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Betty Diamond

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Betty Diamond
Born11 May 1948
Hartford, CT
NationalityAmerican
EducationRadcliffe College, Harvard Medical School
Occupation(s)Physician, Scientist
EmployerThe Feinstein Institute for Medical Research
Known forMedical Research

Betty Diamond (born 11 May 1948, in Hartford, Connecticut) is an American physician and researcher. She is director of the Institute of Molecular Medicine at Northwell Health's Feinstein Institute for Medical Research in Manhasset, NY.[1] She was elected a member of the National Academy of Sciences in 2022.[2][3]

Education

Betty Diamond received her B.A. in Art History (Magna Cum) from Radcliffe College in 1969 and her M.D. from Harvard Medical School in 1973. In 1976 she began her residency at Columbia Presbyterian Medical Center, New York, NY and in 1979 embarked on post-doctoral fellowship in Immunology with Dr. Matthew Scharff at the Albert Einstein College of Medicine, Bronx, NY.[4][1]

Academic career

Diamond has been on the faculty and chief of rheumatology at both Einstein and Columbia. She is currently head of the Center for Autoimmune and Musculoskeletal Disease at The Feinstein Institute for Medical Research and Professor of Molecular Medicine at Hofstra Northwell School of Medicine.[4][1] She has been on the board of the American College of Rheumatology, is past president of the American Association of Immunology, and is a member of the Institute of Medicine.[5] She is also past chair of the scientific advisory board of the National Institute of Arthritis and Musculoskeletal and Skin Diseases (NIAMS) and has been on their Scientific Council.[6][7][8]

Diamond helped to establish (and named) the Advancing Women in Science and Medicine group at the Feinstein Institutes in 2010. AWSM (pronounced “awesome”) uses philanthropic support to help advance the careers of women scientists, countering gender bias and increasing gender equity.[9][4]

Research

Diamond's primary interests are in the mechanisms of central and peripheral tolerance of autoreactive B cells,[10][11] and the defects in these mechanisms that are present in autoimmune disease, as well as the role of antibodies in brain disease.[12][13] Diamond identified the first idiotype marker on anti-DNA antibodies in patients with lupus,[14][15] and discovered that anti-DNA antibodies in patients and mice shared characteristics with antibodies to pneumococcal polysaccharide. Diamond showed that a single base change in a protective anti-pneumococcal antibody could convert it into a potentially pathogenic anti-DNA antibody. She also found that a peptide that binds to 50% of anti-DNA antibodies in lupus patients and mice represents an epitope on glutamate receptors of the brain and can destroy neurons. Antibodies against the epitope are present in the cerebrospinal fluid and in brain tissue of patients with neuropsychiatric lupus.[16][17] Her work provides a mechanism for aspects of neuropsychiatric lupus, and more generally for acquired changes in cognition and behavior.[18][19][20][21] Diamond also studies the role that hormones may play in the development of lupus.[22][23][4]

