BCL7A

BCL7A
Identifiers
Aliases	BCL7A, BCL7, B-cell CLL/lymphoma 7A, BCL tumor suppressor 7A, BAF complex component, BAF chromatin remodeling complex subunit SMARCJ1
External IDs	OMIM: 601406; MGI: 1924295; HomoloGene: 10869; GeneCards: BCL7A; OMA:BCL7A - orthologs
Gene location (Human)
Chr.	Chromosome 12 (human)
End	122,062,044 bp
Gene location (Mouse)
Chr.	Chromosome 5 (mouse)
End	123,513,055 bp
RNA expression pattern
	Top expressed in
	ganglionic eminence; ; ventricular zone; ; prefrontal cortex; ; superior frontal gyrus; ; Brodmann area 9; ; cerebellum; ; cerebellar cortex; ; cerebellar hemisphere; ; right hemisphere of cerebellum; ; primary visual cortex;
	Top expressed in
	hand; ; ganglionic eminence; ; superior cervical ganglion; ; utricle; ; ventricular zone; ; olfactory system; ; olfactory epithelium; ; prefrontal cortex; ; piriform cortex; ; primary motor cortex;
	More reference expression data
	n/a
Gene ontology
Molecular function	protein binding; molecular function;
Cellular component	cellular component;
Biological process	negative regulation of transcription, DNA-templated;
	Sources:Amigo / QuickGO
Orthologs
	605
	77045
	ENSG00000282873; ENSG00000110987
	ENSMUSG00000029438
	Q4VC05
	Q9CXE2
	NM_020993; NM_001024808
	NM_029850
	NP_001019979; NP_066273
	NP_084126
	Wikidata
View/Edit Human	View/Edit Mouse

B-cell CLL/lymphoma 7 protein family member A is a protein that in humans is encoded by the BCL7A gene. ^[5]

Function

This gene is directly involved, with Myc and IgH, in a three-way gene translocation in a Burkitt lymphoma cell line. As a result of the gene translocation, the N-terminal region of the gene product is disrupted, which is thought to be related to the pathogenesis of a subset of high-grade B cell non-Hodgkin lymphoma. The N-terminal segment involved in the translocation includes the region that shares a strong sequence similarity with those of BCL7B and BCL7C. Two transcript variants encoding different isoforms have been found for this gene.

References

^ ^a ^b ^c ENSG00000110987 GRCh38: Ensembl release 89: ENSG00000282873, ENSG00000110987 – Ensembl, May 2017
^ ^a ^b ^c GRCm38: Ensembl release 89: ENSMUSG00000029438 – Ensembl, May 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "BCL7A BAF chromatin remodeling complex subunit BCL7A [ Homo sapiens (human) ]". Retrieved 2019-04-28.

van Doorn R, Zoutman WH, Dijkman R, de Menezes RX, Commandeur S, Mulder AA, van der Velden PA, Vermeer MH, Willemze R, Yan PS, Huang TH, Tensen CP (2005). "Epigenetic profiling of cutaneous T-cell lymphoma: promoter hypermethylation of multiple tumor suppressor genes including BCL7a, PTPRG, and p73". J. Clin. Oncol. 23 (17): 3886–96. doi:10.1200/JCO.2005.11.353. PMID 15897551.
Carbone A, Bernardini L, Valenzano F, Bottillo I, De Simone C, Capizzi R, Capalbo A, Romano F, Novelli A, Dallapiccola B, Amerio P (2008). "Array-based comparative genomic hybridization in early-stage mycosis fungoides: recurrent deletion of tumor suppressor genes BCL7A, SMAC/DIABLO, and RHOF". Genes Chromosomes Cancer. 47 (12): 1067–75. doi:10.1002/gcc.20601. PMID 18663754. S2CID 205827302.
Morton LM, Purdue MP, Zheng T, Wang SS, Armstrong B, Zhang Y, Menashe I, Chatterjee N, Davis S, Lan Q, Vajdic CM, Severson RK, Holford TR, Kricker A, Cerhan JR, Leaderer B, Grulich A, Yeager M, Cozen W, Hoar Zahm S, Chanock SJ, Rothman N, Hartge P (2009). "Risk of non-Hodgkin lymphoma associated with germline variation in genes that regulate the cell cycle, apoptosis, and lymphocyte development". Cancer Epidemiol. Biomarkers Prev. 18 (4): 1259–70. doi:10.1158/1055-9965.EPI-08-1037. PMC 2716008. PMID 19336552.
Morton LM, Purdue MP, Zheng T, Wang SS, Armstrong B, Zhang Y, Menashe I, Chatterjee N, Davis S, Lan Q, Vajdic CM, Severson RK, Holford TR, Kricker A, Cerhan JR, Leaderer B, Grulich A, Yeager M, Cozen W, Hoar Zahm S, Chanock SJ, Rothman N, Hartge P (2009). "Risk of non-Hodgkin lymphoma associated with germline variation in genes that regulate the cell cycle, apoptosis, and lymphocyte development". Cancer Epidemiol. Biomarkers Prev. 18 (4): 1259–70. doi:10.1158/1055-9965.EPI-08-1037. PMC 2716008. PMID 19336552.
Liang XS, Caporaso N, McMaster ML, Ng D, Landgren O, Yeager M, Chanock S, Goldin LR (2009). "Common genetic variants in candidate genes and risk of familial lymphoid malignancies". Br. J. Haematol. 146 (4): 418–23. doi:10.1111/j.1365-2141.2009.07790.x. PMC 2890251. PMID 19573080.
Hosgood HD, Zhang L, Shen M, Berndt SI, Vermeulen R, Li G, Yin S, Yeager M, Yuenger J, Rothman N, Chanock S, Smith M, Lan Q (2009). "Association between genetic variants in VEGF, ERCC3 and occupational benzene haematotoxicity". Occup Environ Med. 66 (12): 848–53. doi:10.1136/oem.2008.044024. PMC 2928224. PMID 19773279.
Litvinov IV, Zhou Y, Kupper TS, Sasseville D (2013). "Loss of BCL7A expression correlates with poor disease prognosis in patients with early-stage cutaneous T-cell lymphoma". Leuk. Lymphoma. 54 (3): 653–4. doi:10.3109/10428194.2012.717695. PMID 22856870. S2CID 46257094.

This article on a gene on human chromosome 12 is a stub. You can help Wikipedia by expanding it.

This article incorporates text from the United States National Library of Medicine, which is in the public domain.

[refGRCh38Ensembl-1] ENSG00000110987 GRCh38: Ensembl release 89: ENSG00000282873, ENSG00000110987 – Ensembl, May 2017

[refGRCm38Ensembl-2] GRCm38: Ensembl release 89: ENSMUSG00000029438 – Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[entrez-5] "BCL7A BAF chromatin remodeling complex subunit BCL7A [ Homo sapiens (human) ]". Retrieved 2019-04-28.

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BCL7A

Function

See also

References

Further reading