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WIF1

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WIF1
Available structures
PDBOrtholog search: PDBe RCSB
Identifiers
AliasesWIF1, WIF-1, WNT inhibitory factor 1
External IDsOMIM: 605186; MGI: 1344332; HomoloGene: 31430; GeneCards: WIF1; OMA:WIF1 - orthologs
Orthologs
SpeciesHumanMouse
Entrez
Ensembl
UniProt
RefSeq (mRNA)

NM_007191

NM_011915

RefSeq (protein)

NP_009122

NP_036045

Location (UCSC)Chr 12: 65.05 – 65.12 MbChr 10: 120.87 – 120.94 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

Wnt inhibitory factor 1 is a protein that in humans is encoded by the WIF1 gene.[5] WIF1 is a lipid-binding protein that binds to Wnt proteins and prevents them from triggering signalling.[6][7][8]

Function

WNT proteins are extracellular signaling molecules involved in the control of embryonic development. This gene encodes a secreted protein, which binds WNT proteins and inhibits their activities. This protein contains a WNT inhibitory factor (WIF) domain and 5 epidermal growth factor (EGF)-like domains. It may be involved in mesoderm segmentation. This protein is found to be present in fish, amphibia and mammals.[5]

References

  1. ^ a b c GRCh38: Ensembl release 89: ENSG00000156076Ensembl, May 2017
  2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000020218Ensembl, May 2017
  3. ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. ^ a b "Entrez Gene: WIF1 WNT inhibitory factor 1".
  6. ^ Malinauskas T, Aricescu AR, Lu W, Siebold C, Jones EY (July 2011). "Modular mechanism of Wnt signaling inhibition by Wnt inhibitory factor 1". Nature Structural & Molecular Biology. 18 (8): 886–893. doi:10.1038/nsmb.2081. PMC 3430870. PMID 21743455.
  7. ^ Malinauskas T (2008). "Docking of fatty acids into the WIF domain of the human Wnt inhibitory factor-1". Lipids. 43 (3): 227–30. doi:10.1007/s11745-007-3144-3. PMID 18256869. S2CID 31357937.
  8. ^ Hsieh JC, Kodjabachian L, Rebbert ML, Rattner A, Smallwood PM, Samos CH, Nusse R, Dawid IB, Nathans J (Apr 1999). "A new secreted protein that binds to Wnt proteins and inhibits their activities". Nature. 398 (6726): 431–6. Bibcode:1999Natur.398..431H. doi:10.1038/18899. PMID 10201374. S2CID 4376660.

Further reading