CACTIN

CACTIN
Identifiers
Aliases	CACTIN, C19orf29, NY-REN-24, fSAPc, cactin, spliceosome C complex subunit
External IDs	OMIM: 618536; MGI: 1917562; HomoloGene: 69553; GeneCards: CACTIN; OMA:CACTIN - orthologs
Gene location (Human)
Chr.	Chromosome 19 (human)
End	3,626,815 bp
Gene location (Mouse)
Chr.	Chromosome 10 (mouse)
End	81,162,076 bp
RNA expression pattern
	Top expressed in
	sural nerve; ; granulocyte; ; right ovary; ; left ovary; ; right hemisphere of cerebellum; ; left uterine tube; ; apex of heart; ; body of uterus; ; gastrocnemius muscle; ; mucosa of transverse colon;
	Top expressed in
	otic vesicle; ; interventricular septum; ; hand; ; abdominal wall; ; primitive streak; ; epiblast; ; gastrula; ; primary oocyte; ; mesenteric lymph nodes; ; thymus;
	More reference expression data
	n/a
Gene ontology
Molecular function	protein binding; RNA binding;
Cellular component	catalytic step 2 spliceosome; nucleoplasm; spliceosomal complex; extracellular exosome; nucleus; cytosol; nuclear speck; cytoplasm;
Biological process	negative regulation of protein phosphorylation; mRNA splicing, via spliceosome; immune system process; negative regulation of type I interferon-mediated signaling pathway; cellular response to tumor necrosis factor; mRNA processing; negative regulation of interferon-beta production; negative regulation of lipopolysaccharide-mediated signaling pathway; multicellular organism development; negative regulation of interleukin-8 production; negative regulation of toll-like receptor signaling pathway; cellular response to interleukin-1; RNA splicing; negative regulation of tumor necrosis factor production; innate immune response; cellular response to lipopolysaccharide; negative regulation of NF-kappaB transcription factor activity;
	Sources:Amigo / QuickGO
Orthologs
	58509
	70312
	ENSG00000105298
	ENSMUSG00000034889
	Q8WUQ7
	Q9CS00
	NM_001080543; NM_021231
	NM_027381
	NP_001074012; NP_067054
	NP_081657
	Wikidata
View/Edit Human	View/Edit Mouse

Cactin also known as renal carcinoma antigen NY-REN-24 is a protein that in humans is encoded by the CACTIN gene.^[5]^[6]^[7]

References

^ ^a ^b ^c GRCh38: Ensembl release 89: ENSG00000105298 – Ensembl, May 2017
^ ^a ^b ^c GRCm38: Ensembl release 89: ENSMUSG00000034889 – Ensembl, May 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ Andersson B, Wentland MA, Ricafrente JY, Liu W, Gibbs RA (Jun 1996). "A "double adaptor" method for improved shotgun library construction". Anal Biochem. 236 (1): 107–13. doi:10.1006/abio.1996.0138. PMID 8619474.
^ Yu W, Andersson B, Worley KC, Muzny DM, Ding Y, Liu W, Ricafrente JY, Wentland MA, Lennon G, Gibbs RA (Jun 1997). "Large-scale concatenation cDNA sequencing". Genome Res. 7 (4): 353–8. doi:10.1101/gr.7.4.353. PMC 139146. PMID 9110174.
^ "Entrez Gene: C19orf29 chromosome 19 open reading frame 29".

Scanlan MJ, Gordan JD, Williamson B, et al. (1999). "Antigens recognized by autologous antibody in patients with renal-cell carcinoma". Int. J. Cancer. 83 (4): 456–64. doi:10.1002/(SICI)1097-0215(19991112)83:4<456::AID-IJC4>3.0.CO;2-5. PMID 10508479.
Jurica MS, Licklider LJ, Gygi SR, et al. (2002). "Purification and characterization of native spliceosomes suitable for three-dimensional structural analysis". RNA. 8 (4): 426–39. doi:10.1017/S1355838202021088. PMC 1370266. PMID 11991638.
Lehner B, Semple JI, Brown SE, et al. (2004). "Analysis of a high-throughput yeast two-hybrid system and its use to predict the function of intracellular proteins encoded within the human MHC class III region". Genomics. 83 (1): 153–67. doi:10.1016/S0888-7543(03)00235-0. PMID 14667819.
Brandenberger R, Wei H, Zhang S, et al. (2005). "Transcriptome characterization elucidates signaling networks that control human ES cell growth and differentiation". Nat. Biotechnol. 22 (6): 707–16. doi:10.1038/nbt971. PMID 15146197.
Sogayar MC, Camargo AA, Bettoni F, et al. (2004). "A transcript finishing initiative for closing gaps in the human transcriptome". Genome Res. 14 (7): 1413–23. doi:10.1101/gr.2111304. PMC 442158. PMID 15197164.
Beausoleil SA, Jedrychowski M, Schwartz D, et al. (2004). "Large-scale characterization of HeLa cell nuclear phosphoproteins". Proc. Natl. Acad. Sci. U.S.A. 101 (33): 12130–5. doi:10.1073/pnas.0404720101. PMC 514446. PMID 15302935.
Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.

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[refGRCh38Ensembl-1] GRCh38: Ensembl release 89: ENSG00000105298 – Ensembl, May 2017

[refGRCm38Ensembl-2] GRCm38: Ensembl release 89: ENSMUSG00000034889 – Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[pmid8619474-5] Andersson B, Wentland MA, Ricafrente JY, Liu W, Gibbs RA (Jun 1996). "A "double adaptor" method for improved shotgun library construction". Anal Biochem. 236 (1): 107–13. doi:10.1006/abio.1996.0138. PMID 8619474.

[pmid9110174-6] Yu W, Andersson B, Worley KC, Muzny DM, Ding Y, Liu W, Ricafrente JY, Wentland MA, Lennon G, Gibbs RA (Jun 1997). "Large-scale concatenation cDNA sequencing". Genome Res. 7 (4): 353–8. doi:10.1101/gr.7.4.353. PMC 139146. PMID 9110174.

[entrez-7] "Entrez Gene: C19orf29 chromosome 19 open reading frame 29".

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References

Further reading