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6C RNA secondary structure sequence conservation.jpg
Symbol 6C
Rfam RF01066
Other data
RNA type Cis-reg
Domain(s) Bacteria
SO 0005836

6C RNA is a class of non-coding RNA present in actinomycetes. 6C RNA was originally discovered as a conserved RNA structure having two stem-loops each containing six or more cytosine (C) residues.[1] Later work revealed that 6C RNAs in Streptomyces coelicolor and Streptomyces avermitilis have predicted rho-independent transcription terminators, and microarray and reverse-transcriptase PCR experiments indicate that the S. coelicolor version is transcribed as RNA.[2][3] Transcription of the S. coelicolor RNA increases during sporulation, and three transcripts were detected that overlap the 6C motif, but have different apparent start and stop sites.[3]


  1. ^ Weinberg Z, Barrick JE, Yao Z, et al. (2007). "Identification of 22 candidate structured RNAs in bacteria using the CMfinder comparative genomics pipeline". Nucleic Acids Res. 35 (14): 4809–19. doi:10.1093/nar/gkm487. PMC 1950547Freely accessible. PMID 17621584. 
  2. ^ Pánek J, Bobek J, Mikulík K, Basler M, Vohradský J (2008). "Biocomputational prediction of small non-coding RNAs in Streptomyces". BMC Genomics. 9: 217. doi:10.1186/1471-2164-9-217. PMC 2422843Freely accessible. PMID 18477385. 
  3. ^ a b Swiercz JP, Hindra; Bobek J; et al. (November 2008). "Small non-coding RNAs in Streptomyces coelicolor". Nucleic Acids Res. 36 (22): 7240–51. doi:10.1093/nar/gkn898. PMC 2602773Freely accessible. PMID 19008244. 

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