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Alison Goate

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Alison Goate
CitizenshipBritish
EducationOxford University (DPhil 1983)
Known forAlzheimer's disease, addiction
AwardsPotamkin Prize (1993)
Metlife Foundation Award (1994)
Alzheimer's Association Lifetime Achievement Award (2015)
Scientific career
FieldsNeurology, Genetics
InstitutionsIcahn School of Medicine
Washington University

Alison M. Goate is a professor of neuroscience and Director of the Loeb Center for Alzheimer's Disease at Icahn School of Medicine at Mount Sinai, New York City.[1][2] She was previously professor of genetics in psychiatry, professor of genetics, and professor of neurology at Washington University in St. Louis.[3]

The Goate Lab studies the genetics and molecular bases of Alzheimer's disease, frontotemporal dementia, and alcoholism.[4]

Education and early career

After receiving her undergraduate degree in biochemistry at the University of Bristol (UK) and her graduate training at Oxford University (UK), Goate studied under Professors Theodore Puck, Professor Louis Lim and Dr. John Hardy. She received a Royal Society University Research Fellowship to conduct research at St. Mary's Hospital Medical School in London.[5]

Awards and affiliations

She has received the Potamkin Prize from the American Academy of Neurology (1993), the Zenith Award from the Alzheimer's Association, Senior Investigator Award from the Metropolitan Life Foundation, the St Louis Academy of Science Innovation Award, Carl and Gerty Cori Faculty Achievement Award at Washington University. (1994), and a Lifetime Achievement Award from the Alzheimer's Association (2015).[6] She is a fellow of the American Association for the Advancement of Science.[1] She also serves on the faculty of the Hope Center for Neurological Disorders[7] and as an elected member of the National Academy of Medicine.[8]

Research

Goate's research centers on the genetics of Alzheimer's disease and related dementias that led to the development of animal and cellular models and the development of anti-amyloid and anti-tau therapies. She has been the principal investigator on four grants and has co-invented and granted six patents.

Patents

Patent Number Title
8,080,371[9] Markers for addiction
6,475,723[10] Pathogenic tau mutations
6,300,540[11] Transgenic mouse expressing an APP-FAD DNA sequence
6,083,694[12] Method for elucidation and detection of polymorphisms, splice variants, and alzheimer'ss S182 gene ns using intronic sequences of the alzheimer's S182 gene
5,973,133[13] Mutant S182 genes
5,877,015[14] APP770 mutant in alzheimer's disease

Grants

Partial list:[15]

Funding Source, Project Title & Number Role in Project Dates Direct Costs
JPB Foundation

Identification of Novel Alzheimer's disease genes using next generation sequencing[16]

Principal Investigator 9/1/14-8/31/20 $681,818
NIA

Identification and characterization of AD risk networks using multi-dimensional “omics” data NIA U01 AG052411[17]

Principal Investigator 7/15/16-5/31/21 $871,083
Neurodegeneration Consortium- MD Anderson

Understanding the mechanism of MS4A-dependent AD risk

Principal Investigator 08/07/17-08/06/22 $400,000
NIA

Understanding the mechanism of SPI1 dependent Alzheimer disease risk NIA RF1AG054011[18]

Principal Investigator 8/01/16-6/30/21 $498,389

Publications

Semantic Scholar lists 483 publications, 22,943 citations and 1,808 influential citations of Goate's peer-reviewed and original contribution as of 2019.[19]

Partial list:

  • Goate, A.; et al. (1991). "Segregation of a missense mutation in the amyloid precursor protein gene with familial Alzheimer's disease". Nature. 349 (6311): 704–706. Bibcode:1991Natur.349..704G. doi:10.1038/349704a0. PMID 1671712. S2CID 4336069. Cited by 5017 as of October 18, 2019.[20]
  • De Strooper, B.; et al. (1999). "A presenilin-1-dependent gamma-secretase-like protease mediates release of Notch intracellular domain". Nature. 398 (6727): 518–22. Bibcode:1999Natur.398..518D. doi:10.1038/19083. PMID 10206645. S2CID 4346474. Cited by 2274 as of October 18, 2019.[20]
  • Saccone, S. F.; et al. (2007). "Cholinergic nicotinic receptor genes implicated in a nicotine dependence association study targeting 348 candidate genes with 3713 SNPS". Human Molecular Genetics. 16 (1): 36–49. doi:10.1093/hmg/ddl438. PMC 2270437. PMID 17135278. Cited by 793 as of October 18, 2019[20]
  • Bierut, L. J.; et al. (2007). "Novel genes identified in a high-density genome wide association study for nicotine dependence". Human Molecular Genetics. 16 (1): 24–35. doi:10.1093/hmg/ddl441. PMC 2278047. PMID 17158188. Cited by 604 as of October 18, 2019.[20]
  • Kehoe, P.; et al. (1999). "A full genome scan for late onset Alzheimer's disease". Human Molecular Genetics. 8 (2): 237–45. doi:10.1093/hmg/8.2.237. PMID 9931331. Cited by 419 as of October 18, 2019[20]
  • Foroud, T.; et al. (2000). "Alcoholism susceptibility loci: Confirmation studies in a replicate sample and further mapping". Alcoholism, Clinical and Experimental Research. 24 (7): 933–45. doi:10.1111/j.1530-0277.2000.tb04634.x. PMID 10923994. Cited by 275 as of October 18, 2019.[20]

