Bocasan
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Bocasan was an oral wound cleanser manufactured in the United Kingdom by Knox Laboratories Ltd of London from 1960–1975,[1] before being rebranded as an Oral-B product [2]
Production of Bocasan appears to have ceased by 2003. A similar product, Amosan was available for a period before also ceasing production in 2010. As of 2013, a Dutch pharmacy offers the same formulation under the name Bikosan[3]
It was used to aid treatment, in adults or children over 5 years old, of periodontal conditions such as canker sores, denture irritation, orthodontic irritation, or after dental procedures.
Bocasan was packaged in a 1.7 gram envelope, and contained 69.72% sodium perborate monohydrate and 29.68% sodium hydrogen tartrate anhydrous. To use, the contents were dissolved in 30 cubic centimetres of warm water. Half the amount was swilled around the mouth for two minutes and discarded, and the procedure repeated with the remainder. Treatment was recommended three times a day after meals.
A 1979 double-blind crossover study[4] suggests that hydrogen peroxide, which is released during the use of this product, may prevent or retard colonization and multiplication of anaerobic bacteria, such as those that inhabit oral wounds. A small (n=12) 1998 RCT shows that Bocasan combined with chlorhexidine mouthwash is better than chlorhexidine alone in preventing plaque.[5] A further study (n=28) shows that Bocasan reduces the staining associated with chlorhexidine.[6]
Drug facts
- Active ingredient: Sodium perborate monohydrate
- Inactive ingredients: Sodium hydrogen tartrate
- Purpose: Oral cleanser
- Normal use: Use up to three times daily, after meals or as directed by a dentist
References
- ^ "Two sachets of Bocasan mouthwash powder, supplied by Knox la < CultureGrid".
- ^ Medicines: The Comprehensive Guide edited by Dr. Ian Morton, Judith M. Hall. Royal Society of Medicine. Bloomsbury Publishing, London, 2002. Pg 118
- ^ "Home ⋆ Bik & Bik Online Pharmacy".
- ^ Wennstrom, Jan; Lindhe, Jan (April 1979). "Effect of hydrogen peroxide on developing plaque and gingivitis in man". Journal of Clinical Periodontology. 6 (2): 115–30. doi:10.1111/j.1600-051x.1979.tb02190.x. PMID 379049.
- ^ Dona, BL; Gründemann, LJ; Steinfort, J; Timmerman, MF; van der Weijden, GA (November 1998). "The inhibitory effect of combining chlorhexidine and hydrogen peroxide on 3-day plaque accumulation". Journal of Clinical Periodontology. 25 (11 Pt 1): 879–83. doi:10.1111/j.1600-051x.1998.tb02385.x. PMID 9846796.
- ^ Gründemann, LJ; Timmerman, MF; Ijzerman, Y; van der Weijden, GA; van der Weijden, GA (January 2000). "Stain, plaque and gingivitis reduction by combining chlorhexidine and peroxyborate". Journal of Clinical Periodontology. 27 (1): 9–15. doi:10.1034/j.1600-051x.2000.027001009.x. PMID 10674956.