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Frances Platt

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Fran Platt
FMedSci FRS MAE
Born
Frances Judson
Alma materImperial College London
University of Bath
Scientific career
InstitutionsUniversity of Oxford
Washington University School of Medicine
ThesisMonoclonal antibody studies on the prothoracic glands of Manduca sexta (1986)
Websiteplattlab.nsms.ox.ac.uk

Frances Mary Platt (née Judson) FMedSci FRS MAE is a British biochemist and pharmacologist who is a professor at the University of Oxford.[1] Her research investigates rare genetic disorders known as lysosomal storage diseases, progressive conditions that lead to neurodegeneration. She was elected Fellow of the Royal Society in 2021.

Early life and education

Platt was interested in insects as a child. Her father was a general practitioner.[2] Platt was an undergraduate student at Imperial College London, where she majored in zoology.[2] She moved to the University of Bath for her graduate studies. Her doctoral research looking at the impact of monoclonal antibodies on the prothoracic glands of Manduca sexta.[3] Platt was a postdoctoral researcher at the Washington University School of Medicine, where she investigated how abnormal accumulation of glycosphingolipids.[4] During her final year, her boss moved to the pharmaceutical arm of Monsanto, where Platt became aware of industrial research and antiviral drugs.[2]

Research and career

In 1996, Platt was appointed as a senior research fellow at the Lister Institute of Preventive Medicine. She moved to the University of Oxford in 2006, where she was named Head of the Department of Pharmacology in 2020.[5]

Platt studies genetic disorders known as lysosomal storage diseases.[1] The lysosome is a compartment within cells that is involved with breaking down large molecules. When it goes wrong, molecules accumulate in the lysosome (so-called “storage,”). Specifically, Platt is particularly interested in the build up of sphingolipids, the build-up of which can cause neurodegeneration.[6] Platt looks to better understand these conditions as well as developing novel therapeutic pathways.[4] In particular, Platt developed substrate reduction therapies.[4]

Platt identified that a drug she was investigating as an antiviral was effective in treating lysosomal diseases. She managed to get the drug (Miglustat) approved by the European Medicines Agency and Food and Drug Administration for the treatment of both Gaucher's disease and Niemann–Pick disease.[7]

Awards and honours

Selected publications

  • Barry Boland; Asok Kumar; Sooyeon Lee; Frances M Platt; Jerzy Wegiel; W Haung Yu; Ralph A Nixon (1 July 2008). "Autophagy induction and autophagosome clearance in neurons: relationship to autophagic pathology in Alzheimer's disease". The Journal of Neuroscience. 28 (27): 6926–6937. doi:10.1523/JNEUROSCI.0800-08.2008. ISSN 0270-6474. PMC 2676733. PMID 18596167. Wikidata Q37178375.
  • Timothy Cox; Robin Lachmann; Carla Hollak; et al. (1 April 2000). "Novel oral treatment of Gaucher's disease with N-butyldeoxynojirimycin (OGT 918) to decrease substrate biosynthesis". The Lancet. 355 (9214): 1481–1485. doi:10.1016/S0140-6736(00)02161-9. ISSN 0140-6736. PMID 10801168. Wikidata Q53912470.
  • Raymond A Dwek; Terry D Butters; Frances M Platt; Nicole Zitzmann (1 January 2002). "Targeting glycosylation as a therapeutic approach". Nature Reviews Drug Discovery. 1 (1): 65–75. doi:10.1038/NRD708. ISSN 1474-1776. PMID 12119611. Wikidata Q34741569.

Personal life

Platt has two children.[2]

References

  1. ^ a b Frances Platt publications from Europe PubMed Central
  2. ^ a b c d "Fran Platt — Diversity Projects". parking.haiku.fry-it.com. Retrieved 2021-05-15.
  3. ^ Judson, Frances (1986). Monoclonal antibody studies on the prothoracic glands of Manduca sexta. bath.ac.uk (PhD thesis). OCLC 59702665. EThOS uk.bl.ethos.374968. Retrieved 2021-05-15.
  4. ^ a b c "Frances Platt". pharm.ox.ac.uk. Retrieved 2021-05-15.
  5. ^ "Frances M. Platt, PhD | Parkinson's Disease". michaeljfox.org. Retrieved 2021-05-15.
  6. ^ a b "Frances Platt | Royal Society". royalsociety.org. Retrieved 2021-05-15.
  7. ^ "Frances M. Platt, PhD | Parkinson's Disease". www.michaeljfox.org. Retrieved 2021-05-15.
  8. ^ "Alan Gordon award". gaucher.org.uk. Retrieved 2021-05-15.
  9. ^ a b "Academy of Europe: Platt Frances Mary". ae-info.org. Retrieved 2021-05-15.
  10. ^ "Professor Frances Platt | The Academy of Medical Sciences". acmedsci.ac.uk. Retrieved 2021-05-15.
  11. ^ "Frances Platt receives Royal Society Wolfson Research Merit Award". Merton College, Oxford. Retrieved 2021-05-15.
  12. ^ "Our Scientists | IntraBio". 2018-04-20. Retrieved 2021-05-15.
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