ATP6V1E2

ATP6V1E2
Identifiers
Aliases	ATP6V1E2, ATP6E1, ATP6EL2, ATP6V1EL2, VMA4, ATPase H+ transporting V1 subunit E2
External IDs	OMIM: 617385; MGI: 1922165; HomoloGene: 41770; GeneCards: ATP6V1E2; OMA:ATP6V1E2 - orthologs
Gene location (Human)
Chr.	Chromosome 2 (human)
End	46,542,577 bp
Gene location (Mouse)
Chr.	Chromosome 17 (mouse)
End	87,255,325 bp
RNA expression pattern
	Top expressed in
	sperm; ; right testis; ; left testis; ; gonad; ; islet of Langerhans; ; white blood cell; ; monocyte; ; testicle; ; C1 segment; ; muscle of thigh;
	Top expressed in
	seminiferous tubule; ; spermatid; ; submandibular gland; ; spermatocyte; ; gastrula; ; mucosa of small intestine; ; lumbar spinal ganglion; ; medial ganglionic eminence; ; right ventricle; ; lumbar subsegment of spinal cord;
	More reference expression data
	n/a
Gene ontology
Molecular function	P-type proton-exporting transporter activity; protein binding; proton-transporting ATPase activity, rotational mechanism;
Cellular component	cytosol; acrosomal vesicle; proton-transporting two-sector ATPase complex, catalytic domain;
Biological process	insulin receptor signaling pathway; ion transmembrane transport; ion transport; transferrin transport; regulation of macroautophagy; phagosome acidification;
	Sources:Amigo / QuickGO
Orthologs
	90423
	74915
	ENSG00000250565
	ENSMUSG00000053375
	Q96A05
	Q9D593
	NM_080653; NM_001318063; NM_001371281; NM_001371282; NM_001371283
	NM_029121
	NP_001304992; NP_001358210; NP_001358211; NP_001358212
	NP_083397
	Wikidata
View/Edit Human	View/Edit Mouse

V-type proton ATPase subunit E 2 is an enzyme that in humans is encoded by the ATP6V1E2 gene.^[5]^[6]

References

^ ^a ^b ^c GRCh38: Ensembl release 89: ENSG00000250565 – Ensembl, May 2017
^ ^a ^b ^c GRCm38: Ensembl release 89: ENSMUSG00000053375 – Ensembl, May 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ Imai-Senga Y, Sun-Wada GH, Wada Y, Futai M (May 2002). "A human gene, ATP6E1, encoding a testis-specific isoform of H(+)-ATPase subunit E". Gene. 289 (1–2): 7–12. doi:10.1016/S0378-1119(02)00542-5. PMID 12036578.
^ "Entrez Gene: ATP6V1E2 ATPase, H+ transporting, lysosomal 31kDa, V1 subunit E2".

External links

Human ATP6V1E2 genome location and ATP6V1E2 gene details page in the UCSC Genome Browser.

Nishi T, Forgac M (2002). "The vacuolar (H+)-ATPases--nature's most versatile proton pumps". Nat. Rev. Mol. Cell Biol. 3 (2): 94–103. doi:10.1038/nrm729. PMID 11836511.
Kawasaki-Nishi S, Nishi T, Forgac M (2003). "Proton translocation driven by ATP hydrolysis in V-ATPases". FEBS Lett. 545 (1): 76–85. doi:10.1016/S0014-5793(03)00396-X. PMID 12788495.
Morel N (2004). "Neurotransmitter release: the dark side of the vacuolar-H+ATPase". Biol. Cell. 95 (7): 453–7. doi:10.1016/S0248-4900(03)00075-3. PMID 14597263.
Breton S, Wiederhold T, Marshansky V, et al. (2000). "The B1 subunit of the H+ATPase is a PDZ domain-binding protein. Colocalization with NHE-RF in renal B-intercalated cells". J. Biol. Chem. 275 (24): 18219–24. doi:10.1074/jbc.M909857199. PMID 10748165.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
Smith AN, Lovering RC, Futai M, et al. (2003). "Revised nomenclature for mammalian vacuolar-type H+ -ATPase subunit genes". Mol. Cell. 12 (4): 801–3. doi:10.1016/S1097-2765(03)00397-6. PMID 14580332.
Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.
Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
Hillier LW, Graves TA, Fulton RS, et al. (2005). "Generation and annotation of the DNA sequences of human chromosomes 2 and 4". Nature. 434 (7034): 724–31. doi:10.1038/nature03466. PMID 15815621.

This article on a gene on human chromosome 2 is a stub. You can help Wikipedia by expanding it.

[refGRCh38Ensembl-1] GRCh38: Ensembl release 89: ENSG00000250565 – Ensembl, May 2017

[refGRCm38Ensembl-2] GRCm38: Ensembl release 89: ENSMUSG00000053375 – Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[pmid12036578-5] Imai-Senga Y, Sun-Wada GH, Wada Y, Futai M (May 2002). "A human gene, ATP6E1, encoding a testis-specific isoform of H(+)-ATPase subunit E". Gene. 289 (1–2): 7–12. doi:10.1016/S0378-1119(02)00542-5. PMID 12036578.

[entrez-6] "Entrez Gene: ATP6V1E2 ATPase, H+ transporting, lysosomal 31kDa, V1 subunit E2".

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References

External links

Further reading