References

  1. ^ a b "Alison M Goate". Icahn School of Medicine at Mount Sinai. Retrieved 23 October 2018.
  2. ^ "Huffington Center on Aging celebrates 30th anniversary". BCM Family. 2018-11-05. Retrieved 2019-10-18.
  3. ^ Goate, Alison (2008). "Interview". Biomarkers in Medicine. 2 (6). Future Medicine Ltd: 541–545. doi:10.2217/17520363.2.6.541. ISSN 1752-0363. PMID 20477443.
  4. ^ Icahn School of Medicine at Mount Sinai. "Goate Lab". Icahn School of Medicine at Mount Sinai. Retrieved 26 August 2019.
  5. ^ Goate, Alison (December 2008). "Interview". Biomarkers in Medicine. 2 (6): 541–545. doi:10.2217/17520363.2.6.541. PMID 20477443. Retrieved 19 October 2019.
  6. ^ Goate, Alison (2 December 2008). "Interview with Alison Goate". Biomarkers in Medicine. 2 (6): 541–545. doi:10.2217/17520363.2.6.541. ISSN 1752-0371. PMID 20477443.
  7. ^ "Announcements: Bob Lane Receives Lifetime Achievement Award". 1998. doi:10.1037/e404572005-032. {{cite journal}}: Cite journal requires |journal= (help)
  8. ^ "National Academy of Medicine Elects 80 New Members". National Academy of Medicine. October 17, 2016. Retrieved October 18, 2019.{{cite web}}: CS1 maint: url-status (link)
  9. ^ 8080371, Ballinger, Dennis; Konvicka, Karel & Bierut, Laura Jean et al., "United States Patent: 8080371 - Markers for addiction", issued December 20, 2011 
  10. ^ 6475723, Hutton, Michael L.; Heutink, Peter & NL et al., "United States Patent: 6475723 - Pathogenic tau mutations", issued November 5, 2002 
  11. ^ 6300540, Hardy, John Anthony; Chartier-Harlin, Marie-Christine & FR et al., "United States Patent: 6300540 - Transgenic mouse expressing an APP-FAD DNA sequence", issued October 9, 2001 
  12. ^ 6083694, Hardy, John & Goate, Alison M., "United States Patent: 6083694 - Method for elucidation and detection of polymorphisms, splice variants, and proximal coding mutations using intronic sequences of the alzheimer's S182 gene", issued July 4, 2000 
  13. ^ 5973133, Hardy, John A. & Goate, Alison M., "United States Patent: 5973133 - Mutant S182 genes", issued October 26, 1999 
  14. ^ 5877015, Hardy, John Anthony; Chartier-Harlin, Marie-Christine & FR et al., "United States Patent: 5877015 - APP770 mutant in alzheimer's disease", issued March 2, 1999 
  15. ^ "Alison M. Goate, PhD - US grants". Neurotree. Retrieved September 15, 2019.{{cite web}}: CS1 maint: url-status (link)
  16. ^ "Full text of "Form 990PF" for fiscal year ending Dec. 2017". ProPublica. Retrieved 15 September 2019.
  17. ^ Bis, Joshua C.; Jian, Xueqiu; Kunkle, Brian W.; Chen, Yuning; Hamilton-Nelson, Kara L.; Bush, William S.; Salerno, William J.; Lancour, Daniel; Ma, Yiyi; Renton, Alan E.; Marcora, Edoardo; Farrell, John J.; Zhao, Yi; Qu, Liming; Ahmad, Shahzad; Amin, Najaf; Amouyel, Philippe; Beecham, Gary W.; Below, Jennifer E.; Campion, Dominique; Charbonnier, Camille; Chung, Jaeyoon; Crane, Paul K.; Cruchaga, Carlos; Cupples, L. Adrienne; Dartigues, Jean-François; Debette, Stéphanie; Deleuze, Jean-François; Fulton, Lucinda; et al. (2018). "Whole exome sequencing study identifies novel rare and common Alzheimer's-Associated variants involved in immune response and transcriptional regulation". Molecular Psychiatry. 25 (8). Broad Institute: 1859–1875. doi:10.1038/s41380-018-0112-7. PMC 6375806. PMID 30108311. Retrieved 15 September 2019.
  18. ^ Goate, Alison M.; Marcora, Edoardo; Hao, Ke; Poon, Wayne W.; Roussos, Panos; Bendl, Jaroslav; Fullard, John F.; Cheng, Haoxiang; Efthymiou, Anastasia G.; Abud, Edsel M.; Tcw, Julia; Kapoor, Manav; Novikova, Gloriia (2019-08-12). "Integration of Alzheimer's disease genetics and myeloid genomics reveals novel disease risk mechanisms". bioRxiv. Cold Spring Harbor Laboratory: 694281. doi:10.1101/694281. Retrieved 15 September 2019.
  19. ^ "Alison M. Goate - Semantic Scholar". www.semanticscholar.org. Retrieved 2019-10-18.
  20. ^ a b c d e f "Google Scholar". scholar.google.com. Retrieved 2019-10-18.
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