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David A. Evans

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David A. Evans
David A. Evans picture from Nature journal
Born
David Albert Evans

(1941-01-11)January 11, 1941
Washington, D.C., U.S.
DiedApril 29, 2022(2022-04-29) (aged 81)
NationalityUSA
Alma materOberlin College B.S. (1963)

University of Michigan

California Institute of Technology Ph.D. (1967)
Scientific career
FieldsSynthetic organic chemistry
InstitutionsUniversity of California, Los Angeles (1967-1974)

California Institute of Technology (1974-1983)

Harvard University (1983-2022)
ThesisA Stereoselective Approach Toward the Synthesis of Some Pentacyclic Triterpenes (1968)
Doctoral advisorRobert E. Ireland
Other academic advisorsNorman Craig
Doctoral studentsErick M. Carreira, Gregory Fu, Margaret Faul, James L. Leighton, Yimon Aye
Other notable studentsTehshik Yoon, Amir H. Hoveyda, Mark Lautens, David MacMillan, Marisa Kozlowski
Websiteevans.rc.fas.harvard.edu

David A. Evans (January 11, 1941 – April 29, 2022)[1][2][3] was an American chemist who was the Abbott and James Lawrence professor of chemistry at Harvard University.[4][5] He was a prominent figure in the field of organic chemistry and his research focused on synthetic chemistry and total synthesis, particularly of large biologically active molecules. Among his best-known works is the development of aldol reaction methodology (for example, Evans' acyl oxazolidinone method).[6]

Early life and education

Evans was born on January 11, 1941, in Washington, D.C. He received his A.B. from Oberlin College in 1963, where he worked with Norman Craig.[7] He began his graduate work at the University of Michigan with Robert E. Ireland, but moved with the Ireland group to the California Institute of Technology and received his Ph.D. from Caltech in 1967.[4][5][7]

Academic career

Evans began his independent research career at the University of California, Los Angeles, where he joined the faculty in 1967 and became a full professor in 1973. He then moved to the California Institute of Technology and remained there until 1983, when he moved again to Harvard University.[7] He was appointed the Abbott and James Lawrence Professor of Chemistry in 1990, served as chair of the Department of Chemistry and Chemical Biology from 1995 to 1998, and retired from the faculty, assuming professor emeritus status, in 2008.[4][5]

Research

Evans made many scholarly contributions to the field of organic chemistry.[7] Although he is best known for his work on the aldol reaction, he also developed methodology for anionic oxy-Cope rearrangements, metal catalyzed hydroborations, and catalytic, enantioselective reactions based on bis-oxazoline (box) ligands. The Evans–Saksena reduction[8][9] and Evans–Tishchenko reaction take their names from him.[10] He is also well known for preparing a set of unpublished though widely disseminated lecture notes for Chemistry 206, a graduate-level organic chemistry course at Harvard.[11]

Developing ChemDraw

The widely used chemical structure drawing software package ChemDraw was initially conceived by Evans and was developed by a graduate student, Stewart Rubenstein, with input from Evans, his wife Sally, and the Evans research group for the preparation of the group's manuscripts.[12] ChemDraw was premiered in July 1985 at the Gordon Research Conference on Reactions & Processes in New Hampshire where Rubenstein and the Evanses demonstrated the new software during a break in the conference.[13]

Awards and honors

References

  1. ^ David A. Evans (1941-2022)
  2. ^ Lautens, Mark (June 23, 2022). "David A. Evans (1941–2022)". Nature. 606 (7916): 859. doi:10.1038/d41586-022-01737-5. PMID 35739264. S2CID 249989990.
  3. ^ HALFORD, BETHANY (May 5, 2022). "Organic chemist David A. Evans dies at 81". Chemical & Engineering News. 100 (16).
  4. ^ a b c d e f g h i "David A. Evans - Curriculum Vitae". Harvard University. Retrieved March 14, 2017.
  5. ^ a b c "David Evans". Harvard University. Retrieved March 14, 2017.
  6. ^ "Diastereoselective Aldol Condensation Using a Chiral Oxazolidinone Auxiliary: (2S,3S)-3-Hydroxy-3-Phenyl-2-Methylpropanoic Acid". Organic Syntheses. 68: 83. 1990. doi:10.15227/orgsyn.068.0083.
  7. ^ a b c d Evans, David A. (1999). "A view from the far side. Memorable characters and interesting places". Tetrahedron. 55 (29): 8589–8608. doi:10.1016/s0040-4020(99)00436-6.
  8. ^ Saksena, Anil; Mangiaracina, Pietro (1983). "Recent studies on veratrum alkaloids: a new reaction of sodium triacetoxyborohydride [NaBH(OAc)3]". Tetrahedron Letters. 24 (3): 273–276. doi:10.1016/S0040-4039(00)81383-0.
  9. ^ Evans, David; Chapman, K.; Carreira, E. (1988). "Directed reduction of β-hydroxy ketones employing tetramethylammonium triacetoxyborohydride". Journal of the American Chemical Society. 110 (11): 3560–3578. doi:10.1021/ja00219a035.
  10. ^ Evans, David; Hoveyda, Amir (1990). "Samarium-catalyzed intramolecular Tishchenko reduction of β-hydroxy ketones. A stereoselective approach to the synthesis of differentiated anti 1,3-diol monoesters". J. Am. Chem. Soc. 112 (17): 6447–6449. doi:10.1021/ja00173a071.
  11. ^ Evans, David A. (2006). "Harvard's Advanced Organic Chemistry". Internet Archive. Retrieved October 11, 2020.
  12. ^ Evans, David A. (October 13, 2014). "History of the Harvard ChemDraw Project". Angewandte Chemie International Edition. 53 (42): 11140–11145. doi:10.1002/anie.201405820. PMID 25131311.
  13. ^ BETHANY HALFORD (August 18, 2014). "Reflections On ChemDraw". Chemical & Engineering News Archive. 92 (33): 26–27. doi:10.1021/cen-09233-scitech1. ISSN 0009-2347.
  14. ^ "David Evans". National Academy of Sciences Member Directory. Retrieved March 14, 2017.
  15. ^ "Tetrahedron Prize for Creativity in Organic Chemistry or Bioorganic & Medicinal Chemistry". Elsevier. Archived from the original on September 9, 2014. Retrieved January 28, 2015.
  16. ^ "Arthur C. Cope Award". ACS. Retrieved January 19, 2015.
  17. ^ "Past Recipients". American Chemical Society. Retrieved April 11, 2023.
  18. ^ "Roger Adams Award in Organic Chemistry". ACS. Retrieved November 6, 2017.
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