PLA2R1

PLA2R1
Identifiers
Aliases	PLA2R1, CLEC13C, PLA2-R, PLA2G1R, PLA2IR, PLA2R, phospholipase A2 receptor 1
External IDs	OMIM: 604939; MGI: 102468; HomoloGene: 32016; GeneCards: PLA2R1; OMA:PLA2R1 - orthologs
Gene location (Human)
Chr.	Chromosome 2 (human)
End	160,062,615 bp
Gene location (Mouse)
Chr.	Chromosome 2 (mouse)
End	60,383,652 bp
RNA expression pattern
	Top expressed in
	parotid gland; ; left lobe of thyroid gland; ; Achilles tendon; ; right lobe of thyroid gland; ; right coronary artery; ; popliteal artery; ; tibial arteries; ; olfactory zone of nasal mucosa; ; Descending thoracic aorta; ; skin of leg;
	Top expressed in
	neural layer of retina; ; transitional epithelium of urinary bladder; ; molar; ; olfactory epithelium; ; retinal pigment epithelium; ; decidua; ; pineal gland; ; umbilical cord; ; gastrula; ; uterus;
	More reference expression data
	More reference expression data
Gene ontology
Molecular function	phospholipase binding; carbohydrate binding; transmembrane signaling receptor activity; signaling receptor activity;
Cellular component	integral component of membrane; extracellular region; cell surface; receptor complex; plasma membrane; membrane; integral component of plasma membrane;
Biological process	cytokine production; positive regulation of DNA damage response, signal transduction by p53 class mediator; endocytosis; positive regulation of arachidonic acid secretion; receptor-mediated endocytosis; oxidative stress-induced premature senescence; reactive oxygen species metabolic process; replicative senescence; signal transduction; negative regulation of phospholipase A2 activity; negative regulation of arachidonic acid secretion;
	Sources:Amigo / QuickGO
Orthologs
	22925
	18779
	ENSG00000153246
	ENSMUSG00000054580
	Q13018
	Q62028
	NM_001007267; NM_001195641; NM_007366
	NM_008867
	NP_001007268; NP_001182570; NP_031392
	NP_032893
	Wikidata
View/Edit Human	View/Edit Mouse

Secretory phospholipase A2 receptor is a protein that in humans is encoded by the PLA2R1 gene.^[5]^[6]^[7]

Clinical significance

M-type phospholipase A2 receptor is the major antigen in idiopathic membranous nephropathy attributed to over 70% of cases.^[8]

References

^ ^a ^b ^c GRCh38: Ensembl release 89: ENSG00000153246 – Ensembl, May 2017
^ ^a ^b ^c GRCm38: Ensembl release 89: ENSMUSG00000054580 – Ensembl, May 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ Ancian P, Lambeau G, Mattéi MG, Lazdunski M (Apr 1995). "The human 180-kDa receptor for secretory phospholipases A2. Molecular cloning, identification of a secreted soluble form, expression, and chromosomal localization". The Journal of Biological Chemistry. 270 (15): 8963–70. doi:10.1074/jbc.270.15.8963. PMID 7721806.
^ Higashino K, Ishizaki J, Kishino J, Ohara O, Arita H (Oct 1994). "Structural comparison of phospholipase-A2-binding regions in phospholipase-A2 receptors from various mammals". European Journal of Biochemistry. 225 (1): 375–82. doi:10.1111/j.1432-1033.1994.00375.x. PMID 7925459.
^ "Entrez Gene: PLA2R1 phospholipase A2 receptor 1, 180kDa".
^ Beck LH, Bonegio RG, Lambeau G, Beck DM, Powell DW, Cummins TD, Klein JB, Salant DJ (Jul 2009). "M-type phospholipase A2 receptor as target antigen in idiopathic membranous nephropathy". The New England Journal of Medicine. 361 (1): 11–21. doi:10.1056/NEJMoa0810457. PMC 2762083. PMID 19571279.

