34βE12
34βE12, often written as 34betaE12 and also known as CK34βE12 and keratin 903 (CK903), is an antibody specific for high molecular weight cytokeratins 1, 5, 10 and 14.[1][2]
It is sometimes, less precisely, referred to as high-molecular weight keratin (HMWK) and high-molecular weight cytokeratin (HMWCK).
Utility
It is used to stain basal cells in prostatic glands; loss of basal cells is seen in prostate adenocarcinoma (the most common form of prostate cancer).
It can be used to differentiate in situ cancers of the breast; lobular carcinoma in situ (LCIS) exhibits perinuclear staining with 34βE12. Ductal carcinoma in situ (DCIS) does not stain for 34βE12.[2]
See also
References
- ^ Aishima S, Asayama Y, Taguchi K; et al. (November 2002). "The utility of keratin 903 as a new prognostic marker in mass-forming-type intrahepatic cholangiocarcinoma". Mod. Pathol. 15 (11): 1181–90. doi:10.1097/01.MP.0000032537.82380.69. PMID 12429797.
{{cite journal}}: CS1 maint: multiple names: authors list (link) - ^ a b Yeh IT, Mies C (March 2008). "Application of immunohistochemistry to breast lesions". Arch. Pathol. Lab. Med. 132 (3): 349–58. doi:10.1043/1543-2165(2008)132[349:AOITBL]2.0.CO;2. PMID 18318578.