Telomere-associated protein RIF1

RIF1
Identifiers
Aliases	RIF1, replication timing regulatory factor 1
External IDs	OMIM: 608952; MGI: 1098622; HomoloGene: 41231; GeneCards: RIF1; OMA:RIF1 - orthologs
Gene location (Human)
Chr.	Chromosome 2 (human)
End	151,508,013 bp
Gene location (Mouse)
Chr.	Chromosome 2 (mouse)
End	52,012,395 bp
RNA expression pattern
	Top expressed in
	buccal mucosa cell; ; gastrocnemius muscle; ; muscle of thigh; ; Achilles tendon; ; testicle; ; secondary oocyte; ; Skeletal muscle tissue of rectus abdominis; ; corpus callosum; ; internal globus pallidus; ; gonad;
	Top expressed in
	spermatocyte; ; zygote; ; secondary oocyte; ; primary oocyte; ; primitive streak; ; cumulus cell; ; epiblast; ; Gonadal ridge; ; spermatid; ; abdominal wall;
	More reference expression data
	More reference expression data
Gene ontology
Molecular function	protein binding;
Cellular component	cytoplasm; telomere; plasma membrane; spindle; male pronucleus; female pronucleus; nucleus; cytoskeleton; nucleoplasm; chromosome; condensed chromosome; nuclear body; nuclear membrane; spindle midzone; site of double-strand break;
Biological process	stem cell population maintenance; cell cycle; double-strand break repair via nonhomologous end joining; negative regulation of transcription by RNA polymerase II; telomere maintenance; telomere maintenance in response to DNA damage; positive regulation of histone H3-K9 methylation; cellular response to DNA damage stimulus; positive regulation of isotype switching; negative regulation of double-strand break repair via homologous recombination; positive regulation of double-strand break repair via nonhomologous end joining; DNA repair; cellular response to leukemia inhibitory factor;
	Sources:Amigo / QuickGO
Orthologs
	55183
	51869
	ENSG00000080345
	ENSMUSG00000036202
	Q5UIP0
	Q6PR54
	NM_001177663; NM_001177664; NM_001177665; NM_018151
	NM_175238; NM_001355414; NM_001355415
	NP_001171134; NP_001171135; NP_001171136; NP_060621
	NP_780447; NP_001342343; NP_001342344
	Wikidata
View/Edit Human	View/Edit Mouse

Telomere-associated protein RIF1 is a protein that in humans is encoded by the RIF1 gene.^[5]^[6]^[7]

RIF1 and RIF2 cap the chromosome ends (telomeres) in yeast.^[8] In higher eukaryotes, Rif1 is involved in DNA damage response, organisation of chromatin architecture and the regulation of replication timing. RIF1 has been shown to bind to RNA in the nucleus.^[9]

References

^ ^a ^b ^c GRCh38: Ensembl release 89: ENSG00000080345 – Ensembl, May 2017
^ ^a ^b ^c GRCm38: Ensembl release 89: ENSMUSG00000036202 – Ensembl, May 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ Silverman J, Takai H, Buonomo SB, Eisenhaber F, de Lange T (September 2004). "Human Rif1, ortholog of a yeast telomeric protein, is regulated by ATM and 53BP1 and functions in the S-phase checkpoint". Genes & Development. 18 (17): 2108–19. doi:10.1101/gad.1216004. PMC 515289. PMID 15342490.
^ Adams IR, McLaren A (April 2004). "Identification and characterisation of mRif1: a mouse telomere-associated protein highly expressed in germ cells and embryo-derived pluripotent stem cells". Developmental Dynamics. 229 (4): 733–44. doi:10.1002/dvdy.10471. PMID 15042697. S2CID 22138565.
^ "Entrez Gene: RIF1 RAP1 interacting factor homolog (yeast)".
^ Ribeyre C, Shore D (2012). "Anticheckpoint pathways at telomeres in yeast". Nature Structural & Molecular Biology. 19 (3): 307–13. doi:10.1038/nsmb.2225. PMID 22343724. S2CID 10636976.
^ Conrad T, Albrecht AS, de Melo Costa VR, Sauer S, Meierhofer D, Ørom UA (2016-01-01). "Serial interactome capture of the human cell nucleus". Nature Communications. 7: 11212. Bibcode:2016NatCo...711212C. doi:10.1038/ncomms11212. PMC 4822031. PMID 27040163.

