The 1946 Giro di Lombardia, 40th edition of the race, was held on October 27, 1946, on a total route of 231 km. It was won for the first time, of the 4 consecutive, by Italian Fausto Coppi, reached the finish line with the time of 6h24 ' 30 "at an average of 36.047 km/h, preceding the compatriots Luigi Casola and Michele Motta.
129 cyclists took off from Milan and 53 of them completed the race.