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John Constantino

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John Constantino
Occupation(s)Blanche F. Ittleson Professor of Psychiatry and Pediatrics
AwardsGeorge Tarjan Award, American Academy of Child and Adolescent Psychiatry, 2015
Academic background
Alma materCornell University; Washington University School of Medicine
Academic work
InstitutionsWashington University School of Medicine

John N. Constantino is a child psychiatrist and expert on neurodevelopmental disorders, especially autism spectrum disorders (ASD).[1] Constantino is the Blanche F. Ittleson Professor of Psychiatry and Pediatrics at Washington University School of Medicine.[2]

Constantino is best known for developing the Social Responsiveness Scale (SRS),[3] a diagnostic rating scale used to distinguish autism spectrum disorder from other child psychiatric conditions by identifying the presence and extent of social impairments.[4] The SRS, published in 2005, consists of a parent and teacher rating scale. It has been used to assess personality, language, and social-behavioral characteristics indicative of the broader autism phenotype.[5] The SRS is a widely used tool to help clinicians identify social impairments in individuals both with and without a diagnosis of ASD.

Constantino received the 2015 George Tarjan Award from the American Academy of Child and Adolescent Psychiatry.[6] In 2013, he received the Alumni Achievement Award from the Washington University School of Medicine.[7]

Biography

Constantino earned his B.A. at Cornell University in 1984. Constantino completed his medical degree at Washington University School of Medicine in 1988. After completed a 5-year a combined residency in pediatrics, general psychiatry and child psychiatry at the Albert Einstein School of Medicine, Constantino joined the faculty of Washington University School of Medicine where he has remained throughout his career. He is co-director of Washington University's Intellectual and Developmental Disabilities Research Center (IDDRC). His research program at the IDDRC has been funded through numerous grants from the National Institutes of Health.[8]

Research

Constantino's research program focuses on developmental disabilities and social development from infancy through early adulthood.[9] Some of his most influential work has used twin studies to examine the prevalence of autistic traits in the general population (also referred to as the broader autism phenotype[10]) and in at-risk groups including individuals with attention deficit hyperactivity disorder who have heightened rates of autistic traits.[11]

As a member of the Autism Genome Project Consortium,[12] Constantino has been involved in genetic linkage studies of autism risk.[13] Other research has examined patterns of familial aggregation in multiplex autism, defined as instances where two or more individuals in the same family are affected.[14] In recent work, Constantino and his colleagues have studied developmental outcomes of over 1600 toddlers with ASD who varied in whether they were identified through prospective studies, community referral, or universal screening.[15] Toddlers who were part of prospective studies of infants at high familial risk for ASD (typically due to having an older sibling with an ASD diagnosis) had better outcomes, including higher developmental levels and lower symptom severity.

Representative publications

  • Constantino, J. N., Davis, S. A., Todd, R. D., Schindler, M. K., Gross, M. M., Brophy, S. L., ... & Reich, W. (2003). Validation of a brief quantitative measure of autistic traits: comparison of the social responsiveness scale with the autism diagnostic interview-revised. Journal of Autism and Developmental Disorders, 33(4), 427–433.
  • Constantino, J. N., Gruber, C. P., Davis, S., Hayes, S., Passanante, N., & Przybeck, T. (2004). The factor structure of autistic traits. Journal of Child Psychology and Psychiatry, 45(4), 719–726.
  • Constantino, J. N., & Todd, R. D. (2003). Autistic traits in the general population: a twin study. Archives of General Psychiatry, 60(5), 524–530.
  • Constantino, J. N., & Todd, R. D. (2005). Intergenerational transmission of subthreshold autistic traits in the general population. Biological Psychiatry, 57(6), 655–660.
  • Constantino, J. N., Zhang, Y. I., Frazier, T., Abbacchi, A. M., & Law, P. (2010). Sibling recurrence and the genetic epidemiology of autism. American Journal of Psychiatry, 167(11), 1349–1356.