Andersson B, Wentland MA, Ricafrente JY, Liu W, Gibbs RA (April 1996). "A "double adaptor" method for improved shotgun library construction". Analytical Biochemistry. 236 (1): 107–13. doi:10.1006/abio.1996.0138. PMID 8619474.
Yu W, Andersson B, Worley KC, Muzny DM, Ding Y, Liu W, Ricafrente JY, Wentland MA, Lennon G, Gibbs RA (April 1997). "Large-scale concatenation cDNA sequencing". Genome Research. 7 (4): 353–8. doi:10.1101/gr.7.4.353. PMC 139146. PMID 9110174.
Beausoleil SA, Jedrychowski M, Schwartz D, Elias JE, Villén J, Li J, Cohn MA, Cantley LC, Gygi SP (August 2004). "Large-scale characterization of HeLa cell nuclear phosphoproteins". Proceedings of the National Academy of Sciences of the United States of America. 101 (33): 12130–5. Bibcode:2004PNAS..10112130B. doi:10.1073/pnas.0404720101. PMC 514446. PMID 15302935.
Xu L, Blackburn EH (December 2004). "Human Rif1 protein binds aberrant telomeres and aligns along anaphase midzone microtubules". The Journal of Cell Biology. 167 (5): 819–30. doi:10.1083/jcb.200408181. PMC 2172464. PMID 15583028.
Beausoleil SA, Villén J, Gerber SA, Rush J, Gygi SP (October 2006). "A probability-based approach for high-throughput protein phosphorylation analysis and site localization". Nature Biotechnology. 24 (10): 1285–92. doi:10.1038/nbt1240. PMID 16964243. S2CID 14294292.
Olsen JV, Blagoev B, Gnad F, Macek B, Kumar C, Mortensen P, Mann M (November 2006). "Global, in vivo, and site-specific phosphorylation dynamics in signaling networks". Cell. 127 (3): 635–48. doi:10.1016/j.cell.2006.09.026. PMID 17081983. S2CID 7827573.

This article on a gene on human chromosome 2 is a stub. You can help Wikipedia by expanding it.

[refGRCh38Ensembl-1] GRCh38: Ensembl release 89: ENSG00000080345 – Ensembl, May 2017

[refGRCm38Ensembl-2] GRCm38: Ensembl release 89: ENSMUSG00000036202 – Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[pmid15342490-5] Silverman J, Takai H, Buonomo SB, Eisenhaber F, de Lange T (September 2004). "Human Rif1, ortholog of a yeast telomeric protein, is regulated by ATM and 53BP1 and functions in the S-phase checkpoint". Genes & Development. 18 (17): 2108–19. doi:10.1101/gad.1216004. PMC 515289. PMID 15342490.

[pmid15042697-6] Adams IR, McLaren A (April 2004). "Identification and characterisation of mRif1: a mouse telomere-associated protein highly expressed in germ cells and embryo-derived pluripotent stem cells". Developmental Dynamics. 229 (4): 733–44. doi:10.1002/dvdy.10471. PMID 15042697. S2CID 22138565.

[entrez-7] "Entrez Gene: RIF1 RAP1 interacting factor homolog (yeast)".

[pmid22343724-8] Ribeyre C, Shore D (2012). "Anticheckpoint pathways at telomeres in yeast". Nature Structural & Molecular Biology. 19 (3): 307–13. doi:10.1038/nsmb.2225. PMID 22343724. S2CID 10636976.

[9] Conrad T, Albrecht AS, de Melo Costa VR, Sauer S, Meierhofer D, Ørom UA (2016-01-01). "Serial interactome capture of the human cell nucleus". Nature Communications. 7: 11212. Bibcode:2016NatCo...711212C. doi:10.1038/ncomms11212. PMC 4822031. PMID 27040163.

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References

Further reading