Revision as of 12:55, 2 August 2023 by Heavy Grasshopper(talk | contribs)(Changing short description from "Mammalian protein found in Homo sapiens" to "Mammalian protein found in humans")
Melanoma-associated antigen 1 is a protein that in humans is encoded by the MAGEA1gene.[3]
This gene is a member of the MAGEA gene family. The members of this family encode proteins with 50 to 80% sequence identity to each other. The promoters and first exons of the MAGEA genes show considerable variability, suggesting that the existence of this gene family enables the same function to be expressed under different transcriptional controls. The MAGEA genes are clustered at chromosomal location Xq28. They have been implicated in some hereditary disorders, such as dyskeratosis congenita.[4]
^"Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^van der Bruggen P, Traversari C, Chomez P, Lurquin C, De Plaen E, Van den Eynde B, Knuth A, Boon T (Jan 1992). "A gene encoding an antigen recognized by cytolytic T lymphocytes on a human melanoma". Science. 254 (5038): 1643–7. doi:10.1126/science.1840703. PMID1840703.
Takahashi K, Shichijo S, Noguchi M, et al. (1995). "Identification of MAGE-1 and MAGE-4 proteins in spermatogonia and primary spermatocytes of testis". Cancer Res. 55 (16): 3478–82. PMID7627949.
Celis E, Fikes J, Wentworth P, et al. (1995). "Identification of potential CTL epitopes of tumor-associated antigen MAGE-1 for five common HLA-A alleles". Mol. Immunol. 31 (18): 1423–30. doi:10.1016/0161-5890(94)90158-9. PMID7823968.
De Plaen E, Arden K, Traversari C, et al. (1994). "Structure, chromosomal localization, and expression of 12 genes of the MAGE family". Immunogenetics. 40 (5): 360–9. doi:10.1007/BF01246677. PMID7927540. S2CID11331427.
Becker JC, Gillitzer R, Bröcker EB (1994). "A member of the melanoma antigen-encoding gene (MAGE) family is expressed in human skin during wound healing". Int. J. Cancer. 58 (3): 346–8. doi:10.1002/ijc.2910580306. PMID8050815. S2CID43714786.
Rogner UC, Wilke K, Steck E, et al. (1996). "The melanoma antigen gene (MAGE) family is clustered in the chromosomal band Xq28". Genomics. 29 (3): 725–31. doi:10.1006/geno.1995.9945. PMID8575766.
Tanzarella S, Russo V, Lionello I, et al. (1999). "Identification of a promiscuous T-cell epitope encoded by multiple members of the MAGE family". Cancer Res. 59 (11): 2668–74. PMID10363990.
Jang SJ, Soria JC, Wang L, et al. (2001). "Activation of melanoma antigen tumor antigens occurs early in lung carcinogenesis". Cancer Res. 61 (21): 7959–63. PMID11691819.
Suyama T, Ohashi H, Nagai H, et al. (2003). "The MAGE-A1 gene expression is not determined solely by methylation status of the promoter region in hematological malignancies". Leuk. Res. 26 (12): 1113–8. doi:10.1016/S0145-2126(02)00048-6. PMID12443884.
Zerbini A, Pilli M, Soliani P, et al. (2004). "Ex vivo characterization of tumor-derived melanoma antigen encoding gene-specific CD8+cells in patients with hepatocellular carcinoma". J. Hepatol. 40 (1): 102–9. doi:10.1016/S0168-8278(03)00484-7. PMID14672620.
Wang LP, Chen HS, Mei MH, et al. (2004). "[The genetic polymorphism of melanoma-associated antigen 1 in Chinese normal donors and hepatoma patients]". Zhonghua Gan Zang Bing Za Zhi. 12 (3): 151–5. PMID15059299.
External links
Overview of all the structural information available in the PDB for UniProt: P43355 (Melanoma-associated antigen 1) at the PDBe-KB.