Silliman CC, Moore EE, Zallen G, Gonzalez R, Johnson JL, Elzi DJ, Meng X, Hanasaki K, Ishizaki J, Arita H, Ao L, England KM, Banerjee A (Oct 2002). "Presence of the M-type sPLA(2) receptor on neutrophils and its role in elastase release and adhesion". American Journal of Physiology. Cell Physiology. 283 (4): C1102–13. doi:10.1152/ajpcell.00608.2001. PMID 12225974.
Wistow G, Bernstein SL, Wyatt MK, Ray S, Behal A, Touchman JW, Bouffard G, Smith D, Peterson K (Jun 2002). "Expressed sequence tag analysis of human retina for the NEIBank Project: retbindin, an abundant, novel retinal cDNA and alternative splicing of other retina-preferred gene transcripts". Molecular Vision. 8: 196–204. PMID 12107411.
Morioka Y, Saiga A, Yokota Y, Suzuki N, Ikeda M, Ono T, Nakano K, Fujii N, Ishizaki J, Arita H, Hanasaki K (Sep 2000). "Mouse group X secretory phospholipase A2 induces a potent release of arachidonic acid from spleen cells and acts as a ligand for the phospholipase A2 receptor". Archives of Biochemistry and Biophysics. 381 (1): 31–42. doi:10.1006/abbi.2000.1977. PMID 11019817.
Yokota Y, Higashino K, Nakano K, Arita H, Hanasaki K (Jul 2000). "Identification of group X secretory phospholipase A(2) as a natural ligand for mouse phospholipase A(2) receptor". FEBS Letters. 478 (1–2): 187–91. doi:10.1016/S0014-5793(00)01848-2. PMID 10922494. S2CID 28188560.
Yokota Y, Ikeda M, Higashino K, Nakano K, Fujii N, Arita H, Hanasaki K (Jul 2000). "Enhanced tissue expression and elevated circulating level of phospholipase A(2) receptor during murine endotoxic shock". Archives of Biochemistry and Biophysics. 379 (1): 7–17. doi:10.1006/abbi.2000.1849. PMID 10864436.
Dias Neto E, Correa RG, Verjovski-Almeida S, Briones MR, Nagai MA, da Silva W, Zago MA, Bordin S, Costa FF, Goldman GH, Carvalho AF, Matsukuma A, Baia GS, Simpson DH, Brunstein A, de Oliveira PS, Bucher P, Jongeneel CV, O'Hare MJ, Soares F, Brentani RR, Reis LF, de Souza SJ, Simpson AJ (Mar 2000). "Shotgun sequencing of the human transcriptome with ORF expressed sequence tags". Proceedings of the National Academy of Sciences of the United States of America. 97 (7): 3491–6. Bibcode:2000PNAS...97.3491D. doi:10.1073/pnas.97.7.3491. PMC 16267. PMID 10737800.

This article on a gene on human chromosome 2 is a stub. You can help Wikipedia by expanding it.

[refGRCh38Ensembl-1] GRCh38: Ensembl release 89: ENSG00000153246 – Ensembl, May 2017

[refGRCm38Ensembl-2] GRCm38: Ensembl release 89: ENSMUSG00000054580 – Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[pmid7721806-5] Ancian P, Lambeau G, Mattéi MG, Lazdunski M (Apr 1995). "The human 180-kDa receptor for secretory phospholipases A2. Molecular cloning, identification of a secreted soluble form, expression, and chromosomal localization". The Journal of Biological Chemistry. 270 (15): 8963–70. doi:10.1074/jbc.270.15.8963. PMID 7721806.

[pmid7925459-6] Higashino K, Ishizaki J, Kishino J, Ohara O, Arita H (Oct 1994). "Structural comparison of phospholipase-A2-binding regions in phospholipase-A2 receptors from various mammals". European Journal of Biochemistry. 225 (1): 375–82. doi:10.1111/j.1432-1033.1994.00375.x. PMID 7925459.

[entrez-7] "Entrez Gene: PLA2R1 phospholipase A2 receptor 1, 180kDa".

[8] Beck LH, Bonegio RG, Lambeau G, Beck DM, Powell DW, Cummins TD, Klein JB, Salant DJ (Jul 2009). "M-type phospholipase A2 receptor as target antigen in idiopathic membranous nephropathy". The New England Journal of Medicine. 361 (1): 11–21. doi:10.1056/NEJMoa0810457. PMC 2762083. PMID 19571279.

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Clinical significance

References

Further reading