SLITRK2

SLITRK2
Identifiers
Aliases	SLITRK2, CXorf2, SLITL1, SLIT and NTRK like family member 2, CXorf1, TMEM257
External IDs	OMIM: 300561; MGI: 2679449; HomoloGene: 13054; GeneCards: SLITRK2; OMA:SLITRK2 - orthologs
Gene location (Human)
Chr.	X chromosome (human)
End	145,829,856 bp
Gene location (Mouse)
Chr.	X chromosome (mouse)
End	65,704,999 bp
RNA expression pattern
	Top expressed in
	ventricular zone; ; internal globus pallidus; ; caudate nucleus; ; nucleus accumbens; ; ganglionic eminence; ; middle temporal gyrus; ; amygdala; ; right frontal lobe; ; putamen; ; C1 segment;
	Top expressed in
	trigeminal ganglion; ; substantia nigra; ; lumbar subsegment of spinal cord; ; Region I of hippocampus proper; ; dentate gyrus; ; dentate gyrus of hippocampal formation granule cell; ; subiculum; ; ventricular zone; ; neural layer of retina; ; primary motor cortex;
	More reference expression data
	; ; ; ;
	More reference expression data
Orthologs
	84631
	245450
	ENSG00000185985
	ENSMUSG00000036790
	Q9H156
	Q810C0
NM_001144003; NM_001144004; NM_001144005; NM_001144006; NM_001144007;
	NM_001144008; NM_001144009; NM_001144010; NM_032539
	NM_001161431; NM_198863
NP_001137475; NP_001137476; NP_001137477; NP_001137478; NP_001137480;
	NP_001137481; NP_001137482; NP_115928
	NP_001154903; NP_942563
	Wikidata
View/Edit Human	View/Edit Mouse

SLIT and NTRK-like protein 2 is a protein that in humans is encoded by the SLITRK2 gene.^[5]^[6]^[7]

Function

Members of the SLITRK family, such as SLITRK2, are integral membrane proteins with 2 N-terminal leucine-rich repeat (LRR) domains similar to those of SLIT proteins (see SLIT1; MIM 603742). Most SLITRKs, including SLITRK2, also have C-terminal regions that share homology with neurotrophin receptors (see NTRK1; MIM 191315). SLITRKs are expressed predominantly in neural tissues and have neurite-modulating activity.^[7]^[6]

References

^ ^a ^b ^c GRCh38: Ensembl release 89: ENSG00000185985 – Ensembl, May 2017
^ ^a ^b ^c GRCm38: Ensembl release 89: ENSMUSG00000036790 – Ensembl, May 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ Nagase T, Nakayama M, Nakajima D, Kikuno R, Ohara O (April 2001). "Prediction of the coding sequences of unidentified human genes. XX. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro". DNA Research. 8 (2): 85–95. doi:10.1093/dnares/8.2.85. PMID 11347906.
^ ^a ^b Aruga J, Yokota N, Mikoshiba K (October 2003). "Human SLITRK family genes: genomic organization and expression profiling in normal brain and brain tumor tissue". Gene. 315: 87–94. doi:10.1016/S0378-1119(03)00715-7. PMID 14557068.
^ ^a ^b "Entrez Gene: SLITRK2 SLIT and NTRK-like family, member 2".

Function

References

Further reading