S100 calcium-binding protein A13 (S100A13) is a protein that in humans is encoded by the S100A13gene.[5][6]
Function
The protein encoded by this gene is a member of the S100 family of proteins containing 2 EF-hand calcium-binding motifs. S100 proteins are localized in the cytoplasm and/or nucleus of a wide range of cells, and involved in the regulation of a number of cellular processes such as cell cycle progression and differentiation. S100 genes include at least 13 members which are located as a cluster on chromosome 1q21. This protein is widely expressed in various types of tissues with a high expression level in thyroid gland. In smooth muscle cells, this protein co-expresses with other family members in the nucleus and in stress fibers, suggesting diverse functions in signal transduction. Multiple alternatively spliced transcript variants encoding the same protein have been found for this gene.[6]
Up-regulation of S100A13 was detected in cystic papillary thyroid carcinoma[9] and association of S100A13 expression and chemotherapy resistance was shown in proteomics study of melanoma.[10]
^"Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^"Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^Wicki R, Marenholz I, Mischke D, Schäfer BW, Heizmann CW (Dec 1996). "Characterization of the human S100A12 (calgranulin C, p6, CAAF1, CGRP) gene, a new member of the S100 gene cluster on chromosome 1q21". Cell Calcium. 20 (6): 459–64. doi:10.1016/S0143-4160(96)90087-1. PMID8985590.
Schäfer BW, Wicki R, Engelkamp D, Mattei MG, Heizmann CW (Feb 1995). "Isolation of a YAC clone covering a cluster of nine S100 genes on human chromosome 1q21: rationale for a new nomenclature of the S100 calcium-binding protein family". Genomics. 25 (3): 638–43. doi:10.1016/0888-7543(95)80005-7. PMID7759097.
Wicki R, Schäfer BW, Erne P, Heizmann CW (Oct 1996). "Characterization of the human and mouse cDNAs coding for S100A13, a new member of the S100 protein family". Biochemical and Biophysical Research Communications. 227 (2): 594–9. doi:10.1006/bbrc.1996.1551. PMID8878558.
Chan WY, Xia CL, Dong DC, Heizmann CW, Yew DT (Apr 2003). "Differential expression of S100 proteins in the developing human hippocampus and temporal cortex". Microscopy Research and Technique. 60 (6): 600–13. doi:10.1002/jemt.10302. PMID12645008. S2CID13596098.
Hsieh HL, Schäfer BW, Weigle B, Heizmann CW (Apr 2004). "S100 protein translocation in response to extracellular S100 is mediated by receptor for advanced glycation endproducts in human endothelial cells". Biochemical and Biophysical Research Communications. 316 (3): 949–59. doi:10.1016/j.bbrc.2004.02.135. PMID15033494.
Hayrabedyan S, Kyurkchiev S, Kehayov I (Mar 2005). "Endoglin (cd105) and S100A13 as markers of active angiogenesis in endometriosis". Reproductive Biology. 5 (1): 51–67. PMID15821778.
Rual JF, Venkatesan K, Hao T, Hirozane-Kishikawa T, Dricot A, Li N, Berriz GF, Gibbons FD, Dreze M, Ayivi-Guedehoussou N, Klitgord N, Simon C, Boxem M, Milstein S, Rosenberg J, Goldberg DS, Zhang LV, Wong SL, Franklin G, Li S, Albala JS, Lim J, Fraughton C, Llamosas E, Cevik S, Bex C, Lamesch P, Sikorski RS, Vandenhaute J, Zoghbi HY, Smolyar A, Bosak S, Sequerra R, Doucette-Stamm L, Cusick ME, Hill DE, Roth FP, Vidal M (Oct 2005). "Towards a proteome-scale map of the human protein-protein interaction network". Nature. 437 (7062): 1173–8. Bibcode:2005Natur.437.1173R. doi:10.1038/nature04209. PMID16189514. S2CID4427026.
Oh JH, Yang JO, Hahn Y, Kim MR, Byun SS, Jeon YJ, Kim JM, Song KS, Noh SM, Kim S, Yoo HS, Kim YS, Kim NS (Dec 2005). "Transcriptome analysis of human gastric cancer". Mammalian Genome. 16 (12): 942–54. doi:10.1007/s00335-005-0075-2. PMID16341674. S2CID69278.
