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4T1 is a breast cancer cell line derived from the mammary gland tissue of a mouse.[1] 4T1 cells are epithelial and are resistant to 6-thioguanine.[citation needed] In preclinical research, 4T1 cells have been used to study breast cancer metastasis.[2] The cells are known to be highly aggressive in live tissues.[3]


  1. ^ Pulaski, BA; Ostrand-Rosenberg, S (May 2001). "Mouse 4T1 breast tumor model". Current Protocols in Immunology. 20 (20). doi:10.1002/0471142735.im2002s39. PMID 18432775.
  2. ^ Shengyu, Yang; et al. (2012). "Mouse Models for Tumor Metastasis". Methods in Molecular Biology. 928: 221–228. doi:10.1007/978-1-62703-008-3_17. PMC 3674868.
  3. ^ Disch, Bryan; et al. (30 May 2014). "Development and Characterization of a Preclinical Model of Breast Cancer Lung Micrometastatic to Macrometastatic Progression". PLoS ONE. 9 (5). doi:10.1371/journal.pone.0098624.

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