This is the current revision of this page, as edited by Staalmannen(talk | contribs) at 15:56, 1 February 2023(Removed reference to apoptosis in the CARD domain segment. It is a PPI domain and not all CARDs induce apoptosis.). The present address (URL) is a permanent link to this version.
Revision as of 15:56, 1 February 2023 by Staalmannen(talk | contribs)(Removed reference to apoptosis in the CARD domain segment. It is a PPI domain and not all CARDs induce apoptosis.)
The caspase recruitment domain (CARD) is a protein module that consists of 6 or 7 antiparallel alpha helices. It participates in signaling through highly specific protein-protein homophilic interactions. CARDs induce nuclear factor kappa-B (NF-κB; MIM 164011) activity through the IKK (e.g., IKBKB; MIM 603258) complex. CARD9 (MIM 607212), CARD10, CARD11 (MIM 607210), and CARD14 (MIM 607211) interact with BCL10 (MIM 603517) and are involved in NF-κB signaling complexes. Except for CARD9, these CARD proteins are members of the membrane-associated guanylate kinase (MAGUK) family.[supplied by OMIM][7]