References

  1. ^ Hughes, Virginia (2008-11-03). "John Constantino: Educating communities about autism's complexities". Spectrum: Autism Research News. Retrieved 2019-05-02.
  2. ^ "Faculty Details | Psychiatry | Washington University". www.psychiatry.wustl.edu. Retrieved 2019-05-07.
  3. ^ Constantino, John N. (2002). The social responsiveness scale. Los Angeles, CA: Western Psychological Services.
  4. ^ "(SRS™) Social Responsiveness Scale™ | WPS". www.wpspublish.com. Retrieved 2019-03-26.
  5. ^ Constantino, John N.; Davis, Sandra A.; Todd, Richard D.; Schindler, Matthew K.; Gross, Maggie M.; Brophy, Susan L.; Metzger, Lisa M.; Shoushtari, Christiana S.; Splinter, Reagan (2003-08-01). "Validation of a Brief Quantitative Measure of Autistic Traits: Comparison of the Social Responsiveness Scale with the Autism Diagnostic Interview-Revised". Journal of Autism and Developmental Disorders. 33 (4): 427–433. doi:10.1023/A:1025014929212. ISSN 1573-3432. PMID 12959421. S2CID 12491364.
  6. ^ "Constantino, Luby receive awards from child psychiatry academy | The Source | Washington University in St. Louis". The Source. 2015-10-30. Retrieved 2019-05-07.
  7. ^ "John N. Constantino, MD". Washington University School of Medicine in St. Louis. Retrieved 2019-05-07.
  8. ^ "$6.5 million to fund research, treatment of developmental disabilities". Washington University School of Medicine in St. Louis. 2015-11-23. Retrieved 2019-05-07.
  9. ^ "Research Summaries | Psychiatry | Washington University". www.psychiatry.wustl.edu. Retrieved 2019-04-30.
  10. ^ Constantino, John N.; Todd, Richard D. (2003-05-01). "Autistic Traits in the General Population: A Twin Study". Archives of General Psychiatry. 60 (5): 524–30. doi:10.1001/archpsyc.60.5.524. ISSN 0003-990X. PMID 12742874.
  11. ^ Reiersen, Angela M.; Constantino, John N.; Volk, Heather E.; Todd, Richard D. (2007). "Autistic traits in a population-based ADHD twin sample". Journal of Child Psychology and Psychiatry. 48 (5): 464–472. doi:10.1111/j.1469-7610.2006.01720.x. ISSN 1469-7610. PMID 17501727.
  12. ^ "dbGaP | phs000267.v1.p1 | Autism Genome Project (AGP) Consortium - Whole Genome Association and Copy Number Variation Study of over 1,500 Parent-Offspring Trios - Stage I". www.ncbi.nlm.nih.gov. Retrieved 2019-05-13.
  13. ^ Autism Genome Project Consortium (2007). "Mapping autism risk loci using genetic linkage and chromosomal rearrangements". Nature Genetics. 39 (3): 319–328. doi:10.1038/ng1985. ISSN 1061-4036. PMC 4867008. PMID 17322880.
  14. ^ Virkud, Yamini V.; Todd, Richard D.; Abbacchi, Anna M.; Zhang, Yi; Constantino, John N. (2009). "Familial aggregation of quantitative autistic traits in multiplex versus simplex autism". American Journal of Medical Genetics Part B: Neuropsychiatric Genetics. 150B (3): 328–334. doi:10.1002/ajmg.b.30810. ISSN 1552-485X. PMC 2819431. PMID 18618672.
  15. ^ Micheletti, Megan; McCracken, Courtney; Constantino, John N.; Mandell, David; Jones, Warren; Klin, Ami (2019-04-29). "Research Review: Outcomes of 24‐ to 36‐month‐old children with autism spectrum disorder vary by ascertainment strategy: a systematic review and meta‐analysis". Journal of Child Psychology and Psychiatry. 61 (1): 4–17. doi:10.1111/jcpp.13057. ISSN 0021-9630. PMC 6819204. PMID 31032937.
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