Darier's sign

Stroking the skin leads to a localised subcutaneous anaphylactoid reaction with mast cell degranulation and urticarial rash.

Darier's sign is a change observed after stroking lesions on the skin of a person with systemic mastocytosis or urticaria pigmentosa.

In general, the skin becomes swollen, itchy and red. This is a result of compression of mast cells, which are hyperactive in these diseases. These mast cells release inflammatory granules which contain histamine. It is the histamine which is responsible for the response seen after rubbing the lesional skin.

Eponym

Darier's sign is named after the French dermatologist Ferdinand-Jean Darier (1856–1938) who first described it.^[1]

References

^ synd/489 at Who Named It?

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[1] synd/489 at Who Named It?

[1]

v t e Signs and symptoms relating to skin and subcutaneous tissue
Disturbances of skin sensation	Hypoesthesia Paresthesia Formication Hyperesthesia Hypoalgesia Hyperalgesia
Circulation	Cyanosis Pallor Livedo Livedo reticularis Flushing Petechia Blanching
Edema	Peripheral edema Anasarca
Other	Rash Desquamation Induration Diaphoresis Mass Neck mass
Skin	Asboe-Hansen sign Auspitz's sign Borsari's sign Braverman's sign Crowe sign Dennie–Morgan fold Darier's sign Fitzpatrick's sign Florid cutaneous papillomatosis Gottron's sign Hutchinson's sign Janeway lesion Kerr's sign Koebner's phenomenon Koplik's spots Leser-Trelat sign Nikolsky's sign Pastia's sign Russell's sign Wickham striae Wolf's isotopic response Munro's microabscess
Nails	Aldrich-Mees' lines Beau's lines Muehrcke's lines Terry's nails

Eponym

See also

References