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Chorionic gonadotropin beta

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CGB3
Available structures
PDBHuman UniProt search: PDBe RCSB
Identifiers
AliasesCGB3, CGB5, CGB7, CGB8, hCGB, CGB, Chorionic gonadotropin beta, chorionic gonadotropin beta subunit 3, Choriogonadotropin subunit beta, chorionic gonadotropin subunit beta 3, LHB, β-hCG
External IDsHomoloGene: 37338; GeneCards: CGB3; OMA:CGB3 - orthologs
Orthologs
SpeciesHumanMouse
Entrez
Ensembl
UniProt
RefSeq (mRNA)

NM_000737

n/a

RefSeq (protein)

n/a

Location (UCSC)Chr 19: 49.02 – 49.02 Mbn/a
PubMed search[2]n/a
Wikidata
View/Edit Human

Choriogonadotropin subunit beta (CG-beta) also known as chorionic gonadotrophin chain beta is a protein that in humans is encoded by the CGB gene.[3][4][5]

This gene is a member of the glycoprotein hormone beta chain family and encodes the beta 3 subunit of chorionic gonadotropin (CG). Glycoprotein hormones are heterodimers consisting of a common alpha subunit and a unique beta subunit which confers biological specificity. CG is produced by the trophoblastic cells of the placenta and stimulates the ovaries to synthesize the steroids that are essential for the maintenance of pregnancy. The beta subunit of CG is encoded by 6 genes which are arranged in tandem and inverted pairs on chromosome 19q13.3 and contiguous with the luteinizing hormone beta subunit gene.[3]

References

  1. ^ a b c GRCh38: Ensembl release 89: ENSG00000104827Ensembl, May 2017
  2. ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  3. ^ a b "Entrez Gene: chorionic gonadotropin".
  4. ^ Fiddes JC, Goodman HM (August 1980). "The cDNA for the beta-subunit of human chorionic gonadotropin suggests evolution of a gene by readthrough into the 3'-untranslated region". Nature. 286 (5774): 684–7. doi:10.1038/286684a0. PMID 6774259.
  5. ^ Policastro P, Ovitt CE, Hoshina M, Fukuoka H, Boothby MR, Boime I (October 1983). "The beta subunit of human chorionic gonadotropin is encoded by multiple genes". J. Biol. Chem. 258 (19): 11492–9. PMID 6194155.

This article incorporates text from the United States National Library of Medicine, which is in the public domain.