METTL1

METTL1
Available structures
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	3CKK
Identifiers
Aliases	METTL1, C12orf1, TRM8, TRMT8, YDL201w, methyltransferase like 1, methyltransferase 1, tRNA methylguanosine
External IDs	OMIM: 604466; MGI: 1339986; HomoloGene: 3918; GeneCards: METTL1; OMA:METTL1 - orthologs
Gene location (Human)
Chr.	Chromosome 12 (human)
End	57,772,119 bp
Gene location (Mouse)
Chr.	Chromosome 10 (mouse)
End	127,046,365 bp
RNA expression pattern
	Top expressed in
	body of pancreas; ; gonad; ; pancreatic ductal cell; ; left adrenal cortex; ; right adrenal gland; ; testicle; ; right lobe of thyroid gland; ; right adrenal cortex; ; stromal cell of endometrium; ; left lobe of thyroid gland;
	Top expressed in
	lacrimal gland; ; yolk sac; ; epiblast; ; embryo; ; blastocyst; ; embryo; ; right kidney; ; morula; ; proximal tubule; ; primitive streak;
	More reference expression data
	More reference expression data
Gene ontology
Molecular function	methyltransferase activity; transferase activity; tRNA binding; tRNA (guanine-N7-)-methyltransferase activity; protein binding; RNA binding;
Cellular component	tRNA methyltransferase complex; nucleolus; nucleus; nucleoplasm; cytosol;
Biological process	methylation; tRNA modification; tRNA processing; tRNA (guanine-N7)-methylation; tRNA methylation; RNA (guanine-N7)-methylation;
	Sources:Amigo / QuickGO
Orthologs
	4234
	17299
	ENSG00000037897
	ENSMUSG00000006732
	Q9UBP6
	Q9Z120
	NM_005371; NM_023032; NM_023033
	NM_010792
	NP_005362; NP_075422
	NP_034922
	Wikidata
View/Edit Human	View/Edit Mouse

tRNA (guanine-N(7)-)-methyltransferase is an enzyme that in humans is encoded by the METTL1 gene.^[5]^[6]

This gene is similar in sequence to the S. cerevisiae YDL201w gene. The gene product contains a conserved S-adenosylmethionine-binding motif and is inactivated by phosphorylation. Alternative splice variants encoding different protein isoforms and transcript variants utilizing alternative polyA sites have been described in the literature.^[6]

References

^ ^a ^b ^c GRCh38: Ensembl release 89: ENSG00000037897 – Ensembl, May 2017
^ ^a ^b ^c GRCm38: Ensembl release 89: ENSMUSG00000006732 – Ensembl, May 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ Bahr A, Hankeln T, Fiedler T, Hegemann J, Schmidt ER (Aug 1999). "Molecular analysis of METTL1, a novel human methyltransferase-like gene with a high degree of phylogenetic conservation". Genomics. 57 (3): 424–8. doi:10.1006/geno.1999.5780. PMID 10329009.
^ ^a ^b "Entrez Gene: METTL1 methyltransferase like 1".

Maruyama K, Sugano S (1994). "Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides". Gene. 138 (1–2): 171–4. doi:10.1016/0378-1119(94)90802-8. PMID 8125298.
Suzuki Y, Yoshitomo-Nakagawa K, Maruyama K, et al. (1997). "Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library". Gene. 200 (1–2): 149–56. doi:10.1016/S0378-1119(97)00411-3. PMID 9373149.
Alexandrov A, Martzen MR, Phizicky EM (2002). "Two proteins that form a complex are required for 7-methylguanosine modification of yeast tRNA". RNA. 8 (10): 1253–66. doi:10.1017/S1355838202024019. PMC 1370335. PMID 12403464.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
Izmailova E, Bertley FM, Huang Q, et al. (2003). "HIV-1 Tat reprograms immature dendritic cells to express chemoattractants for activated T cells and macrophages". Nat. Med. 9 (2): 191–7. doi:10.1038/nm822. PMID 12539042. S2CID 26145639.
Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
Cartlidge RA, Knebel A, Peggie M, et al. (2005). "The tRNA methylase METTL1 is phosphorylated and inactivated by PKB and RSK in vitro and in cells". EMBO J. 24 (9): 1696–705. doi:10.1038/sj.emboj.7600648. PMC 1142581. PMID 15861136.
Rual JF, Venkatesan K, Hao T, et al. (2005). "Towards a proteome-scale map of the human protein-protein interaction network". Nature. 437 (7062): 1173–8. Bibcode:2005Natur.437.1173R. doi:10.1038/nature04209. PMID 16189514. S2CID 4427026.

This article on a gene on human chromosome 12 is a stub. You can help Wikipedia by expanding it.

[refGRCh38Ensembl-1] GRCh38: Ensembl release 89: ENSG00000037897 – Ensembl, May 2017

[refGRCm38Ensembl-2] GRCm38: Ensembl release 89: ENSMUSG00000006732 – Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[pmid10329009-5] Bahr A, Hankeln T, Fiedler T, Hegemann J, Schmidt ER (Aug 1999). "Molecular analysis of METTL1, a novel human methyltransferase-like gene with a high degree of phylogenetic conservation". Genomics. 57 (3): 424–8. doi:10.1006/geno.1999.5780. PMID 10329009.

[entrez-6] "Entrez Gene: METTL1 methyltransferase like 1".

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[6]

METTL1

See also

References

Further reading