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NEK3

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NEK3
Identifiers
AliasesNEK3, HSPK36, NIMA related kinase 3
External IDsOMIM: 604044; MGI: 1344371; HomoloGene: 1869; GeneCards: NEK3; OMA:NEK3 - orthologs
Orthologs
SpeciesHumanMouse
Entrez
Ensembl
UniProt
RefSeq (mRNA)

NM_001146099
NM_002498
NM_152720

NM_001162947
NM_011848

RefSeq (protein)

NP_001139571
NP_002489
NP_689933

NP_001156419
NP_035978

Location (UCSC)Chr 13: 52.13 – 52.16 MbChr 8: 22.62 – 22.66 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

Serine/threonine-protein kinase Nek3 is an enzyme that in humans is encoded by the NEK3 gene.[5][6][7]

In Aspergillus nidulans, lack of the serine/threonine kinase NimA (never in mitosis A) results in cell cycle arrest in G2, while overexpression causes the premature onset of mitotic events. The protein encoded by this gene is similar in sequence to the Aspergillus nidulans protein and may therefore play a role in mitotic regulation. However, the encoded protein differs from other NimA family members in that it is not cell cycle regulated and is found primarily in the cytoplasm. Three transcript variants have been found for this gene, but the full-length nature of only two of them has been characterized.[7]

References

  1. ^ a b c GRCh38: Ensembl release 89: ENSG00000136098Ensembl, May 2017
  2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000031478Ensembl, May 2017
  3. ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. ^ Schultz SJ, Nigg EA (Feb 1994). "Identification of 21 novel human protein kinases, including 3 members of a family related to the cell cycle regulator nimA of Aspergillus nidulans". Cell Growth Differ. 4 (10): 821–30. PMID 8274451.
  6. ^ Schultz SJ, Fry AM, Sutterlin C, Ried T, Nigg EA (Oct 1994). "Cell cycle-dependent expression of Nek2, a novel human protein kinase related to the NIMA mitotic regulator of Aspergillus nidulans". Cell Growth Differ. 5 (6): 625–35. PMID 7522034.
  7. ^ a b "Entrez Gene: NEK3 NIMA (never in mitosis gene a)-related kinase 3".

Further reading