB PDB PDBe PDBsum | ||||||||
| |||||||||
23S rRNA pseudouridine1911/1915/1917 synthase (EC 5.4.99.23, RluD, pseudouridine synthase RluD) is an enzyme with systematic name 23S rRNA-uridine1911/1915/1917 uracil mutase.[1][2][3][4] This enzyme catalyses the following chemical reaction
- 23S rRNA uridine1911/uridine1915/uridine1917 23S rRNA pseudouridine1911/pseudouridine1915/pseudouridine1917
These nucleotides are located in the functionally important helix-loop 69 of 23S rRNA.
References
- ^ Leppik, M.; Peil, L.; Kipper, K.; Liiv, A.; Remme, J. (2007). "Substrate specificity of the pseudouridine synthase RluD in Escherichia coli". FEBS J. 274: 5759–5766. doi:10.1111/j.1742-4658.2007.06101.x. PMID 17937767.
- ^ Ejby, M.; Sorensen, M.A.; Pedersen, S. (2007). "Pseudouridylation of helix 69 of 23S rRNA is necessary for an effective translation termination". Proc. Natl. Acad. Sci. USA. 104: 19410–19415. doi:10.1073/pnas.0706558104. PMC 2148303. PMID 18032607.
- ^ Sivaraman, J.; Iannuzzi, P.; Cygler, M.; Matte, A. (2004). "Crystal structure of the RluD pseudouridine synthase catalytic module, an enzyme that modifies 23S rRNA and is essential for normal cell growth of Escherichia coli". J. Mol. Biol. 335: 87–101. doi:10.1016/j.jmb.2003.10.003. PMID 14659742.
- ^ Wrzesinski, J.; Bakin, A.; Ofengand, J.; Lane, B.G. (2000). "Isolation and properties of Escherichia coli 23S-RNA pseudouridine 1911, 1915, 1917 synthase (RluD)". IUBMB Life. 50: 33–37. doi:10.1080/15216540050176566. PMID 11087118.
External links
- 23S+rRNA+pseudouridine1911/1915/1917+synthase at the U.S. National Library of Medicine Medical Subject Headings (MeSH)
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