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Protein-coding gene in the species Homo sapiens
Leucine-rich repeat serine/threonine-protein kinase 1 is an enzyme that in humans is encoded by the LRRK1 gene .[ 5] [ 6] [ 7]
References
^ a b c GRCh38: Ensembl release 89: ENSG00000154237 – Ensembl , May 2017^ a b c GRCm38: Ensembl release 89: ENSMUSG00000015133 – Ensembl , May 2017^ "Human PubMed Reference:" . National Center for Biotechnology Information, U.S. National Library of Medicine .^ "Mouse PubMed Reference:" . National Center for Biotechnology Information, U.S. National Library of Medicine .^ Nagase T, Nakayama M, Nakajima D, Kikuno R, Ohara O (May 2001). "Prediction of the coding sequences of unidentified human genes. XX. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro" . DNA Res . 8 (2): 85–95. doi :10.1093/dnares/8.2.85 PMID 11347906 . ^ Bosgraaf L, Van Haastert PJ (Dec 2003). "Roc, a Ras/GTPase domain in complex proteins" (PDF) . Biochim Biophys Acta . 1643 (1–3): 5–10. doi :10.1016/j.bbamcr.2003.08.008 . PMID 14654223 . ^ "Entrez Gene: LRRK1 leucine-rich repeat kinase 1" .
Further reading
Maruyama K, Sugano S (1994). "Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides". Gene . 138 (1–2): 171–4. doi :10.1016/0378-1119(94)90802-8 . PMID 8125298 . Bonaldo MF, Lennon G, Soares MB (1997). "Normalization and subtraction: two approaches to facilitate gene discovery" . Genome Res . 6 (9): 791–806. doi :10.1101/gr.6.9.791 PMID 8889548 . Suzuki Y, Yoshitomo-Nakagawa K, Maruyama K, et al. (1997). "Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library". Gene . 200 (1–2): 149–56. doi :10.1016/S0378-1119(97)00411-3 . PMID 9373149 . Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences" . Proc. Natl. Acad. Sci. U.S.A . 99 (26): 16899–903. Bibcode :2002PNAS...9916899M . doi :10.1073/pnas.242603899 PMC 139241 PMID 12477932 . Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs" . Nat. Genet . 36 (1): 40–5. doi :10.1038/ng1285 PMID 14702039 . Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)" . Genome Res . 14 (10B): 2121–7. doi :10.1101/gr.2596504 . PMC 528928 PMID 15489334 . Korr D, Toschi L, Donner P, et al. (2006). "LRRK1 protein kinase activity is stimulated upon binding of GTP to its Roc domain". Cell. Signal . 18 (6): 910–20. doi :10.1016/j.cellsig.2005.08.015 . PMID 16243488 . Zody MC, Garber M, Sharpe T, et al. (2006). "Analysis of the DNA sequence and duplication history of human chromosome 15" . Nature . 440 (7084): 671–5. Bibcode :2006Natur.440..671Z . doi :10.1038/nature04601 PMID 16572171 . Haugarvoll K, Toft M, Ross OA, et al. (2007). "Variants in the LRRK1 gene and susceptibility to Parkinson's disease in Norway". Neurosci. Lett . 416 (3): 299–301. doi :10.1016/j.neulet.2007.02.020 . PMID 17324517 . S2CID 10196943 . Ewing RM, Chu P, Elisma F, et al. (2007). "Large-scale mapping of human protein-protein interactions by mass spectrometry" . Mol. Syst. Biol . 3 (1): 89. doi :10.1038/msb4100134 . PMC 1847948 PMID 17353931 . Greggio E, Lewis PA, van der Brug MP, et al. (2007). "Mutations in LRRK2/dardarin associated with Parkinson disease are more toxic than equivalent mutations in the homologous kinase LRRK1" . J. Neurochem . 102 (1): 93–102. doi :10.1111/j.1471-4159.2007.04523.x PMID 17394548 .
