Plithotaxis

Plithotaxis, from the Greek, πλήΘος, denoting crowd, swarm, or throng. In collective cellular migration, plithotaxis is the tendency for each individual cell within a monolayer to migrate along the local orientation of the maximal principal stress, or equivalently, minimal intercellular shear stress.^[1]^[2]^[3] Plithotaxis requires force transmission across many cell-cell junctions and therefore is an emergent property of the cell group.

References

^ Tambe, D.T., Hardin, C., Angelini, T.E., Rajendran, K., Park, C.Y., Serra-Picamal, X., Zhou, E.H., Zaman, M.H., Butler, J.P., Weitz, D.A., Fredberg JJ, Trepat, X, Collective cell guidance by cooperative intercellular forces. Nature Materials,10(6), 469-475, 2011, doi:10.1038/nmat3025.
^ Gov, N. Cell mechanics: Moving under peer pressure. Nature Materials, 10(6), 412-414, 2011, doi:10.1038/nmat3036.
^ Trepat, X, Fredberg, JJ. Plithotaxis and emergent dynamics in collective cellular migration. Trends in Cell Biology - 23 July 2011, doi:10.1016/j.tcb.2011.06.006.

[1] Tambe, D.T., Hardin, C., Angelini, T.E., Rajendran, K., Park, C.Y., Serra-Picamal, X., Zhou, E.H., Zaman, M.H., Butler, J.P., Weitz, D.A., Fredberg JJ, Trepat, X, Collective cell guidance by cooperative intercellular forces. Nature Materials,10(6), 469-475, 2011, doi:10.1038/nmat3025.

[2] Gov, N. Cell mechanics: Moving under peer pressure. Nature Materials, 10(6), 412-414, 2011, doi:10.1038/nmat3036.

[3] Trepat, X, Fredberg, JJ. Plithotaxis and emergent dynamics in collective cellular migration. Trends in Cell Biology - 23 July 2011, doi:10.1016/j.tcb.2011.06.006.

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See also

References