ANKRD27

ANKRD27
Available structures
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	4B93, 4CYM, 4CZ2
Identifiers
Aliases	ANKRD27, VARP, PP12899, ankyrin repeat domain 27
External IDs	MGI: 2444103; HomoloGene: 12956; GeneCards: ANKRD27; OMA:ANKRD27 - orthologs
Gene location (Human)
Chr.	Chromosome 19 (human)
End	32,676,597 bp
Gene location (Mouse)
Chr.	Chromosome 7 (mouse)
End	35,338,651 bp
RNA expression pattern
	Top expressed in
	Epithelium of choroid plexus; ; amniotic fluid; ; skin of thigh; ; palpebral conjunctiva; ; Brodmann area 23; ; tail of epididymis; ; seminal vesicula; ; epithelium of nasopharynx; ; lower lobe of lung; ; testicle;
	Top expressed in
	neural layer of retina; ; ascending aorta; ; lacrimal gland; ; zygote; ; aortic valve; ; tail of embryo; ; lumbar spinal ganglion; ; parotid gland; ; epiblast; ; oocyte;
	More reference expression data
	More reference expression data
Gene ontology
Molecular function	GTPase activator activity; guanyl-nucleotide exchange factor activity; protein binding; SNARE binding;
Cellular component	endosome; late endosome; membrane; melanosome; plasma membrane; transport vesicle; tubular endosome; early endosome; lysosome; cytoplasmic vesicle membrane; cytoplasmic vesicle; cytosol; neuron projection;
Biological process	negative regulation of SNARE complex assembly; early endosome to late endosome transport; positive regulation of dendrite morphogenesis; endosome to melanosome transport; protein transport; positive regulation of GTPase activity; neuron projection morphogenesis; transport; regulation of molecular function; positive regulation of neuron projection development;
	Sources:Amigo / QuickGO
Orthologs
	84079
	245886
	ENSG00000105186
	ENSMUSG00000034867
	Q96NW4
	Q3UMR0
	NM_032139
	NM_145633; NM_178263; NM_001358876
	NP_115515
	NP_663608; NP_839994; NP_001345805
	Wikidata
View/Edit Human	View/Edit Mouse

Ankyrin repeat domain-containing protein 27 is a protein that in humans is encoded by the ANKRD27 gene.^[5]^[6]^[7]

References

^ ^a ^b ^c GRCh38: Ensembl release 89: ENSG00000105186 – Ensembl, May 2017
^ ^a ^b ^c GRCm38: Ensembl release 89: ENSMUSG00000034867 – Ensembl, May 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ Wiemann S, Weil B, Wellenreuther R, Gassenhuber J, Glassl S, Ansorge W, Bocher M, Blocker H, Bauersachs S, Blum H, Lauber J, Dusterhoft A, Beyer A, Kohrer K, Strack N, Mewes HW, Ottenwalder B, Obermaier B, Tampe J, Heubner D, Wambutt R, Korn B, Klein M, Poustka A (Mar 2001). "Toward a Catalog of Human Genes and Proteins: Sequencing and Analysis of 500 Novel Complete Protein Coding Human cDNAs". Genome Res. 11 (3): 422–35. doi:10.1101/gr.GR1547R. PMC 311072. PMID 11230166.
^ Zhang X, He X, Fu XY, Chang Z (Mar 2006). "Varp is a Rab21 guanine nucleotide exchange factor and regulates endosome dynamics". J Cell Sci. 119 (Pt 6): 1053–62. doi:10.1242/jcs.02810. PMID 16525121.
^ "Entrez Gene: ANKRD27 ankyrin repeat domain 27 (VPS9 domain)".

External links

Human ANKRD27 genome location and ANKRD27 gene details page in the UCSC Genome Browser.

Hartley JL, Temple GF, Brasch MA (2001). "DNA Cloning Using In Vitro Site-Specific Recombination". Genome Res. 10 (11): 1788–95. doi:10.1101/gr.143000. PMC 310948. PMID 11076863.
Simpson JC, Wellenreuther R, Poustka A, et al. (2001). "Systematic subcellular localization of novel proteins identified by large-scale cDNA sequencing". EMBO Rep. 1 (3): 287–92. doi:10.1093/embo-reports/kvd058. PMC 1083732. PMID 11256614.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.
Colland F, Jacq X, Trouplin V, et al. (2004). "Functional Proteomics Mapping of a Human Signaling Pathway". Genome Res. 14 (7): 1324–32. doi:10.1101/gr.2334104. PMC 442148. PMID 15231748.
Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The Status, Quality, and Expansion of the NIH Full-Length cDNA Project: The Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
Wiemann S, Arlt D, Huber W, et al. (2004). "From ORFeome to Biology: A Functional Genomics Pipeline". Genome Res. 14 (10B): 2136–44. doi:10.1101/gr.2576704. PMC 528930. PMID 15489336.
Wan D, Gong Y, Qin W, et al. (2004). "Large-scale cDNA transfection screening for genes related to cancer development and progression". Proc. Natl. Acad. Sci. U.S.A. 101 (44): 15724–9. Bibcode:2004PNAS..10115724W. doi:10.1073/pnas.0404089101. PMC 524842. PMID 15498874.
Mehrle A, Rosenfelder H, Schupp I, et al. (2006). "The LIFEdb database in 2006". Nucleic Acids Res. 34 (Database issue): D415–8. doi:10.1093/nar/gkj139. PMC 1347501. PMID 16381901.

This article on a gene on human chromosome 19 is a stub. You can help Wikipedia by expanding it.

[refGRCh38Ensembl-1] GRCh38: Ensembl release 89: ENSG00000105186 – Ensembl, May 2017

[refGRCm38Ensembl-2] GRCm38: Ensembl release 89: ENSMUSG00000034867 – Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[pmid11230166-5] Wiemann S, Weil B, Wellenreuther R, Gassenhuber J, Glassl S, Ansorge W, Bocher M, Blocker H, Bauersachs S, Blum H, Lauber J, Dusterhoft A, Beyer A, Kohrer K, Strack N, Mewes HW, Ottenwalder B, Obermaier B, Tampe J, Heubner D, Wambutt R, Korn B, Klein M, Poustka A (Mar 2001). "Toward a Catalog of Human Genes and Proteins: Sequencing and Analysis of 500 Novel Complete Protein Coding Human cDNAs". Genome Res. 11 (3): 422–35. doi:10.1101/gr.GR1547R. PMC 311072. PMID 11230166.

[pmid16525121-6] Zhang X, He X, Fu XY, Chang Z (Mar 2006). "Varp is a Rab21 guanine nucleotide exchange factor and regulates endosome dynamics". J Cell Sci. 119 (Pt 6): 1053–62. doi:10.1242/jcs.02810. PMID 16525121.

[entrez-7] "Entrez Gene: ANKRD27 ankyrin repeat domain 27 (VPS9 domain)".

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References

External links

Further reading