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Biological indicator evaluation resistometer

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A Biological Indicator Evaluation Resistometer (BIER) vessel is a piece of equipment used to determine the time taken to reduce survival of a given organism by 90% (also known as a log 1 reduction). The name derives from how the equipment is used.

A BIER vessel evaluates the resistance of biological indicators to moist heat (steam) sterilization.[1] For example, if a 90% reduction is determined to be 5 minutes for the microorganism being evaluated, then a D-value of 5 is assigned. D values are specific to starting bioload, substrate (the material the spores are on), and microbe species.

BIER vessels typically cost in excess of $100,000, and thus tend to be located where biological indicators are manufactured.

References

  1. ^ James P. Agalloco (August 2007). "Innovation in Biological Indicator Evaluator Resistometer Vessel Technology". PharmTech.com. Retrieved 6 June 2019.
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