SEMA4C

SEMA4C
Identifiers
Aliases	SEMA4C, M-SEMA-F, SEMACL1, SEMAF, SEMAI, semaphorin 4C
External IDs	OMIM: 604462; MGI: 109252; HomoloGene: 23047; GeneCards: SEMA4C; OMA:SEMA4C - orthologs
Gene location (Human)
Chr.	Chromosome 2 (human)
End	96,870,757 bp
Gene location (Mouse)
Chr.	Chromosome 1 (mouse)
End	36,597,430 bp
RNA expression pattern
	Top expressed in
	olfactory bulb; ; trigeminal ganglion; ; spinal ganglia; ; cerebellar vermis; ; tibial nerve; ; inferior ganglion of vagus nerve; ; sural nerve; ; inferior olivary nucleus; ; endothelial cell; ; pericardium;
	Top expressed in
	sciatic nerve; ; trigeminal ganglion; ; aortic valve; ; Rostral migratory stream; ; otolith organ; ; utricle; ; ascending aorta; ; ganglionic eminence; ; tail of embryo; ; decidua;
	More reference expression data
	; ;
	More reference expression data
Gene ontology
Molecular function	protein binding; neuropilin binding; semaphorin receptor binding; chemorepellent activity;
Cellular component	integral component of membrane; postsynaptic membrane; postsynaptic density; plasma membrane; synapse; synaptic vesicle membrane; cell junction; cytoplasmic vesicle; extracellular space; membrane; integral component of plasma membrane;
Biological process	cell differentiation; cell migration in hindbrain; cerebellum development; nervous system development; multicellular organism development; muscle cell differentiation; neural tube closure; positive regulation of stress-activated MAPK cascade; semaphorin-plexin signaling pathway; negative chemotaxis; neural crest cell migration; positive regulation of cell migration; negative regulation of axon extension involved in axon guidance;
	Sources:Amigo / QuickGO
Orthologs
	54910
	20353
	ENSG00000168758
	ENSMUSG00000026121
	Q9C0C4
	Q64151
	NM_017789
	NM_001126047; NM_001304329; NM_001304330
	NP_060259
	NP_001119519; NP_001291258; NP_001291259
	Wikidata
View/Edit Human	View/Edit Mouse

Semaphorin-4C is a protein that in humans is encoded by the SEMA4C gene.^[5]^[6]

Interactions

SEMA4C has been shown to interact with DLG4.^[7]

References

^ ^a ^b ^c GRCh38: Ensembl release 89: ENSG00000168758 – Ensembl, May 2017
^ ^a ^b ^c GRCm38: Ensembl release 89: ENSMUSG00000026121 – Ensembl, May 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ Inagaki S, Furuyama T, Iwahashi Y (October 1995). "Identification of a member of mouse semaphorin family". FEBS Lett. 370 (3): 269–72. doi:10.1016/0014-5793(95)00850-9. PMID 7656991.
^ "Entrez Gene: SEMA4C sema domain, immunoglobulin domain (Ig), transmembrane domain (TM) and short cytoplasmic domain, (semaphorin) 4C".
^ Inagaki S, Ohoka Y, Sugimoto H, Fujioka S, Amazaki M, Kurinami H, Miyazaki N, Tohyama M, Furuyama T (March 2001). "Sema4c, a transmembrane semaphorin, interacts with a post-synaptic density protein, PSD-95". J. Biol. Chem. 276 (12): 9174–81. doi:10.1074/jbc.M009051200. PMID 11134026.

Simmons AD, Püschel AW, McPherson JD, Overhauser J, Lovett M (1998). "Molecular cloning and mapping of human semaphorin F from the Cri-du-chat candidate interval". Biochem. Biophys. Res. Commun. 242 (3): 685–91. doi:10.1006/bbrc.1997.8027. PMID 9464278.
Wang LH, Kalb RG, Strittmatter SM (1999). "A PDZ protein regulates the distribution of the transmembrane semaphorin, M-SemF". J. Biol. Chem. 274 (20): 14137–46. doi:10.1074/jbc.274.20.14137. PMID 10318831.
Inagaki S, Ohoka Y, Sugimoto H, Fujioka S, Amazaki M, Kurinami H, Miyazaki N, Tohyama M, Furuyama T (2001). "Sema4c, a transmembrane semaphorin, interacts with a post-synaptic density protein, PSD-95". J. Biol. Chem. 276 (12): 9174–81. doi:10.1074/jbc.M009051200. PMID 11134026.
Ohoka Y, Hirotani M, Sugimoto H, Fujioka S, Furuyama T, Inagaki S (2001). "Semaphorin 4C, a transmembrane semaphorin, [corrected] associates with a neurite-outgrowth-related protein, SFAP75". Biochem. Biophys. Res. Commun. 280 (1): 237–43. doi:10.1006/bbrc.2000.4080. PMID 11162505.
Nagase T, Kikuno R, Hattori A, Kondo Y, Okumura K, Ohara O (2001). "Prediction of the coding sequences of unidentified human genes. XIX. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro". DNA Res. 7 (6): 347–55. doi:10.1093/dnares/7.6.347. PMID 11214970.

This article on a gene on human chromosome 2 is a stub. You can help Wikipedia by expanding it.

[refGRCh38Ensembl-1] GRCh38: Ensembl release 89: ENSG00000168758 – Ensembl, May 2017

[refGRCm38Ensembl-2] GRCm38: Ensembl release 89: ENSMUSG00000026121 – Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[pmid7656991-5] Inagaki S, Furuyama T, Iwahashi Y (October 1995). "Identification of a member of mouse semaphorin family". FEBS Lett. 370 (3): 269–72. doi:10.1016/0014-5793(95)00850-9. PMID 7656991.

[entrez-6] "Entrez Gene: SEMA4C sema domain, immunoglobulin domain (Ig), transmembrane domain (TM) and short cytoplasmic domain, (semaphorin) 4C".

[pmid11134026-7] Inagaki S, Ohoka Y, Sugimoto H, Fujioka S, Amazaki M, Kurinami H, Miyazaki N, Tohyama M, Furuyama T (March 2001). "Sema4c, a transmembrane semaphorin, interacts with a post-synaptic density protein, PSD-95". J. Biol. Chem. 276 (12): 9174–81. doi:10.1074/jbc.M009051200. PMID 11134026.

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Interactions

References

Further reading