Martinotti cell
| Martinotti Cell | |
|---|---|
| Identifiers | |
| NeuroLex ID | nifext_55 |
| Anatomical terms of neuroanatomy | |
Martinotti cells are small multipolar neurons with short branching dendrites. They are scattered throughout various layers of the cerebral cortex, sending their axons up to the cortical layer I where they form axonal arborization. The arbors transgress multiple columns in layer VI and make contacts with the distal tuft dendrites of pyramidal cells. [1] Martinotti cells express somatostatin and sometimes calbindin, but not parvalbumin or vasoactive intestinal peptide.[2] Furthermore, Martinotti cells in layer V have been shown to express the nicotinic acetylcholine receptor α2 subunit (Chrna2).[3]
Recent research suggests that Martinotti cells are associated with a cortical dampening mechanism. When the pyramidal neuron, which is the most common type of neuron in the cortex, starts getting overexcited, Martinotti cells start sending inhibitory signals to the surrounding neurons. [4]
Historically, the discovery of Martinotti cells has been mistakenly attributed to Giovanni Martinotti 1888, although it is now accepted that they were actually discovered in 1889 by Carlo Martinotti (1859–1908), a student of Camillo Golgi.[5]
External links
News, press releases
- Rare cell prevents rampant brain activity - on the discovery of potential dampening influence of Martinotti cells.
- NIF Search - Martinotti Cell via the Neuroscience Information Framework
References
- ^ Wang Y, Toledo-Rodriguez M, Gupta A, et al. (November 2004). "Anatomical, physiological and molecular properties of Martinotti cells in the somatosensory cortex of the juvenile rat". J. Physiol. 561 (Pt 1): 65–90. doi:10.1113/jphysiol.2004.073353. PMC 1665344. PMID 15331670.
- ^ Sugino K, Hempel CM, Miller MN, et al. (January 2006). "Molecular taxonomy of major neuronal classes in the adult mouse forebrain". Nat. Neurosci. 9 (1): 99–107. doi:10.1038/nn1618. PMID 16369481.
- ^ Hilscher, Markus M.; Leão, Richardson N.; Edwards, Steven J.; Leão, Katarina E.; Kullander, Klas (2017-02-09). "Chrna2-Martinotti Cells Synchronize Layer 5 Type A Pyramidal Cells via Rebound Excitation". PLOS Biology. 15 (2): e2001392. doi:10.1371/journal.pbio.2001392. ISSN 1545-7885. PMC 5300109. PMID 28182735.
{{cite journal}}: CS1 maint: unflagged free DOI (link) - ^ Silberberg G, Markram H (March 2007). "Disynaptic inhibition between neocortical pyramidal cells mediated by Martinotti cells". Neuron. 53 (5): 735–46. doi:10.1016/j.neuron.2007.02.012. PMID 17329212.
- ^ Martinotti C (1889). "Contributo allo studio della corteccia cerebrale, ed all'origine centrale dei nervi". Ann. Freniatr. Sci. Affini. 1: 14–381.
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