Selected awards and honors

References

  1. ^ a b c d e "Betty Diamond, MD". Feinstein Institutes for Medical Research. Retrieved 28 April 2023.
  2. ^ a b "National Academy of Sciences Elects Members and International Members". NAS Online. National Academy of Sciences. 3 May 2022. Retrieved 14 July 2022.
  3. ^ a b Zeller, Gregory (10 May 2022). "Feinstein's Diamond, SBU math whiz earn NAS nods - Innovate Long Island". Innovateli. Retrieved 28 April 2023.
  4. ^ a b c d Diamond, Betty (26 April 2023). "Not Dead Yet". Annual Review of Immunology. 41 (1): 1–15. doi:10.1146/annurev-immunol-101721-065214. ISSN 0732-0582. PMID 37126416. S2CID 258368440. Retrieved 28 April 2023.
  5. ^ a b "Betty A. Diamond, M.D." The American Association of Immunologists. Retrieved 28 April 2023.
  6. ^ "Our Team". Autoimmune Association. Retrieved 28 April 2023.
  7. ^ "Betty Diamond, MD | Scientific Advisory Board". Arthritis National Research Foundation | Funding Research To Cure Arthritis. Retrieved 28 April 2023.
  8. ^ "Molecular Medicine An Interview with Betty Diamond". Leaders Online. 2020. Retrieved 28 April 2023.
  9. ^ Allen, Julianne Mosher (3 October 2022). "Betty Diamond receives Women in Medicine and Science Leadership Award | Northwell Health". Northwell Health News. Retrieved 1 May 2023.
  10. ^ Venkatesh, Jeganathan; Peeva, Elena; Xu, Xiaonan; Diamond, Betty (15 March 2006). "Cutting Edge: Hormonal Milieu, Not Antigenic Specificity, Determines the Mature Phenotype of Autoreactive B Cells". The Journal of Immunology. 176 (6): 3311–3314. doi:10.4049/jimmunol.176.6.3311. PMID 16517697. S2CID 1255454. Retrieved 28 April 2023.
  11. ^ Coico, Richard; Sunshine, Geoffrey (14 January 2009). Immunology: A Short Course. John Wiley & Sons. ISBN 978-0-470-08158-7.
  12. ^ Meislin, Margy (11 May 2022). "LRA and LT Congratulate Betty Diamond, MD on Election to the National Academy of Sciences". Lupus Research. Retrieved 28 April 2023.
  13. ^ Kowal, Czeslawa; DeGiorgio, Lorraine A.; Lee, Ji Y.; Edgar, Mark A.; Huerta, Patricio T.; Volpe, Bruce T.; Diamond, Betty (26 December 2006). "Human lupus autoantibodies against NMDA receptors mediate cognitive impairment". Proceedings of the National Academy of Sciences. 103 (52): 19854–19859. doi:10.1073/pnas.0608397104. ISSN 0027-8424. PMC 1702320. PMID 17170137.
  14. ^ Halpern, R; Schiffenbauer, J; Solomon, G; Diamond, B (1 October 1984). "Detection of masked anti-DNA antibodies in lupus sera by a monoclonal anti-idiotype". The Journal of Immunology. 133 (4): 1852–1856. doi:10.4049/jimmunol.133.4.1852. ISSN 0022-1767. PMID 6332136. S2CID 25611127. Retrieved 28 April 2023.
  15. ^ Kohler, Heinz (2000). "Superantibodies" (PDF). Applied Biochemistry and Biotechnology. 83 (1–3): 1–12. doi:10.1385/ABAB:83:1-3:1. PMID 10826945.
  16. ^ Kivity, Shaye; Katzav, Aviva; Arango, Maria Teresa; Landau-Rabi, Moran; Zafrir, Yaron; Agmon-Levin, Nancy; Blank, Miri; Anaya, Juan-Manuel; Mozes, Edna; Chapman, Joab; Shoenfeld, Yehuda (4 April 2013). "16/6-idiotype expressing antibodies induce brain inflammation and cognitive impairment in mice: the mosaic of central nervous system involvement in lupus". BMC Medicine. 11 (1): 90. doi:10.1186/1741-7015-11-90. ISSN 1741-7015. PMC 3616817. PMID 23556432.{{cite journal}}: CS1 maint: unflagged free DOI (link)
  17. ^ Bosch, Xavier; Ramos-Casals, Manuel; Khamashta, Munther A. (April 2012). "The DWEYS peptide in systemic lupus erythematosus". Trends in Molecular Medicine. 18 (4): 215–223. doi:10.1016/j.molmed.2012.01.008. ISSN 1471-4914. PMID 22365619.
  18. ^ Stock, AD; Wen, J; Putterman, C (25 December 2013). "Neuropsychiatric Lupus, the Blood Brain Barrier, and the TWEAK/Fn14 Pathway". Frontiers in Immunology. 4: 484. doi:10.3389/fimmu.2013.00484. ISSN 1664-3224. PMC 3872310. PMID 24400009.
  19. ^ Jancin, Bruce (13 April 2019). "ACE inhibitors may improve neuropsychiatric lupus". MDedge Rheumatology. Retrieved 28 April 2023.
  20. ^ Kivity, Shaye; Agmon-Levin, Nancy; Zandman-Goddard, Gisele; Chapman, Joab; Shoenfeld, Yehuda (4 March 2015). "Neuropsychiatric lupus: a mosaic of clinical presentations". BMC Medicine. 13 (1): 43. doi:10.1186/s12916-015-0269-8. ISSN 1741-7015. PMC 4349748. PMID 25858312.{{cite journal}}: CS1 maint: unflagged free DOI (link)
  21. ^ Govoni, Marcello; Hanly, John G (5 December 2020). "The management of neuropsychiatric lupus in the 21st century: still so many unmet needs?". Rheumatology. 59 (Supplement_5): v52–v62. doi:10.1093/rheumatology/keaa404. PMC 7719041. PMID 33280014.
  22. ^ Diamond, Betty; Huerta, Patricio T.; Mina-Osorio, Paola; Kowal, Czeslawa; Volpe, Bruce T. (June 2009). "Losing your nerves? Maybe it's the antibodies". Nature Reviews Immunology. 9 (6): 449–456. doi:10.1038/nri2529. ISSN 1474-1741. PMC 2783680. PMID 19424277.
  23. ^ Petri, M (May 2008). "Sex hormones and systemic lupus erythematosus". Lupus. 17 (5): 412–415. doi:10.1177/0961203308090026. ISSN 0961-2033. PMID 18490418. S2CID 7730215.
  24. ^ American College of Rheumatology (11 October 2022). "American College of Rheumatology announces 2022 award recipients". EurekAlert!. Retrieved 28 April 2023.
  25. ^ "Feinstein Institutes' Betty Diamond Elected to the National Academy of Sciences". Businesswire. 4 May 2022. Retrieved 28 April 2023.
  26. ^ Allen, Julianne Mosher (3 October 2022). "Feinstein Institutes' Betty Diamond receives Women in Medicine and Science Leadership Award". Businesswire. Retrieved 28 April 2023.
  27. ^ Quinn, Richard (13 January 2012). "ACR Honors Contributions to Rheumatology - Page 3 of 10". The Rheumatologist. Retrieved 28 April 2023.
  28. ^ "Evelyn V. Hess, MD, MACP, MACR Award". Lupus Foundation of America. Retrieved 28 April 2023.
  29. ^ "AAAS Fellows" (PDF). American Association for the Advancement of Science. Retrieved 28 April 2023.
  30. ^ "About Us: Scientific Advisors". Lupus Research Institute. Archived from the original on 27 July 2011. Retrieved 1 August 2011.
  31. ^ "Alumni Awards". Alumni | Albert Einstein College of Medicine. Retrieved 28 April 2023.
  32. ^ "Past Howley Prize Recipients". The Arthritis Foundation. Retrieved 28 April 2023.
  33. ^ "ACR Past Awards of Distinction Recipients" (PDF). American College of Rheumatology. Retrieved 1 August 2011.
  34. ^ "New Investigators Supported". S.L.E. Lupus Foundation. Archived from the original on 14 August 2011. Retrieved 1 August 2011.
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